A5100652493- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Renal Transplantation Outcomes and Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Transplantation: Methods and Outcomes
- Immune cells in cancer
- RNA modifications and cancer
- Dialysis and Renal Disease Management
- Cancer, Lipids, and Metabolism
- Genetic and Kidney Cyst Diseases
- Urological Disorders and Treatments
- Immune Response and Inflammation
- Colorectal Cancer Treatments and Studies
- Urinary Bladder and Prostate Research
- Asthma and respiratory diseases
- Renal and Vascular Pathologies
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Acute Kidney Injury Research
Capital Medical University
2016-2025
Beijing Chao-Yang Hospital
2015-2025
Yunnan University of Traditional Chinese Medicine
2025
Guangzhou University of Chinese Medicine
2025
Beijing Children’s Hospital
2010-2025
First People's Hospital of Foshan
2015-2025
Beijing Anzhen Hospital
2025
Zaozhuang Municipal Hospital
2024
Jiangsu Province Hospital
2012-2024
Lanzhou University
2024
This study sought to evaluate the safety and efficacy of rosuvastatin in preventing contrast-induced acute kidney injury (CI-AKI) patients with diabetes mellitus (DM) chronic disease (CKD).CI-AKI is an important complication after contrast medium injection. While small studies have shown positive results statin therapy, role therapy prevention CI-AKI remains unknown.We randomized 2,998 type 2 DM concomitant CKD who were undergoing coronary/peripheral arterial angiography or without...
Human urine-derived stem cells (USCs)-derived exosomes (USC-Exo) could improve kidney ischemia/reperfusion injury (IRI), while the underlying mechanisms of this protective effect remain unclear.Human USCs and USC-Exo were isolated verified by morphology specific biomarkers. The effects on ferroptosis detected in IRI-induced acute (AKI) model C57BL/6 mice. lncRNA taurine-upregulated gene 1 (TUG1) hypoxia/reoxygenation (H/R)-treated human proximal tubular epithelial (HK-2). interaction SRSF1...
Podocytes are essential to maintain the normal filtration function of glomerular basement membrane, which could be injured by ischemia-reperfusion. As complicated autophagy in terminal differentiated podocytes, dysfunction might contribute I/R induced renal following membrane (GFM) injuries. Meanwhile, apelin-13, an endogenous polypeptide, has been proved effective regulating and apoptosis podocytes. Therefore, it is hypothesized that apelin-13 may protect podocytes from IRI inhibiting...
Abstract Background Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular pathways involved in human platelet-mediated NET generation remain poorly defined. Circulating plasma exosomes mostly originating from platelets may induce vascular apoptosis myocardial dysfunction sepsis; however, their role remains unclear. This study aimed detect whether platelet-derived could promote septic shock...
Background Ischemia reperfusion injury (IRI) is an inevitable process in renal transplantation, which closely related to serious postoperative complications such as delayed graft function (DGF), acute rejection and failure. Neutrophil extracellular traps (NETs) are DNA structures decorated with various protein substances released by neutrophils under strong signal stimulation. Recently, NETs have been found play important role the of IRI. This study aimed comprehensively analyze expression...
Abstract Interstitial cystitis (IC) is a severely debilitating and chronic disorder with unclear etiology pathophysiology, which makes the diagnosis difficult treatment challenging. To investigate role of immunity in IC bladders, we sequenced 135,091 CD45 + immune cells from 15 female patients 9 controls stress urinary incontinence using single-cell RNA sequencing (scRNA-seq). 22 subpopulations were identified constructed landscape. Among them, M2-like macrophages, inflammatory CD14...
Abstract In hepatocellular carcinoma (HCC), immunotherapy is vital for advanced-stage patients. However, diverse individual responses and tumor heterogeneity have resulted in heterogenous treatment outcomes. Our mechanistic investigations identified LAPTM4B as a crucial gene regulated by ETV1 (a transcription factor), especially liver cancer stem cells (LCSCs). The influence of on LCSCs mediated via the Wnt1/c-Myc/β-catenin pathway. CXCL8 secretion drove myeloid-derived suppressor cell...
Although immunotherapy is effective in improving the clinical outcomes of patients with bladder cancer (BC), it only a small percentage patients. Intercellular crosstalk tumor microenvironment strongly influences patient response to immunotherapy, while patterns plasma cells (PCs) as endogenous antibody-producing remain unknown. Here, we aimed explore heterogeneity PCs and their potential BC cells.
To compare outcomes in patients treated with radiofrequency ablation (RFA) and partial nephrectomy (PN) for clinical T1a renal-cell carcinoma (RCC) a propensity-score matched cohort.We conducted retrospective review of the records all who underwent RFA or between February 2005 December 2009 our institution. The Kaplan-Meier method was used to generate survival curves that were compared log-rank test. Univariable multivariable regression analyses performed determine predictors survival.A...
Background. MSC-derived extracellular vehicles (EVs) exhibit a protective functional role in renal ischemia/reperfusion injury (RIRI). Recent studies have revealed that mitophagy could be potential target process the treatment of RIRI. However, whether EVs are involved regulation RIRI remains largely unknown to date. Methods. model was established vivo mice by subjecting them ischemia/reperfusion. TCMK-1 cells were subjected hypoxia/reoxygenation (H/R) stimulation mimic vitro. BMSCs and...