A5101515155- Glioma Diagnosis and Treatment
- Statistical Methods and Inference
- Advanced Neuroimaging Techniques and Applications
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Statistical Methods and Bayesian Inference
- MRI in cancer diagnosis
- Statistical Methods in Clinical Trials
- Radiation Therapy and Dosimetry
- Sarcoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Pituitary Gland Disorders and Treatments
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Optimal Experimental Design Methods
- Advanced Causal Inference Techniques
- Fetal and Pediatric Neurological Disorders
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Hemoglobinopathies and Related Disorders
- Childhood Cancer Survivors' Quality of Life
- Ocular Oncology and Treatments
- Cerebrospinal fluid and hydrocephalus
- Health Systems, Economic Evaluations, Quality of Life
St. Jude Children's Research Hospital
2016-2025
Imperial College London
2025
University of Pennsylvania
2015-2024
Oregon State University
2024
Leiden University Medical Center
2023-2024
University of Chicago
2023
Children's Hospital of Philadelphia
2019-2021
Guangxi University for Nationalities
2020
Children's National
2018
German Cancer Research Center
2018
Children with average-risk medulloblastoma (MB) experience survival rates of ≥ 80% at the expense adverse consequences treatment. Efforts to mitigate these effects include deintensification craniospinal irradiation (CSI) dose and volume.ACNS0331 (ClinicalTrials.gov identifier: NCT00085735) randomly assigned patients age 3-21 years MB receive posterior fossa radiation therapy (PFRT) or involved field (IFRT) following CSI. Young children (3-7 years) were also standard-dose CSI (SDCSI; 23.4 Gy)...
Purpose: To evaluate the feasibility and accuracy of magnetic resonance imaging (MRI)-based treatment planning using pseudo CTs generated through atlas registration. Methods: A CT, providing electron density information for dose calculation, was by deforming CT images previously acquired on other patients. The authors tested 4 schemes synthesizing a from single or multiple deformed images: use arbitrarily selected atlas, arithmetic mean process 6 atlases, pattern recognition with Gaussian...
<h3>Importance</h3> Brain tumors are the leading cause of disease-related death in children. Medulloblastoma is most common malignant embryonal brain tumor, and strategies to increase survival needed. <h3>Objective</h3> To evaluate therapy intensification with carboplatin as a radiosensitizer isotretinoin proapoptotic agent children high-risk medulloblastoma randomized clinical trial and, correlative biology study, facilitate planned subgroup analysis according World Health Organization...
Purpose Children with histologically diagnosed high-risk medulloblastoma, supratentorial primitive neuroectodermal tumor of the CNS (CNS-PNET), and pineoblastoma (PBL) have had poor survival despite intensive treatment. We included these patients in this Children’s Oncology Group trial. Molecular profiling later revealed heterogeneity that was not detectable at protocol inception. Enrollment CNS-PNET/PBL subsequently discontinued, outcomes for part study are reported here. Patients Methods...
Children treated for posterior fossa tumors experience reduced cognitive processing speed and, after imaging, show damage to white matter (WM) tracts in the brain. This study explores relationships between microstructure, assessed by fractional anisotropy (FA), and of using tract-based spatial statistics (TBSS). At 36 months treatment with radiotherapy chemotherapy, 40 patients completed an MRI examination neuropsychological evaluation. Patients were matched healthy control subjects based on...
Abstract Diffuse intrinsic pontine glioma (DIPG) is most commonly diagnosed based on imaging criteria, with biopsy often reserved for tumors features not typical DIPG (atypical DIPG, ‘aDIPG’). The histopathologic and molecular spectra of the clinical entity aDIPG remain to be studied systematically. In this study, thirty-three patients newly pontine-centered inconsistent whom a pathologic diagnosis was subsequently obtained were included. Neoplasms characterized by routine histology,...
Neuroimaging studies aim to analyze imaging data with complex spatial patterns in a large number of locations (called voxels) on two-dimensional (2D) surface or 3D volume. Conventional analyses include two sequential steps: spatially smoothing and then independently fitting statistical model at each voxel. However, conventional suffer from the same amount throughout whole image, arbitrary choice extent, low power detecting patterns. We propose multiscale adaptive regression (MARM) integrate...
