A5010914355- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Childhood Cancer Survivors' Quality of Life
- Advances in Oncology and Radiotherapy
- MRI in cancer diagnosis
- Colorectal and Anal Carcinomas
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Pituitary Gland Disorders and Treatments
- Radiation Effects in Electronics
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Brain Tumor Detection and Classification
- Prostate Cancer Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
St. Jude Children's Research Hospital
2018-2024
Duke Medical Center
2015-2020
University of Tennessee Health Science Center
2020
Duke University
2018
University of Colorado Denver
2017-2018
The University of Texas MD Anderson Cancer Center
2011-2017
University of Houston
2017
The University of Texas Health Science Center at Houston
2014
Thomas Jefferson University Hospital
2011-2012
Washington University in St. Louis
2011-2012
4DCT-ventilation is an exciting new imaging modality that uses 4DCT data to calculate lung-function maps. Because 4DCTs are acquired as standard of care for lung cancer patients undergoing radiotherapy, 4DCT-ventiltation provides functional information at no extra dosimetric or monetary cost the patient. The development clinical trials underway use spare in radiotherapy. purpose this work was perform a virtual trial using retrospective develop practical aspects avoidance trial.The study...
To characterize the association between neurocognitive outcomes (memory and processing speed) radiation (RT) dose to hippocampus, corpus callosum (CC), frontal white matter (WM) in children with medulloblastoma treated on a prospective study, SJMB03.
The Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) system was the first published radiation therapy (RT)-compatible to reduce need for pediatric anesthesia through video-based distraction. We evaluated feasibility of AVATAR implementation and effects on use, quality life, anxiety a multicenter trial.Pediatric patients 3 10 years age preparing undergo RT at institutions were prospectively enrolled. Children able least 1 fraction using without considered successful (S)....
The recent development of multifocal stereotactic radiosurgery (SRS) using a single isocenter volumetric modulated arc theory (VMAT) technique warrants re-examination the quality assurance (QA) tolerances for routine mechanical QA recommended by American Association Physicists in Medicine Task Group Report Number 142. Multifocal SRS can result targets with small volumes being at large off-axis distance from treatment isocenter. Consequently, angular errors collimator, patient support...
An anthropomorphic head phantom, constructed from a water-equivalent plastic shell with only spherical target, was modified to include nonspherical target (pituitary) and an adjacent organ at risk (OAR) (optic chiasm), within 2 mm, simulating the anatomy encountered when treating acromegaly. The OAR spatial proximity provided more realistic treatment planning dose delivery exercise. A separate dosimetry insert contained two TLD for absolute radiochromic film, in sagittal coronal planes,...
Challenges in proton therapy include identifying patients most likely to benefit; ensuring consistent, high-quality plans as its adoption becomes more widespread; and recognizing biological uncertainties that may be related increased relative biologic effectiveness driven by linear energy transfer (LET). Knowledge-based planning (KBP) is a domain help address all three.
Abstract Purpose Independent calculations of proton therapy plans are an important quality control procedure in treatment planning. When using custom Monte Carlo (MC) models the beamline, deploying can be laborious, time consuming, and require in‐depth knowledge computational environment. We developed automated framework to remove these barriers integrate our MC model into clinical workflow. Materials Methods The Eclipse Scripting Application Programming Interface was used initiate...
The primary objective is to evaluate the potential dosimetric gains of performing functional avoidance-based proton treatment planning using 4DCT derived ventilation imaging. data 31 patients from a prospective avoidance clinical trial were evaluated with intensity modulated therapy (IMPT) plans and compared volumetric arc (VMAT) plans. Dosimetric parameters between standard IMPT VMAT one-way analysis variance post hoc paired student t-test. Normal Tissue Complication Probability (NTCP)...
Image-based data mining (IBDM) is a novel voxel-based method for analyzing radiation dose responses that has been successfully applied in adult data. Because anatomic variability and side effects of interest differ children compared to adults, we investigated the feasibility IBDM pediatric analyses.We tested with CT images distributions collected from 167 (aged 10 months 20 years) who received proton radiotherapy primary brain tumors. We used four reference patients assess sensitivity...
A form of lung functional imaging has been developed that uses 4DCT data to calculate ventilation (4DCT-ventilation). Because 4DCTs are acquired as standard-of-care manage breathing motion during radiotherapy, 4DCT-ventilation provides information at no extra dosimetric or monetary cost. yet be described in children. can used a tool help assess post-treatment function and predict for future clinical thoracic toxicities pediatric patients receiving radiotherapy the chest. The purpose this...
Background Cerebral vessel diameter changes objectively and automatically derived from longitudinal magnetic resonance angiography (MRA) facilitate quantification of further modeling. Purpose To characterize in intracranial using time‐of‐flight (TOF) MRA. Study Type Retrospective study. Subject Population IN all, 112 pediatric patients, aged 9.96 ± 4.59 years, with craniopharyngioma 2006–2011 scanned annually. Field Strength/Sequence 1.5T 3T TOF Statistical Tests Chi‐square...
We quantified the effect of various forward-based treatment-planning strategies in proton therapy on dose-weighted linear energy transfer (LETd). By maintaining dosimetric quality at a clinically acceptable level, we aimed to evaluate differences LETd among approaches and their practicality minimizing biologic uncertainties associated with LETd.Eight that are achievable commercial systems were applied cylindrical water phantom four pediatric brain tumor cases. Each planning strategy was...
PurposeWhole lung irradiation (WLI) is indicated for certain pediatric patients with metastases. This study investigated whether WLI delivered as intensity-modulated proton therapy (IMPT) could significantly spare the heart and breasts when compared conventional anteroposterior/posteroanterior photon fields (IMRT) WLI.
Purpose: Development of a novel on‐line dosimetry tool is needed to move toward patient‐specific quality assurance measurements for Ir‐192 HDR brachytherapy verify accurate dose delivery the intended location. This work describes development and use nano‐crystalline yttrium oxide inorganic scintillator based optical‐fiber detector capable acquiring real‐time high‐precision during tandem ovoid (T&O) gynecological (GYN) applicator procedures. Methods: An was calibrated by light output in...
Abstract The dosimetric advantages of proton therapy have led to its rapid proliferation in recent decades. This has been accompanied by a shift technology from older units that deliver protons passive scattering (PS) newer increasingly use pencil-beam scanning (PBS). biologic effectiveness physical dose purportedly rises with increasing dose-weighted average linear energy transfer (LET D ). objective this study was determine the extent which delivery methods affect LET . We calculated...