A5039655034- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Bone health and treatments
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Mass Spectrometry Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Brain Metastases and Treatment
- Colorectal Cancer Treatments and Studies
- Advanced biosensing and bioanalysis techniques
- Hepatitis B Virus Studies
- Metabolomics and Mass Spectrometry Studies
- Heavy Metal Exposure and Toxicity
Jinan University
2025
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Shantou University
2011-2024
Cancer Hospital of Shantou University Medical College
2011-2024
OncoImmune (United States)
2024
Beijing Children’s Hospital
2024
Capital Medical University
2024
Bristol-Myers Squibb (United States)
2016-2023
Nivolumab monotherapy is approved in the United States for third-line or later metastatic small cell lung cancer based on pooled data from nonrandomized and randomized cohorts of multicenter, open-label, phase 1/2 trial nivolumab ± ipilimumab (CheckMate 032; NCT01928394). We report updated results, including long-term overall survival (OS), cohort.Patients with disease progression after one to two prior chemotherapy regimens were 3:2 3 mg/kg every 2 weeks 1 plus four cycles followed by...
In extensive-disease small-cell lung cancer (ED-SCLC), response rates to first-line platinum-based chemotherapy are robust, but responses lack durability. CheckMate 451, a double-blind phase III trial, evaluated nivolumab plus ipilimumab and monotherapy as maintenance therapy following for ED-SCLC.Patients with ED-SCLC, Eastern Cooperative Oncology Group performance status 0-1, no progression after ≤ 4 cycles of were randomly assigned (1:1:1) 1 mg/kg 3 once every weeks 12 followed by 240 mg...
Abstract Background In this phase Ib/II open-label study, tumor immune suppression was targeted in patients with advanced refractory solid tumors and recurrent/refractory non-small cell lung cancer (NSCLC) using galunisertib nivolumab. Methods Eligible were ≥ 18 years old, had an Eastern Cooperative Oncology Group performance status ≤ 1, treatment-naive for anti-programmed death-1, its ligand, or transforming growth factor β receptor 1 kinase inhibitors. Phase Ib open-label, dose-escalation...
Within the global architecture, engineering, and construction industry, use of Building Information Modeling (BIM) technology has significantly expanded. However, given unique characteristics road infrastructure, application BIM is still being explored. This article focuses on Yuanchen Expressway, exploring innovative applications in comprehensive management. The project employs advanced technologies, including BIM, Geographic Systems (GIS), Internet Things (IoT), to precisely identify...
Abstract Purpose: Clonal architecture is fundamental for the understanding of cancer biology and therapy; however, multiregional sampling in advanced-stage cancers not always applicable. This prospective clinical trial was to investigate whether paired tissue circulating tumor DNA (ctDNA) could describe clonal advanced non–small cell lung (NSCLC) its association with outcome (NCT03059641). Patients Methods: Paired plasma ctDNA samples were sequenced by target-capture deep sequencing 1,021...
Terpenes are potentially harmful substances that associated with endocrine disruption due to their ability produce oxidizers, aldehydes, and secondary aerosol particles. However, the exact association between terpenoids metabolic syndrome remains unclear. This study aims examine relationship individual mixed exposure terpene compounds risk of developing syndrome. We utilized data from NHANES 2013-2014 cycle, including 1,135 participants. Multiple regression models, Bayesian kernel (BKMR),...
8561 Background: Approved first-line therapies of PD-L1/PD-1 inhibitors plus chemotherapy conferred significant survival benefits for advanced squamous non-small cell lung cancer (sqNSCLC). However, the prognosis remains to be improved. The epidermal growth factor receptor (EGFR) is highly expressed in sqNSCLC and associated with a poor prognosis. This study aimed compare efficacy HLX07, novel humanized anti-EGFR antibody, serplulimab (anti-PD-1 antibody) ± chemo versus as option sqNSCLC....
