A5036237741- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- FOXO transcription factor regulation
- Histone Deacetylase Inhibitors Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Neutropenia and Cancer Infections
- Multiple Myeloma Research and Treatments
- Hemoglobinopathies and Related Disorders
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- Retinoids in leukemia and cellular processes
- Signaling Pathways in Disease
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Cancer Treatment and Pharmacology
- Cutaneous lymphoproliferative disorders research
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
- HIV/AIDS drug development and treatment
- Childhood Cancer Survivors' Quality of Life
- Prenatal Screening and Diagnostics
- Synthesis and Biological Evaluation
University of Illinois Chicago
2015-2024
Northwestern University
2011-2024
AstraZeneca (United States)
2023
Indo-American Center
2023
University of Illinois Urbana-Champaign
2014-2022
Bahria University
2022
Illinois College
2019-2021
Capital University of Science and Technology
2020
University of Illinois Hospital & Health Sciences System
2014-2017
Bladder Cancer Advocacy Network
2014
Allogeneic hematopoietic stem cell transplantation (HSCT) is rarely performed in adult patients with sickle disease (SCD). We utilized the chemotherapy-free, alemtuzumab/total body irradiation 300 cGy regimen sirolimus as post-transplantation immunosuppression 13 high-risk SCD between November 2011 and June 2014. Patients received matched related donor (MRD) granulocyte colony–stimulating factor–mobilized peripheral blood cells, including 2 cases that were ABO incompatible. Quality-of-life...
Both behavioral and neuroimaging evidence support a female advantage in the perception of human faces. Here we explored possibility that this relationship may be partially mediated by sex hormones investigating between brain's response to faces use oral contraceptives, as well phase menstrual cycle. First, functional magnetic resonance images were acquired 20 young women [10 freely cycling 10 taking contraception (OC)] during two phases their cycle: mid-cycle menstruation. We found stronger...
We report on the screening and development of haploidentical hematopoietic stem cell transplantation (HSCT) for adult patients with clinically aggressive sickle disease (SCD) at our institution. Of 50 SCD referred HSCT between January 2014 March 2017, 20% were denied by insurance. 41 initially screened, 10% lacked an available donor, 29% had elevated donor-specific antibodies (DSAs), 34% declined to proceed HSCT. All 10 who transplanted received peripheral blood cells. The initial 2...
Abstract Honokiol is a natural product and an emerging drug for wide variety of malignancies, including hematopoietic sarcomas, common epithelial tumors. The broad range activity honokiol against numerous malignancies with diverse genetic backgrounds suggests that inhibiting to multiple malignancies. Oncogenic transcription factor FOXM1 one the most overexpressed oncoproteins in human cancer. Here we found inhibits FOXM1-mediated protein expression. More importantly, honokiol’s inhibitory...
Forkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly associated with therapy resistance less good patient survival. The chemotherapy options for patients the most aggressive types of solid remain very limited because acquired drug resistance, making effective. NPM1 mutation through inactivation FOXM1 via relocalization to cytoplasm confers more favorable treatment outcomes AML patients, confirming as a crucial target overcome resistance. Pharmacological...
Here we examined the addition of intensity-modulated total marrow irradiation (TMI) delivered using a linear accelerator to myeloablative chemotherapy conditioning regimen before allogeneic hematopoietic stem cell transplantation (HSCT). In this phase I study, enrolled 14 patients with high-risk hematologic malignancies who received escalating doses TMI at 3 Gy (n = 3), 6 9 6), and 12 2) in combination intravenous (i.v.) fludarabine 160 mg/m(2) targeted busulfan (area under curve, 4800...
Forkhead box protein M1 (FOXM1) is a crucial regulator of cancer development and chemoresistance. It often overexpressed in acute myeloid leukemia (AML) associated with poor survival reduced efficacy cytarabine therapy. Molecular mechanisms underlying high FOXM1 expression levels malignant cells are still unclear. Here we demonstrate that AKT constitute positive autoregulatory loop AML sustains activity both pro-oncogenic regulators. Inactivation either or signaling results disruption whole...
FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in multiple cancers. Pharmacological inhibition promising approach but has proven to be challenging. We performed network-centric transcriptomic analysis identify novel compound STL427944 that selectively suppresses by inducing the relocalization nuclear protein cytoplasm promoting its subsequent degradation autophagosomes. Human cancer cells treated with exhibit increased sensitivity cytotoxic effects...
In this phase 1 study, we tested increasing doses of total marrow irradiation (TMI) in addition to standard intravenous melphalan at 200 mg/m2 (Mel200) the conditioning regimen prior autologous stem cell transplant (ASCT) for multiple myeloma (NCT02043847). Twelve patients aged 18–75 with relapsed were enrolled study and received Mel200 TMI 3 Gy (n = 3), 6 or 9 6) transplant. There no grade 4 extra-hematologic toxicities a maximum tolerated dose was not reached. Median time neutrophil...
Acute myeloid leukemia (AML) patients with NPM1 mutations demonstrate a superior response to standard chemotherapy treatment. Our previous work has shown that these favorable outcomes are linked the cytoplasmic relocalization and inactivation of FOXM1 driven by mutated NPM1. Here, we went on confirm important role in increased chemoresistance AML. A multiinstitution retrospective study was conducted link expression clinical We establish nuclear as an independent predictor chemotherapeutic...