A5048353685- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Advanced biosensing and bioanalysis techniques
- Renal cell carcinoma treatment
- Bioactive Natural Diterpenoids Research
- Chronic Kidney Disease and Diabetes
- Arsenic contamination and mitigation
- Quantum Dots Synthesis And Properties
- Adipokines, Inflammation, and Metabolic Diseases
- Innovative Microfluidic and Catalytic Techniques Innovation
- Adipose Tissue and Metabolism
- MRI in cancer diagnosis
- Aerogels and thermal insulation
- Advanced Proteomics Techniques and Applications
- Microbial Natural Products and Biosynthesis
- Diet and metabolism studies
- TGF-β signaling in diseases
- Analytical Chemistry and Chromatography
- Lung Cancer Treatments and Mutations
- Microbial Applications in Construction Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Melanoma and MAPK Pathways
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
Cancer Hospital of Shantou University Medical College
2021-2024
Shantou University
2021-2024
Guangzhou University of Chinese Medicine
2017-2019
Purpose The prognostic value of serum cystatin-C (Cys-C) in renal cell carcinoma (RCC) remains unknown. purpose this study is to explore the Cys-C for RCC patients. Patients and methods levels preoperative Cys-C, creatinine (CRE) estimated glomerular filtration rate (e-GFR) were retrospectively collected 325 patients undergoing surgery. cutoff values CRE e-GFR determined by standardized Cutoff Finder algorithm. receiver operating characteristic (ROC) curve pairwise comparison performed...
Modified Lingguizhugan Decoction (MLD) came from famous Chinese medicine Linggui Zhugan Decoction. The MLD is used for the treatment of metabolic syndrome in clinical setting. Our study focuses on comprehensive incorporated with dietary restriction and exercise a rat model (MS). Rats were divided into five groups: control group (Cont), high-fat diet (HFD), (HFD-DR), (HFD-DR-Ex) (HFD-DR-Ex-MLD). Treatments conducted 1 week after feeding 12 weeks. effects treatments high fat diet-induced...
Cystatin-C (Cys-C) has been studied as a valuable prognostic indicator in several malignancies. The goal of this study is to explore the expression and significance Cys-C clear cell renal carcinoma (CCRCC).Immunohistochemistry western blot assays were performed evaluate level CCRCC tissue. Expression levels tissue samples relation clinicopathological characteristics tumors assessed. Their was analyzed by univariate multivariate analyses. In addition, 786-O lines inhibited using CRISPR/Case9...
Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has gained increased attention in the metabolic characterization of human biofluids. However, stability and reproducibility nanoparticle-based substrates remain two biggest challenges high-salt environments. Here, by controlling extent Coulomb repulsion 26 nm positively charged AuNPs, a homogeneous layer covalently bonded AuNPs on coverslip with tunable interparticle distances down to 16 been successfully fabricated...
High-throughput biofluid metabolomics analysis for screening life-threatening diseases is urgently needed. However, the high salt content of samples, which introduces severe interference, can greatly limit throughput. Here, a new 3-D interconnected hierarchical superstructure, namely "plasmonic gold-on-silica (Au/SiO2) double-layered aerogel", integrating distinctive features an upper plasmonic gold aerogel with lower inert silica was successfully developed to achieve in situ separation and...
The detection of cations plays a significant role in environmental, pharmaceutical, and clinical analysis. In this study, uniform Au nanoparticle/PbSe quantum dot heterostructure that promotes the desorption variety cationic analytes (e.g., malachite green, berberine, choline) was designed based on layer-by-layer assembly strategy. fabrication process involved applying monolayer AuNPs to derivatized coverslip, followed by depositing second layer PbSe QDs. Through...
The marine‑derived oxalicumone A (POA) has been demonstrated as a potent anti‑tumor bioactive agent for variety of human carcinoma, but to the best our knowledge, remains be evaluated in healthy liver cells. As many drugs distribute preferentially liver, present study aimed investigate effects POA on apoptosis, oxidative stress and mitochondrial function L‑02 Cell‑Counting kit‑8 assay that inhibits proliferation cells dose‑ time‑dependent manner. Furthermore, induced apoptosis by increasing...
Lung cancer (LC) is a major cause of mortality among malignant tumors. Early diagnosis through lipidomic profiling can improve prognostic outcomes. In this study, uniform PbS/Au-layered substrate that enhances the laser desorption/ionization process, an interfacial process triggered on surface upon excitation, was designed to efficiently characterize profiles LC patient serum. By controlling stacking arrangement and particle sizes PbS QDs AuNPs, optimized promotes generation excited...
An increasing amount of evidence has proven that serum metabolites can instantly reflect disease states. Therefore, sensitive and reproducible detection in a high-throughput manner is urgently needed for clinical diagnosis. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) platform metabolite detection, but it hindered by significant signal fluctuations because the "sweet spot" effect organic matrices. Here, screening two transformation methods four normalization...
Oxalicumone A (POA), a novel dihydrothiophene-condensed chromone, was isolated from the marine‑derived fungus Penicillium oxalicum. Previous reports demonstrated that POA exhibits strong activity against human carcinoma cells, thus it has been suggested as bioactive anticancer agent. To research toxic effect of on cultured normal epithelial kidney‑2 (HK‑2) cells and evaluate its clinical safety, cell survival evaluated by Cell Counting Kit-8 assay apoptosis Hoechst 33258 staining, flow...