Background Retrospective studies have suggested a potential risk of hyperprogressive disease (HPD) in patients receiving immune checkpoint inhibitors (ICIs). We compared the incidence HPD during treatment with nivolumab±ipilimumab versus natural tumor progression placebo post hoc analyses two randomized, double-blind clinical trials. Methods ATTRACTION-2 randomized advanced gastric or gastroesophageal junction cancer (GC/GEJC) and on ≥2 prior regimens to nivolumab 3 mg/kg Q2W placebo....
Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has gained increased attention in the metabolic characterization of human biofluids. However, stability and reproducibility nanoparticle-based substrates remain two biggest challenges high-salt environments. Here, by controlling extent Coulomb repulsion 26 nm positively charged AuNPs, a homogeneous layer covalently bonded AuNPs on coverslip with tunable interparticle distances down to 16 been successfully fabricated...
Developing permanent magnets based on full high abundance rare-earth (RE) elements of Ce, La, and Y offers tremendous potential for the balanced utilization RE resources, but magnetic properties these are restricted due to dilution caused by existence paramagnetic REFe2 laves phase. Herein, non-RE element Ge with efficiency was introduced enhance performance Ce-, La-, Y-based RE–Fe–B nanocrystalline alloys, highest maximum energy product [(BH)max] 65.6 kJ/m3 an enhanced coercivity (Hcj) 346...
The detection of cations plays a significant role in environmental, pharmaceutical, and clinical analysis. In this study, uniform Au nanoparticle/PbSe quantum dot heterostructure that promotes the desorption variety cationic analytes (e.g., malachite green, berberine, choline) was designed based on layer-by-layer assembly strategy. fabrication process involved applying monolayer AuNPs to derivatized coverslip, followed by depositing second layer PbSe QDs. Through...
Lung cancer (LC) is a major cause of mortality among malignant tumors. Early diagnosis through lipidomic profiling can improve prognostic outcomes. In this study, uniform PbS/Au-layered substrate that enhances the laser desorption/ionization process, an interfacial process triggered on surface upon excitation, was designed to efficiently characterize profiles LC patient serum. By controlling stacking arrangement and particle sizes PbS QDs AuNPs, optimized promotes generation excited...
<h3>Background</h3> Most patients with advanced solid tumors relapse after T-cell checkpoint blockade despite of immunotherapy becoming the mainstream approvals inhibitors. Myeloid inhibition is a new approach to immunotherapy. Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) myeloid its expression restricted monocytes or monocyte-derived cells<sup>1,2,3</sup> and in normal antigen presenting cells. LILRB4 functions as negative regulator immunity through interaction...
An increasing amount of evidence has proven that serum metabolites can instantly reflect disease states. Therefore, sensitive and reproducible detection in a high-throughput manner is urgently needed for clinical diagnosis. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) platform metabolite detection, but it hindered by significant signal fluctuations because the "sweet spot" effect organic matrices. Here, screening two transformation methods four normalization...
Abstract We aim to evaluate whether different definitions of esophagus (DEs) impact on the esophageal toxicity prediction for cancer (EC) patients administered intensity-modulated radiation therapy with simultaneous integrated boost (SIB-IMRT) vs. standard-dose IMRT (SD-IMRT). The 21 diagnosed primary EC were defined in following four ways: whole esophagus, including tumor (ESO ); ESO within treatment field infield , excluding infield-tumor ) and whole-tumor ). difference dose variation,...
Abstract This study aims to investigate the significant relationship between serum heavy metals (lead [Pb], cadmium [Cd], mercury [Hg]) and risk of herpes simplex virus type 1 (HSV‐1) infection. Data were derived from National Health Nutrition Examination Survey (NHANES) conducted in United States 2007 2016. nationally representative survey, by Center for Statistics, assessed health status participants through interviews, physical examinations, laboratory tests. After excluding lacking Pb,...
Purpose In this first-in-human dose escalation study, the safety and efficacy of IO-108, a fully human monoclonal antibody targeting leukocyte immunoglobulin-like receptor B2 (LILRB2), was investigated in patients with advanced solid tumors as monotherapy combination pembrolizumab, an anti-programmed cell death protein 1 (PD-1) antibody. Methods The study included histologically or cytologically confirmed relapsed tumors, measurable disease by Response Evaluation Criteria Solid Tumors...