A5114375952- Alzheimer's disease research and treatments
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Estrogen and related hormone effects
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Neurotransmitter Receptor Influence on Behavior
- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Cerebral Palsy and Movement Disorders
- Parkinson's Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Traditional Chinese Medicine Analysis
- Sulfur Compounds in Biology
- Nicotinic Acetylcholine Receptors Study
- Medicinal Plants and Neuroprotection
Bengbu Medical College
2021-2025
Shanghai Mental Health Center
2025
Shanghai Jiao Tong University
2025
Yibin University
2025
James J. Peters VA Medical Center
2015-2024
Icahn School of Medicine at Mount Sinai
2013-2024
Qingdao University
2023-2024
Shengli Oilfield Central Hospital
2021-2024
Taian City Central Hospital
2024
Second Affiliated Hospital of Nanjing Medical University
2024
Nicotinamide adenine dinucleotide (NAD)+-dependent sirtuins have been identified to be key regulators in the lifespan extending effects of calorie restriction (CR) a number species. In this study we report for first time that promotion NAD+-dependent sirtuin, SIRT1-mediated deacetylase activity, may mechanism by which CR influences Alzheimer disease (AD)-type amyloid neuropathology. Most importantly, predicted attenuation beta-amyloid content brain during can reproduced mouse neurons vitro...
Alzheimer9s disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) Aβ oligomers has been proposed to be largely responsible for AD dementia deficits the Tg2576 mice, model AD. In this study, we found that naturally derived grape seed polyphenolic extract can significantly inhibit amyloid β-protein aggregation into <i>in vitro</i>. When orally administered preparation...
Recent epidemiological evidence suggests that some antihypertensive medications may reduce the risk for Alzheimer disease (AD). We screened 55 clinically prescribed AD-modifying activity using primary cortico-hippocampal neuron cultures generated from Tg2576 AD mouse model. These agents represent all drug classes used hypertension pharmacotherapy. identified 7 candidate significantly reduced AD-type β-amyloid protein (Aβ) accumulation. Through in vitro studies, we found only 1 of drugs,...
Abstract Major depressive disorder is associated with abnormalities in the brain and immune system. Chronic stress animals showed that epigenetic inflammatory mechanisms play important roles mediating resilience susceptibility to depression. Here, through a high-throughput screening, we identify two phytochemicals, dihydrocaffeic acid (DHCA) malvidin-3′- O -glucoside (Mal-gluc) are effective promoting against by modulating synaptic plasticity peripheral inflammation. DHCA/Mal-gluc also...
Grape seed polyphenol extract (GSPE) is receiving increasing attention for its potential preventative and therapeutic roles in Alzheimer's disease (AD) other age-related neurodegenerative disorders. The intestinal microbiota known to actively convert many dietary polyphenols, including GSPE, phenolic acids. There limited information on the bioavailability bioactivity of GSPE-derived acid brain.We orally administered GSPE rats investigated 12 acids be generated by metabolism anthocyanidins....
Epidemiological evidence suggests that moderate consumption of red wine reduces the incidence Alzheimer disease (AD). To study protective effects wine, experiments recently were executed in Tg2576 mouse model AD. These studies showed a commercially available grape seed polyphenolic extract, MegaNatural-AZ (MN), significantly attenuated AD-type cognitive deterioration and reduced cerebral amyloid deposition (Wang, J., Ho, L., Zhao, W., Ono, K., Rosensweig, C., Chen, Humala, N., Teplow, D. B.,...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and finally death. ALS patients suffer from asthenia their weakness negatively impacts quality life, limiting daily activities. They have impaired energy balance linked to lower activity mitochondrial electron transport chain enzymes in spinal cord, suggesting that improving function may present therapeutic approach for ALS. When fed ketogenic diet, the G93A...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects spinal cord and cortical motor neurons. An increasing amount of evidence suggests mitochondrial dysfunction contributes to neuron death in ALS. Peroxisome proliferator-activated receptor gamma co-activator-1α (PGC-1α) principal regulator biogenesis oxidative metabolism.In this study, we examined whether PGC-1α plays protective role ALS by using double transgenic mouse model where over-expressed an...
Alzheimer's disease (AD) is the most prevalent neurodegenerative of aging and currently has no cure. Its onset progression are influenced by multiple factors. There growing consensus that successful treatment will rely on simultaneously targeting pathological features AD. Polyphenol compounds have many proven health benefits. In this study, we tested hypothesis combining three polyphenolic preparations (grape seed extract, resveratrol, Concord grape juice extract), with different...
We recently found that moderate consumption of two unrelated red wines generate from different grape species, a Cabernet Sauvignon and muscadine wine are characterized by distinct component composition polyphenolic compounds, significantly
Forkhead transcription factor FoxO3a, also known as DAF‐16 in Caenorhabditis elegans , is a key regulator of the insulin receptor (IR)/insulin‐like growth factor‐I signaling pathway mediated extension life span worms and yeast. In this study, we report that calorie restriction (CR)‐mediated activation IR leads to hyperphosphorylation FoxO3a and, consequently, its exclusion from nucleus. This inactivation activity correlated with attenuation Alzheimer's disease (AD)‐type amyloid...
Recent studies suggest that certain cardiovascular antihypertensive agents decrease the incidence of Alzheimer's disease. Based on this evidence and fact Abeta aggregation into high-molecular-weight-soluble oligomeric species is known to directly induce cognitive impairment, we tested possibility compounds may affect progression disease, at least in part by influencing formation oligomers. High throughput screening 55 commercially available drugs identified four significantly reduced...
Abstract Hydrogen sulfide, generated in the myocardium predominantly via cystathionine-γ-lyase (CSE), is cardioprotective. Our previous study has shown that estrogens enhance CSE expression of female rats. The present aims to explore mechanisms by which regulate expression, particular clarify role estrogen receptor subtypes and transcriptional factor responsible for estrogenic effects. We found either inhibitor or small interfering RNA attenuated protective effect 17β-estradiol (E2) against...
Evodiae fructus (EF) has been used in China for thousands of years as an analgesic, antiemetic, anti-inflammatory and antidiarrheal drug. EF is a toxic drug causes hepatotoxicity humans. Although recent chronic toxicity studies performed on aqueous extract revealed that it can produce obvious cumulative hepatotoxicity, the mechanism behind this still uncertain. In present study, we investigated influence oxidative stress, mitochondrial permeability transition, adenosine triphosphate (ATP),...
There is accumulating evidence that coffee consumption may reduce risk for type 2 diabetes, a known factor Alzheimer's and other neurological diseases. Coffee also associated with reduced disease non-Alzheimer's dementias. However, preventive therapeutic development of complicated by the cardiovascular side effects caffeine intake. As rich source chlorogenic acids many bioactive compounds than caffeine, we hypothesized decaffeinated drinks exert beneficial on brain.We have investigated...