A5061639314- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Pharmacological Effects and Toxicity Studies
- Blood groups and transfusion
- Epigenetics and DNA Methylation
- Prenatal Screening and Diagnostics
- Erythrocyte Function and Pathophysiology
- Palliative Care and End-of-Life Issues
- Religion, Spirituality, and Psychology
- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Cancer-related gene regulation
- Folate and B Vitamins Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer survivorship and care
- Epilepsy research and treatment
- Cannabis and Cannabinoid Research
- Childhood Cancer Survivors' Quality of Life
- Reproductive Health and Contraception
- Pharmacogenetics and Drug Metabolism
- Pediatric Pain Management Techniques
- Acute Myeloid Leukemia Research
- Bone and Joint Diseases
- Food Security and Health in Diverse Populations
- Chronic Myeloid Leukemia Treatments
University of Illinois Chicago
2016-2025
Jesse Brown VA Medical Center
2015-2024
University of Illinois Urbana-Champaign
2009-2024
Illinois College
1985-2024
University of Illinois Hospital & Health Sciences System
2013-2022
University of Florida
2019-2022
King Saud bin Abdulaziz University for Health Sciences
2022
WiLAN (Canada)
2010-2019
National Heart Lung and Blood Institute
2019
National Institutes of Health
2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is rarely performed in adult patients with sickle disease (SCD). We utilized the chemotherapy-free, alemtuzumab/total body irradiation 300 cGy regimen sirolimus as post-transplantation immunosuppression 13 high-risk SCD between November 2011 and June 2014. Patients received matched related donor (MRD) granulocyte colony–stimulating factor–mobilized peripheral blood cells, including 2 cases that were ABO incompatible. Quality-of-life...
Background Sickle cell disease (SCD), a congenital hemolytic anemia that exacts terrible global morbidity and mortality, is driven by polymerization of mutated sickle hemoglobin (HbS) in red blood cells (RBCs). Fetal (HbF) interferes with this polymerization, but HbF epigenetically silenced from infancy onward DNA methyltransferase 1 (DNMT1). Methods findings To pharmacologically re-induce DNMT1 inhibition, first-in-human clinical trial (NCT01685515) combined 2 small molecules—decitabine to...
Summary To evaluate the association between haemoglobinuria and chronic kidney disease ( CKD ) in sickle cell anaemia SCA ), we analysed 356 adult haemoglobin SS or Sβ o thalassaemia patients from University of Illinois at Chicago UIC 439 multi‐centre Walk‐Treatment Pulmonary Hypertension Sickle Cell Disease with Sildenafil Therapy (Walk‐ PH a SST cohort. was classified according to National Kidney Foundation Outcomes Quality Initiatives guidelines. Haemoglobinuria, defined as positive haem...
Pain is the hallmark symptom of sickle cell disease (SCD), yet types pain that these patients experience, and underlying mechanisms, have not been well characterized. The study purpose was to determine safety utility a mechanical thermal quantitative sensory testing (QST) protocol feasibility utilizing neuropathic questionnaires among adults with SCD.A convenience sample (N = 25, 18 women, mean age 38.5 ± 12.5 [20-58 years]) completed self-report quality-of-life tools. Subjects also...
Sickle cell disease (SCD), an inherited blood disorder caused by a point mutation that renders hemoglobin susceptible to polymerization when deoxygenated, affects millions of people worldwide. Manifestations SCD include chronic hemolytic anemia, inflammation, painful vaso-occlusive crises, multisystem organ damage, and reduced life expectancy. Part pathophysiology is the excessive formation intracellular reactive oxygen species (ROS) in red cells (RBCs), which accelerates their hemolysis....
In the context of an inherited condition such as sickle cell disease (SCD), it is critical to understand how people with SCD or carriers (sickle trait [SCT]) face challenges making informed reproductive health decisions. The purpose this analysis was examine beliefs, attitudes, and personal feelings related Three focus groups were conducted a total 15 who had either SCT. Five themes identified: health-related issues in disease, testing for trait, partner choice, sharing status partners,...
Interactions between platelets, leukocytes, and activated endothelial cells are important during microvascular occlusion; however, the regulatory mechanisms of these heterotypic cell-cell interactions remain unclear. Here, using intravital microscopy to evaluate mice lacking specific isoforms serine/threonine kinase AKT bone marrow chimeras, we found that hematopoietic cell-associated AKT2 is for neutrophil adhesion crawling neutrophil-platelet on TNF-α-induced venular inflammation. Studies...
We report on the screening and development of haploidentical hematopoietic stem cell transplantation (HSCT) for adult patients with clinically aggressive sickle disease (SCD) at our institution. Of 50 SCD referred HSCT between January 2014 March 2017, 20% were denied by insurance. 41 initially screened, 10% lacked an available donor, 29% had elevated donor-specific antibodies (DSAs), 34% declined to proceed HSCT. All 10 who transplanted received peripheral blood cells. The initial 2...
Sickle cell disease (SCD) patients are at a four- to 100-fold increased risk for thrombosis compared with the general population, although mechanisms and factors not clear. We investigated incidence predictors in retrospective, longitudinal cohort of 1193 pediatric adult SCD treated our institution between January 2008 December 2017. diagnosis thrombotic complications were identified using International Classification Diseases coding verified through medical chart review. Clinical laboratory...
Sickle cell disease (SCD) is caused by a mutation of the β-globin gene that results in production hemoglobin S (HbS). People with SCD experience anemia, severe acute pain episodes, persistent chronic pain, multiorgan damage, and reduced life span. The pathophysiology polymerization HbS on deoxygenation red deformability generation reactive oxygen species (ROS). These 2 factors lead to fragility hemolysis. Reticulocytosis an independent predictor morbidity mortality SCD. We previously...
Pain is a frequent complaint of people living with sickle cell disease (SCD); however, the neurobiology pain in SCD remains poorly understood. Whereas this has been thought to be primarily related visceral and somatic tissue injury subsequent vaso-occlusion events, emerging evidence from human animal studies suggested that component may neuropathic processes. Significant knowledge obtained molecular neurobiological mechanisms leading maintaining pain. Some most promising implicated major...
The hallmark of sickle cell disease (SCD) is pain from a vaso-occlusive crisis. Although ambulatory accounts for most days in pain, also the common cause hospitalization and typically treated with parenteral opioids. evidence base lacking analgesic practice SCD, particularly optimal opioid dosing patient-controlled analgesia (PCA), part because challenges trial design conduct this rare disease.The purpose report to describe our Network's experiences protocol development, implementation,...
Effective quantification and in situ identification of circulating tumor cells (CTCs) blood are still elusive because the extreme rarity heterogeneity cells. In our previous studies, we developed a novel platform that captures at significantly improved efficiency vitro using unique biomimetic combination two physiological processes: E-selectin-induced cell rolling poly(amidoamine) (PAMAM) dendrimer-mediated strong multivalent binding. Herein, have engineered multifunctional surface, on basis...