In recent years, segmentation details and computing efficiency have become more important in medical image for clinical applications. deep learning, UNet based on a convolutional neural network is one of the most commonly used models. 3+ was designed as modified by adopting architecture full-scale skip connections. However, feature fusion can result excessively redundant computations. This study aimed to reduce parameters while further improving extraction capability. First, eliminate...

The systemic immune-inflammation index (SII = N × P/L) based on neutrophil (N), platelet (P) and lymphocyte (L) counts is used to predict the survival of patients with malignant tumours can fully reflect balance between host inflammatory immune status. This study conducted explore potential prognostic significance SII in breast cancer undergoing neoadjuvant chemotherapy (NACT). A total 262 received NACT were enrolled this study. According receiver operating characteristic curve, optimal...

Systemic inflammation response index (SIRI=N×M/L), based on neutrophil (N), monocyte (M), and lymphocyte (L) counts, is used to predict the survival of patients with malignant tumors can fully evaluate balance between host immune inflammatory condition. The present study aimed potential prognostic significance SIRI in breast cancer undergoing neoadjuvant chemotherapy.A total 262 treated chemotherapy were enrolled this retrospective study. optimal cutoff value by receiver operating...

Abstract Imbalance in copper homeostasis can be lethal. A recent study found that excess induces cell death a way has never been characterized before, which is dependent on mitochondrial stress and referred to as “cuproptosis.” The role of cuproptosis tumors not yet elucidated. In this study, we revealed the complex important roles regulators activity via comprehensive analysis multiomics data from more than 10,000 samples 33 tumor types. We cyclin‐dependent kinase inhibitor 2A most...

MDM4 is one of the MDM protein family and generally recognized as key negative regulator p53. As a cancer-promoting factor, it plays non-negligible role in tumorigenesis development. In this article, we analyzed expression levels pan-cancer through multiple databases. We also investigated correlations between prognostic value, immune features, genetic mutation, tumor-related pathways. found that overexpression often accompanied by adverse clinical poor prognosis, oncogenic mutations,...

To describe the past, present and future burden of pancreatitis in older adults, to explore cross-national inequalities across socio-demographic index (SDI).

Abstract Cucumber ( Cucumis sativus L.) target leaf spot (TLS), which is caused by the fungus Corynespora cassiicola C. ), seriously endangers production of cucumber. In this assay, we performed comprehensive sequencing transcriptome and microRNAs (miRNAs) a resistant cucumber (Jinyou 38) during inoculation using Illumina NextSeq 500 platform. The possible genes related to response were associated with plant hormones, transcription factors, primary metabolism, Ca 2+ signaling pathways,...

The current investigation examines the potential clinical value and prognostic significance of a systemic immune-inflammation index (SII) in patients with breast cancer.A total 477 individuals underwent neoadjuvant chemotherapy, 308 did not at our center between January 1998 December 2016 were selected. An optimized SII threshold was generated using receiver operating characteristic curve (ROC). relationship various factors cancer predicting disease-free survival (DFS) overall (OS)...

Lower grade glioma (LGG) are a heterogeneous tumor that may develop into high-grade malignant seriously shortens patient survival time. The clinical prognostic biomarker of lower-grade is still lacking. aim our study to explore novel biomarkers for LGG contribute distinguish potential malignancy in low-grade glioma, guide adoption more rational and effective treatments.The RNA-seq data was downloaded from UCSC Xena the Chinese Glioma Genome Atlas (CGGA). By robust likelihood-based model,...

Abstract MDM4 is one of the major regulators p53. The biological effect on tumor controversial, its role and molecular mechanism in colon cancer progression prognosis are still unclear. In this study, we identify that significantly overexpressed human high expression was associated with poor mutant inhibits ubiquitination ferroptosis marker protein GPX4 at K167 K191 by upregulating level E3 ubiquitin ligase TRIM21, which promotes polyubiquitination transfer from K48- to K63- linked...

Bladder cancer remains a major challenge in clinical oncology, particularly due to the development of platinum resistance, which severely impacts patient prognosis. Despite numerous attempts create effective prognostic models, their applicability has often been limited. In this study, we utilized robust statistical approach, LASSO-COX regression analysis, develop novel model for bladder based on cisplatin sensitivity-related genes (CSRGs). The was validated using both TCGA-BLCA dataset and...