The purpose of this study was to determine whether clinical and imaging features can distinguish osteomyelitis from Ewing sarcoma (EWS) assess the accuracy percutaneous biopsy versus open in diagnosis these diseases.
Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue sarcoma transformed by the pathognomonic Paired Box 3–Forkhead O1 (PAX3-FOXO1) fusion protein, which governs a core regulatory circuitry factor network. Here, we show that histone lysine demethylase 4B (KDM4B) therapeutic vulnerability for PAX3-FOXO1 + RMS. Genetic and pharmacologic inhibition of KDM4B substantially...
Importance COVID-19 in pediatric patients with acute lymphoblastic leukemia or lymphoma (ALL/LLy) has not been described detail and may affect chemotherapy administration long-term outcomes. Objective To describe the clinical presentation of modifications ALL/LLy. Design, Setting, Participants This is a retrospective case series at St Jude Children’s Research Hospital its affiliate sites newly diagnosed ALL/LLy who were treated on Total XVII protocol (NCT03117751) between March 30, 2020,...
The aim of this paper is to develop an intrinsic regression model for the analysis positive-definite matrices as responses in a Riemannian manifold and their association with set covariates, such age gender, Euclidean space. primary motivation application proposed methodology medical imaging. Because do not form vector space, directly applying classical multivariate may be inadequate establishing relationship between covariates interest, real applications. Our model, which semiparametric...
Abstract Background Our aim was to estimate long-term disease control and complications after conformal radiation therapy (CRT) in children adolescents with craniopharyngioma. Materials Methods Pediatric patients craniopharyngioma (n = 101) were enrolled on or treated according a phase II single institutional protocol from 1998. Surgery individualized, CRT (54Gy) administered using 1.0 cm 0.5 clinical target volume margin. Patients followed for 10 years by serial MR imaging angiography...
The application of deep learning techniques to the detection and automated classification Alzheimer's disease (AD) has recently gained considerable attention. rapid progress in neuroimaging sequencing enabled generation large-scale imaging genetic data for AD research. In this study, we developed a approach, IGnet, using both magnetic resonance (MRI) data. proposed approach integrates computer vision (CV) natural language processing (NLP) techniques, with three-dimensional convolutional...
Global dengue incidence has increased dramatically over the past few decades from approximately 500 000 reported cases in 2000 to 5 million 2019. This trend been attributed population growth endemic areas, rapid unplanned urbanization, increasing global connectivity, and climate change expanding geographic range of
Sickle cell disease (SCD) decreases the oxygen-carrying capacity of red blood cells. Children with SCD have reduced/restricted cerebral flow, resulting in neurocognitive deficits. Hydroxyurea is standard treatment for SCD; however, whether hydroxyurea influences such effects unclear. A key area SCD-associated impairment working memory, which implicated other cognitive and academic skills. The neural correlates memory can be tested using n-back tasks. We analyzed functional magnetic resonance...
The purpose of this study was to investigate contrast-enhanced ultrasound assessment tumor response antiangiogenic therapy in children and adolescents with solid malignancies.Children recurrent tumors who were enrolled an institutional phase 1 underwent target lesions before therapy, on days 3 7, at the end course 1. Acoustic data from lesion ROIs used measure peak enhancement, time peak, rate total AUC, AUC during wash-in (AUC1), washout (AUC2). Cox regression model assess association...
ABSTRACT Purpose To assess the level of moral distress (MD) and perceptions ethical climate among pediatric hematology/oncology (PHO) nurses to identify bioethics topics where increased education was desired. Methods In this cross‐sectional study, we administered 26‐item Swedish Moral Distress Scale‐Revised (sMDS‐R), specifically revised validated for oncology, in conjunction with Clinical Ethics Needs Assessment Survey (CENAS). Electronic surveys were sent inpatient outpatient PHO nurses....
Abstract Establishing the normative range of age‐dependent fluorodeoxyglucose (FDG) uptake in developing brain is necessary for understanding regional quantitative analysis positron emission tomography (PET) images children and also to provide functional information on development. We analyzed head sections FDG PET/computed (CT) 115 patients (5 months 23 years) without central nervous system disease before treatment, as PET studies are not performed healthy owing ethical considerations risk...