A5084871379- Bone Metabolism and Diseases
- Ferroptosis and cancer prognosis
- Bioactive Natural Diterpenoids Research
- MicroRNA in disease regulation
- Animal Nutrition and Physiology
- Animal Virus Infections Studies
- thermodynamics and calorimetric analyses
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Retinal Diseases and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- 3D Printing in Biomedical Research
- Inflammatory mediators and NSAID effects
- Retinal Development and Disorders
- Nutrition, Genetics, and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Microbial Applications in Construction Materials
- Alkaline Phosphatase Research Studies
- Stress Responses and Cortisol
- Bone health and osteoporosis research
- Mesenchymal stem cell research
- Quinazolinone synthesis and applications
- interferon and immune responses
Harbin Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Tongji University
2020-2024
Tongji Hospital
2022-2024
Wenzhou Medical University
2024
Shanghai Mental Health Center
2024
Shanghai Jiao Tong University
2024
Guangzhou University of Chinese Medicine
2014-2017
Diabetic retinopathy (DR) is one of the leading causes blindness in world, and timely prevention treatment are very important. Previously, we found that a neurodegenerative factor, Glia maturation factor-β (GMFB), was upregulated vitreous at early stage diabetes, which may play an important role pathogenesis. Here, high glucose environment, large amounts GMFB protein can be secreted vitreous, translocates ATPase ATP6V1A from lysosome, preventing its assembly alkalinizing lysosome retinal...
Macrophages play a crucial role in atherosclerotic plaque formation, and the death of macrophages is vital factor determining fate atherosclerosis. GSDMD (gasdermin D)-mediated pyroptosis programmed cell death, characterized by membrane pore formation inflammatory release.
Evodiae fructus (EF) has been used in China for thousands of years as an analgesic, antiemetic, anti-inflammatory and antidiarrheal drug. EF is a toxic drug causes hepatotoxicity humans. Although recent chronic toxicity studies performed on aqueous extract revealed that it can produce obvious cumulative hepatotoxicity, the mechanism behind this still uncertain. In present study, we investigated influence oxidative stress, mitochondrial permeability transition, adenosine triphosphate (ATP),...
Modified Lingguizhugan Decoction (MLD) came from famous Chinese medicine Linggui Zhugan Decoction. The MLD is used for the treatment of metabolic syndrome in clinical setting. Our study focuses on comprehensive incorporated with dietary restriction and exercise a rat model (MS). Rats were divided into five groups: control group (Cont), high-fat diet (HFD), (HFD-DR), (HFD-DR-Ex) (HFD-DR-Ex-MLD). Treatments conducted 1 week after feeding 12 weeks. effects treatments high fat diet-induced...
Schizophrenia significantly impacts cognitive and behavioral functions is primarily treated with second-generation antipsychotics (SGAs) such as olanzapine. Despite their efficacy, these drugs are linked to serious metabolic side effects which can diminish patient compliance, worsen psychiatric symptoms increase cardiovascular disease risk. This study explores the hypothesis that SGAs affect molecular determinants of synaptic plasticity brain activity, particularly focusing on lateral septum...
Abstract An imbalance between the adipogenesis and osteogenesis of bone marrow mesenchymal stem cells (BMSCs) is considered basic pathogenesis osteoporosis. Although actin cytoskeleton remodelling plays a crucial role in differentiation BMSCs, BMSCs postmenopausal osteoporosis (PMOP) has remained elusive. Glia maturation factor-beta (GMFB) unique polymerization/depolymerization cycles actin. We observed that GMFB expression was increased tissue from both ovariectomized (OVX) rats PMOP...
The marine‑derived oxalicumone A (POA) has been demonstrated as a potent anti‑tumor bioactive agent for variety of human carcinoma, but to the best our knowledge, remains be evaluated in healthy liver cells. As many drugs distribute preferentially liver, present study aimed investigate effects POA on apoptosis, oxidative stress and mitochondrial function L‑02 Cell‑Counting kit‑8 assay that inhibits proliferation cells dose‑ time‑dependent manner. Furthermore, induced apoptosis by increasing...
Abstract Excessive osteoclast activation, which depends on dramatic changes in actin dynamics, causes osteoporosis (OP). The molecular mechanism of activation OP related to type 1 diabetes (T1D) remains unclear. Glia maturation factor beta (GMFB) is considered a growth and differentiation for both glia neurons. Here, we demonstrated that Gmfb deficiency effectively ameliorated the phenotype T1D-OP rats by inhibiting hyperactivity. In vitro assays showed GMFB participated rather than...
Oxalicumone A (POA), a novel dihydrothiophene-condensed chromone, was isolated from the marine‑derived fungus Penicillium oxalicum. Previous reports demonstrated that POA exhibits strong activity against human carcinoma cells, thus it has been suggested as bioactive anticancer agent. To research toxic effect of on cultured normal epithelial kidney‑2 (HK‑2) cells and evaluate its clinical safety, cell survival evaluated by Cell Counting Kit-8 assay apoptosis Hoechst 33258 staining, flow...
Summary To investigate the changes in liver triglyceride (TG) metabolism broiler chickens with cold-induced ascites syndrome (AS), 216 one-day-old male Ross 308 chicks were randomly allocated into two treatment groups (control and AS) 6 replicates. Starting on day 14, birds AS group exposed to low ambient temperature (17°C during daytime 14°C at night) induce AS.
Abstract Retinal degeneration, characterized by Müller cell gliosis and photoreceptor apoptosis, is considered an early event in diabetic retinopathy (DR). Our previous study proposed that GMFB may mediate retinal degeneration. This identified as a sensitive functional marker for DR. Compared to the wild type (WT) group, Gmfb knockout (KO) significantly improved visual function, attenuated gliosis, reduced apoptosis of neurons, decreased mRNA levels tumor necrosis factor α ( Tnf‐α )...
Recent evidence suggests that glia maturation factor β (GMFβ) is important in the pathogenesis of pulmonary arterial hpertension (PAH), but underlying mechanism unknown. To clarify whether GMFβ can be involved vascular remodeling and to explore role IL-6-STAT3 pathway this process, expression PAH rats examined downstream molecules including periostin (POSTN) interleukin-6 (IL-6) measured using real-time quantitative polymerase chain reaction (RT-qPCR) western blot analysis. The location...
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL) receptors, leading their degradation and decreasing serum LDL-cholesterol (LDL-C) reduce risk of coronary heart disease. We aimed investigate the safety, tolerability, pharmacodynamic characteristics RN0191, a novel structure small interfering RNA that inhibits PCSK9 mRNA translation process, in healthy Chinese adults with elevated LDL-C who were not on lipid-lowering treatment. Methods:...
Summary Cholesterol is essential for life, and disorders related to cholesterol metabolism may become metabolic diseases. To investigate the changes that occur in broiler chickens with cold-induced ascites syndrome (AS), 216 one-day-old male broilers were randomly assigned two groups (Control AS), 6 replicates of 18 birds each. Starting on day 14, AS group exposed low ambient temperatures (17°C during daytime 14°C at night) induce AS.