A5017417371- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Advances in Oncology and Radiotherapy
- Neonatal Health and Biochemistry
- Palliative Care and End-of-Life Issues
- Ethics and Legal Issues in Pediatric Healthcare
- Blood Pressure and Hypertension Studies
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Sodium Intake and Health
- Hedgehog Signaling Pathway Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Iron Metabolism and Disorders
- S100 Proteins and Annexins
- Healthcare cost, quality, practices
- Congenital Heart Disease Studies
- Immune cells in cancer
- Patient Safety and Medication Errors
- Maternal and Perinatal Health Interventions
- Emergency and Acute Care Studies
- Acute Ischemic Stroke Management
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Chronic Myeloid Leukemia Treatments
St. Jude Children's Research Hospital
2021-2025
Baylor College of Medicine
2016-2019
Texas Children's Hospital
2016-2019
Children's Cancer Center
2017-2018
Mayo Clinic
2017
Center for Non-Communicable Diseases
2012
University of Illinois Chicago
2012
Creative Commons
2011
Aga Khan University
2007-2011
Poor adherence is one of the biggest obstacles in therapeutic control high blood pressure. The objectives this study were (i) to measure antihypertensive therapy a representative sample hypertensive Pakistani population and (ii) investigate factors associated with studied population.A cross-sectional was conducted on simple random 460 patients at Aga Khan University Hospital (AKUH) National Institute Cardiovascular Diseases, Karachi, from September 2005-May 2006. Adherence assessed using...
PURPOSE The academic field of global pediatric oncology is expanding as cancer becomes increasingly recognized a health priority for children and adolescents. Here, we aimed to explore the representation authors, geographic distribution research, research approaches being used in oncology. METHODS Articles published JCO Global Oncology ( GO ) Pediatric Blood Cancer on topic were analyzed. For each article, data collected study design, location, authorship demographics. Descriptive...
Importance COVID-19 in pediatric patients with acute lymphoblastic leukemia or lymphoma (ALL/LLy) has not been described detail and may affect chemotherapy administration long-term outcomes. Objective To describe the clinical presentation of modifications ALL/LLy. Design, Setting, Participants This is a retrospective case series at St Jude Children’s Research Hospital its affiliate sites newly diagnosed ALL/LLy who were treated on Total XVII protocol (NCT03117751) between March 30, 2020,...
Introduction: Congenital heart disease (CHD) is associated with multiple risk factors, consanguinity may be one such significant factor. The role of in the etiology CHD supported by inbreeding studies, which demonstrate an autosomal recessive pattern inheritance some congenital defects. This study was done to find out factors for CHD. Methods: A case-control on pediatric patients at a tertiary care hospital, Aga Khan University Hospital, located Karachi, Pakistan. total 500 patients, 250...
There is currently a global shortage of healthcare professionals equipped to handle the rising burden childhood cancer. St. Jude Global an initiative improve survival rates children with cancer worldwide while improving access quality care. One overriding goals focused on education: training clinical workforce needed expand care for all Herein, we describe Academy (SJGA) and its programs. The three main workstreams SJGA are: programs, courses, distance learning. collaborates eight...
Task sharing is a pragmatic response to the growing shortage of pediatric oncologists globally, especially in low- and middle-income countries (LMICs). However, there have been limited evaluations how task has implemented. In this study, we sought determine roles responsibilities task-sharing physicians (TSPs) one LMIC, Pakistan. A multicenter cross-sectional study was conducted across 16 hospitals with secondary- quaternary-level oncology facilities. An online survey used models, TSPs,...
Abstract Neutropenia in pediatric patients can be due to a variety of disorders. We describe two who underwent extensive evaluation over many years for arthralgias and moderate neutropenia unclear etiology. Genetic testing identified pathogenic variant PSTPIP1 (proline‐serine‐threonine phosphatase‐interacting protein 1) both patients. Markedly elevated inflammatory markers zinc levels confirmed the rare diagnosis ‐associated myeloid‐related proteinemia (PAMI) syndrome, tailoring treatment....
