A5059958915- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- vaccines and immunoinformatics approaches
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Advanced Photocatalysis Techniques
- Luminescence and Fluorescent Materials
- RNA and protein synthesis mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- RNA modifications and cancer
- Proteins in Food Systems
- Renal cell carcinoma treatment
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Kidney Stones and Urolithiasis Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Electronic and Structural Properties of Oxides
- Covalent Organic Framework Applications
- Ureteral procedures and complications
- Electrocatalysts for Energy Conversion
- Fire effects on concrete materials
- Cellular and Composite Structures
Xuzhou Medical College
2020-2025
Nanjing Drum Tower Hospital
2009-2025
Northeast Agricultural University
2022-2024
Nanjing Tech University
2024
China University of Geosciences (Beijing)
2024
Nanjing University
2022-2023
University of South China
2023
Hunan University
2023
State Key Laboratory of Chemobiosensing and Chemometrics
2023
First Affiliated Hospital of Guangdong Pharmaceutical University
2023
The overall response of cisplatin-based chemotherapy in bladder urothelial carcinoma (BUC) remains unsatisfactory due to the complex pathological subtypes, genomic difference, and drug resistance. genes that associated with cisplatin resistance remain unclear. Herein, we aimed identify BUC. EXPERIMENTAL DESIGN: cytotoxicity was evaluated six cancer cell lines compare their responses cisplatin. T24 cells exhibited lowest sensitivity therefore selected explore mechanisms We performed...
Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common of urinary system. In current study, we investigated function mechanisms Neuropilin-1 (NRP1), co-receptor for vascular endothelial growth factor, in BC pathogenesis progression. The expression NRP1 was evaluated using data extracted from GEO HPA databases examined cell lines. effect on proliferation, apoptosis, angiogenesis, migration, invasion cells were validated after knockdown. After identifying...
Abstract The active sound absorption method has better under low waves, but the effect is very poor high waves. In order to solve this problem, a semi-active proposed, which can change problem by adjusting surface impedance of loudspeaker behind material. Firstly, controllable placed sound-absorbing material, and its adjusted make it match air optimally realize effective adjustment performance. A adjust coefficient effectively condition changing incident frequency always keeping at maximum value.
Bladder cancer remains a major challenge in clinical oncology, particularly due to the development of platinum resistance, which severely impacts patient prognosis. Despite numerous attempts create effective prognostic models, their applicability has often been limited. In this study, we utilized robust statistical approach, LASSO-COX regression analysis, develop novel model for bladder based on cisplatin sensitivity-related genes (CSRGs). The was validated using both TCGA-BLCA dataset and...
CO2 possesses extraordinary thermodynamic stability, and its reduction reaction involves multiple electron-transfer processes. Thus, high-density electron occupation on a catalyst surface is an effective driving force for improving the photocatalytic activity. Here, we report fabrication of Fe-doped Bi2O3 catalysts (denoted as FexBi2-xO3) with different Fe contents using solvothermal method. The self-assembled has nanoflower-like morphology, performance to CO improved largely dependent...
Background Non-muscle invasive bladder cancer (NMIBC) is the most prevalent type of cancer, typically associated with a favorable prognosis and risk recurrence during follow-up period. Inflammatory markers have been used to predict in various types. The aim this study was explore prognostic value readily accessible inflammatory markers, platelet-to-lymphocyte ratio (PLR) interleukin-6 (IL-6), NMIBC. Methods comprised retrospective analysis clinical data collected from NMIBC patients...
Melatonin is a hormone naturally produced by the pineal gland in brain. In addition to modulating circadian rhythms, it has pleiotropic biological effects including antioxidant, immunomodulatory, and anti-cancer effects. Herein, we report that melatonin ability decrease growth metastasis of androgen-dependent prostate cancer.To evaluate effect on androgen-sensitive cancer vitro or vivo, cell proliferation, apoptosis, migration invasion were analyzed using...
Clear cell renal carcinoma (ccRCC) is one of the most lethal urological malignancies, but pathogenesis and prognosis ccRCC remain obscure, which need to be better understand.Differentially expressed genes were identified function enrichment analyses performed using three publicly available gene expression profiles downloaded from Gene Expression Omnibus database. The protein-protein interaction competing endogenous RNA (ceRNA) networks visualized by Cytoscape. Multivariate Cox analysis was...
Abstract Background Long interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. As only autonomous and active retrotransposons, L1 may take part in cancer initiation progression some ways. The studies mainly focus on impact insertion into new genome locus. 5´ untranslated region (UTR) also contains antisense promoter (ASP) activity, generating L1-gene chimeric transcripts to a neighbor exon. Some these ASP-associated genes have been reported be overexpressed promote...
The antitumor activity of Momordica anti-human immunodeficiency virus protein 30 kDa (MAP30) has been proved. However, the role MAP30 on tumor metastasis not yet identified. For this purpose, we investigated effect and underlying mechanism in bladder cancer (BC). Here, reported that significantly inhibited cell proliferation clone formation 5637 T24 cells vitro by promoting apoptosis cycle arrest. We also found migration invasion suppressing epithelial/mesenchymal transition (EMT) process....
We conducted a two-center study to investigate the prognostic value of preoperative fibrinogen-albumin ratio (FAR) in patients undergoing radical cystectomy (RC).The clinical and survival data 267 with bladder cancer (BCa) treated RC were collected, which 140 from Xuzhou Central Hospital divided into training set 127 The Second Affiliated Nantong University validation set. X-tile software was used obtain optimal cut-off values for platelet-to-lymphocyte (PLR), neutrophil-to-lymphocyte (NLR)...