BACKGROUND: To evaluate the predictive power of somatosensory evoked potentials (SEPs) for minimally conscious state (MCS) in long-term unconscious patients after traumatic brain injury (TBI). METHODS: SEPs were recorded 58 with duration unconsciousness >30 days TBI. classified into three grades. Predictors including age, sex, Glasgow Coma Scale (GCS), and cause also analyzed, respectively. The outcome was divided two groups group MCS group. assessed at 12 months RESULTS: In patients, 22...

Modified Lingguizhugan Decoction (MLD) came from famous Chinese medicine Linggui Zhugan Decoction. The MLD is used for the treatment of metabolic syndrome in clinical setting. Our study focuses on comprehensive incorporated with dietary restriction and exercise a rat model (MS). Rats were divided into five groups: control group (Cont), high-fat diet (HFD), (HFD-DR), (HFD-DR-Ex) (HFD-DR-Ex-MLD). Treatments conducted 1 week after feeding 12 weeks. effects treatments high fat diet-induced...

Abstract Background Recent studies have shown that immunotherapies, including peptide vaccines, remain promising strategies for patients with lower grade glioma (LGG); however new biomarkers need to be developed identify who may benefit from therapy. We aimed investigate the feasibility of liquid biopsy-based gene signatures in predicting prognosis LGG patients, as well benefits immunotherapy. Methods evaluated association between circulating immune cells and treatment response by analyzing...

ABSTRACT Background and Aims As a biomarker of insulin resistance (IR) in patients with acute myocardial infarction (AMI), the triglyceride‐glucose index (TyG index) has received significant attention. However, most research on AMI focused male patients, as it is traditionally believed to primarily affect males. Therefore, this study was conducted female population investigate potential correlation between TyG their outcomes. Methods A total 320 women who were admitted Fujian Provincial...

The purpose of this study is to develop a specific CXCR4-targeting radioiodinated agent (125I- or 131I-pentixather) for single-photon-emission-computed-tomography (SPECT) imaging CXCR4 expression in myocardial-infarction-reperfusion (MI/R) rat models. After SPECT-CT with 125I-pentixather at 4, 12, and 36 h 3 7 days after MI/R, the models were validated by ex vivo autoradiography, TTC staining, immunohistochemistry echocardiography classical 99mTc-MIBI perfusion imaging. images showed that...

Abstract Anwulignan is a monomer compound derived from Schisandra sphenanthera lignans. It has been reported to possess spectrum of pharmacological activities, including anti‐bacterial, anti‐inflammatory, anticancer and hepatoprotective properties. However, its capacity molecular mechanism(s) against non‐small cell lung cancer (NSCLC) have not fully elucidated. significantly inhibited growth increased G1‐phase cycle arrest in NSCLC cells. strongly attenuates the JAK1/STAT3 signalling pathway...

Crush syndrome (CS), alternatively termed traumatic rhabdomyolysis, is a paramount posttraumatic complication. Given the infeasibility of conducting direct simulation research in humans, role animal models pivotal. Regrettably, dearth standardized persists. The objective this study was to construct repeatable rat CS and, based on this, simulate specific clinical scenarios. Methods: Using self-developed multichannel intelligent small-animal crush injury platform, we applied force 5 kg hind...

A ureteric stone is a type of urinary tract that found within the ureter. While most cases can be managed with conservative treatment or minimally invasive surgery, these methods often cause significant pain for patient. Interestingly, new ureteroscope has shown considerable promise in treating patients stones, and this study aims to explore its clinical application. total 120 stones were recruited from our hospitals between January 1, 2023, December 31, 2023. These randomly assigned either...

Accurately inserting pedicle screws is the key point of posterior screw fixation for lower cervical spine (C3-C7) instability. 3D printing technology can improve accuracy placement. This study compared safety 3D-printed flexible drill guiding template vs. traditional rigid insertion.This was a retrospective study. A total 34 patients who underwent from March 2018 to May 2021 were enrolled in this study, and they divided into group group. 18 assisted by printed templates cervix, 16 regular...