Background There are no descriptions of stroke mechanisms from intracranial atherosclerotic disease in native South Asian Pakistanis. Methods Men and women aged ≥18 years with acute presenting to four tertiary care hospitals Karachi, Pakistan were screened using magnetic resonance angiography/transcranial Doppler scans. Trial ORG 10172 Acute Stroke Treatment criteria applied identify strokes disease. Results We studied 245 patients due Two hundred thirty scans reviewed. Also, 206/230 (89·0%)...
Conjugated hyperbilirubinemia (CHB) and liver transaminase elevation are known complications of acute lymphoblastic leukemia (ALL) therapy, but host risk factors poorly understood. Among 373 children diagnosed with ALL between 2011 2016, clinically significant CHB were observed in 15 (4.0%) 12 (3.2%) children, respectively, during induction consolidation. Body mass index ≥95th percentile (odds ratio 9.20, 95% confidence interval 2.56-32.96) was the only factor independently associated CHB,...
Abstract Juvenile myelomonocytic leukemia (JMML) has a poor prognosis in general, with hematopoietic stem cell transplant (HSCT) remaining the standard of care for cure. The hypomethylating agent, azacitidine, been used as bridging therapy to transplant. However, no patients have treated azacitidine without an HSCT post azacitidine. We report on infant JMML somatic KRAS G12A mutation and monosomy 7 who achieved sustained remission following monotherapy. He also developed aberrant...
Cardiovascular diseases (CVD) are increasing at an alarming rate in South Asia. High blood pressure is a modifiable risk factor for CVD. In this study, we evaluated the control of and prevalence cardiovascular factors patients with hypertension.A cross-sectional study was conducted 50 primary health care centres throughout Pakistan. Individuals documented history hypertension, receiving pharmacological therapy, were enrolled their pressure.The recommended therapeutic hypertension (systolic...
There are conflicting reports on whether or not laboratory abnormalities in pediatric acquired von Willebrand syndrome (AVWS) predict bleeding manifestations patients with cardiopulmonary disorders (CPD). We retrospectively reviewed charts of AVWS and CPD (n=16) seen at Texas Children's Hospital from 2003 to 2012. The most common were valve stenoses, ventricular septal defects, pulmonary hypertension. All had loss high molecular weight multimers. Fifteen (94%) presented symptoms, menorrhagia...
Background: Bereaved parents value receiving support from their children's health care teams. Pediatric residents are important members of the teams that for children at end life and can play a meaningful role in communication with bereaved families. Yet formal training expressing condolences is currently lacking. Methods: We applied Kern's six step approach to develop, implement, evaluate an innovative curriculum aimed increasing pediatric residents' comfort levels practice condolence...
Premedication with acetaminophen and/or diphenhydramine to prevent febrile nonhemolytic transfusion reactions and minor allergic is a common practice based on historical recommendations. However, recent small randomized-controlled trials showed no benefit of premedication. This inconsistency leads variability, which results in the inefficiency our institution's blood product ordering process. project aimed improve number encounters premedication plan documentation from baseline 19% 80% 12...
EPP is a rare disorder of heme biosynthesis in which patients present with disabling photosensitivity. A subset develop severe liver disease progressive failure necessitating an OLT. HCT can potentially cure by replacing the native bone marrow, primary site synthesis. However, due to concerns for inherent risks treatment-related toxicities, use has been reserved undergoing OLT avoid recurrence hepatic graft. Data are lacking, particularly pediatric population.We case 12-year-old patient...
Background: Pediatric residents lack training in expressing condolences to bereaved families after a child's death. We previously developed novel curriculum that improved residents' comfort with condolences, and now we report assessment of the longitudinal impact this on practices condolence expression. Methods: applied Kern's 6-step approach develop, implement, evaluate expression curriculum. Residents completed surveys before, immediately after, six months participating educational...