A5109176070- Apelin-related biomedical research
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Radiation Dose and Imaging
- Nuclear Receptors and Signaling
- Digital Radiography and Breast Imaging
- Paraoxonase enzyme and polymorphisms
- Radiology practices and education
- Kruppel-like factors research
- Lipid metabolism and disorders
- Phonocardiography and Auscultation Techniques
- Ultrasound in Clinical Applications
Capital Medical University
2024-2025
Shanghai Tenth People's Hospital
2020
Shanghai Public Health Clinical Center
2020
Tongji University
2020
Fudan University
2020
University of Alabama at Birmingham
2014
Memorial Sloan Kettering Cancer Center
2008
Podocytes are essential to maintain the normal filtration function of glomerular basement membrane, which could be injured by ischemia-reperfusion. As complicated autophagy in terminal differentiated podocytes, dysfunction might contribute I/R induced renal following membrane (GFM) injuries. Meanwhile, apelin-13, an endogenous polypeptide, has been proved effective regulating and apoptosis podocytes. Therefore, it is hypothesized that apelin-13 may protect podocytes from IRI inhibiting...
Glomerular basement membrane (GBM) thickening, the earliest morphological change of diabetic nephropathy (DN), is related to glomerular endothelial cells (GECs) dysfunction which increase extracellular matrix (ECM) synthesizing. Apelin, endogenous ligand for apelin/apelin receptor (APJ), reported alleviate cell in DN. Therefore, it was hypothesized that apelin/APJ reduced GBM thickening by decreasing synthesis ECM GECs. The results showed apelin fibrosis and expression laminin collagen IV...
Purpose: To compare 3D reconstructed dose of IMRT plans from diode array measurements with in anthropomorphic phantoms. Methods: Six were created for the IROC Houston (RPC) head and neck (H&N) lung phantoms following planning protocols. The included flattened unflattened beam energies ranging 6 MV to 15 both static dynamic MLC tecH&Niques. Each plan was delivered three times respective phantom, each which contained thermoluminescent dosimeters (TLDs) radiochromic films (RCFs). also a...
Purpose: Dedicated small‐animal imaging devices are being used more frequently for translational molecular studies. However, few studies have investigated the magnitude of animal motion during extended dynamic or precision repositioning in multi‐modality and/or serial protocols. The objective this work was to determine positional accuracy and with which tumors situ can be reliably reproducibly imaged on dedicated equipment. Method Materials: A custom rodent cradle a stereotactic template...
Purpose: To optimize the correlation between interstitial pO 2 readings and PET‐derived concentrations in tumors using co‐registered Gd‐DTPA DCE‐MRI to distinguish viable necrotic tumor cells. Method Materials: Nude rats with Dunning R3327‐AT xenografts were positioned a custom‐fabricated mold imaged by (1) T2‐weighted MRI imaging; (2) following IV injection of gadopentetate dimeglumine; (3) microPET for 1/2 hr post‐IV or . The PET images used direct intra‐tumoral measurements an...
Purpose: To establish a criterion for distinguishing viable and necrotic tumor cells using the initial relative slope of Gd‐DTPA DCE‐MRI to apply this optimize specificity hypoxia imaging based on PET. Method Materials: Three nude rats with Dunning R3327‐AT prostate adenocarcinoma xenografts were imaged by dynamic MRI following tail vein injection gadopentetate dimeglumine, parameters 1‐mm slice thickness, 0.5‐mm spacing, 0.13mm × voxel size. The time‐intensity curve each was obtained at...
Abstract: