A5100774990- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Salivary Gland Tumors Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Clusterin in disease pathology
- Medical Imaging and Pathology Studies
- Carcinogens and Genotoxicity Assessment
- Hepatocellular Carcinoma Treatment and Prognosis
- Urological Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Metastasis and carcinoma case studies
- Urinary and Genital Oncology Studies
- Gastrointestinal Tumor Research and Treatment
- Advanced Radiotherapy Techniques
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2016-2025
St. Michael's Hospital
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2014-2024
AbbVie (United States)
2024
Guangdong Provincial Occupational Disease Prevention Hospital
2024
Southern Medical University
2022-2024
Qinghai Normal University
2024
Weatherford College
2023
Genecast (China)
2023
Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the comprehensive understanding of immune landscape tumor microenvironment (TME). Here, we obtain a detailed cell atlas esophageal squamous carcinoma (ESCC) at single-cell resolution. Exhausted T NK cells, regulatory cells (Tregs), alternatively activated macrophages tolerogenic dendritic are dominant in TME. Transcriptional profiling coupled with receptor (TCR) sequencing reveal lineage connections...
Safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) vs chemotherapy (nCT) for treatment locally advanced esophageal squamous cell carcinoma (ESCC) remain uncertain given lack high-level clinical evidence.To compare safety long-term survival nCRT followed by minimally invasive esophagectomy (MIE) with that nCT MIE patients ESCC.A prospective, multicenter, open-label, randomized trial compared ESCC. From January 1, 2017, to December 31, 2018, 264 ESCC stages from cT3 T4aN0 1M0 were...
Objective: To compare perioperative and long-term outcomes of robot-assisted minimally invasive esophagectomy (RAMIE) conventional (MIE) in the treatment for patients with esophageal squamous cell carcinoma (ESCC). Summary Background Data: RAMIE has emerged as an alternative to traditional open or thoracoscopic approaches. Efficacy safety MIE surgical ESCC remains uncertain given lack high-level clinical evidence. Methods: The trial was designed a prospective, multicenter, randomized,...
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have shown promising results. This multicenter, randomized, open-label phase 3 trial aimed to further assess the efficacy and safety of camrelizumab followed by adjuvant compared alone. A total 391 patients with thoracic LA-ESCC (T1b-3N1-3M0 or T3N0M0) were stratified clinical stage (I/II, III IVA) randomized in 1:1:1...
Objective: To determine whether RAL affects perioperative outcomes and long-term efficacy in NSCLC patients, compared with traditional VAL. Summary of Background Data: is a promising treatment for NSCLC. However, its has not been fully evaluated. Methods: A single-center, open-labeled prospective randomized clinical trial was launched May 2017 to compare the By 2020, 320 patients were enrolled. The results VAL compared. Results: enrolled randomly assigned group (n = 157) 163). Perioperative...
Abstract The family of Poly(A)-binding proteins (PABPs) regulates the stability and translation messenger RNAs (mRNAs). Here we reported that three members PABPs, including PABPC1, PABPC3 PABPC4, were identified as novel substrates for MKRN3, whose deletion or loss-of-function mutations genetically associated with human central precocious puberty (CPP). MKRN3-mediated ubiquitination was found to attenuate binding PABPs poly(A) tails mRNA, which led shortened tail-length GNRH1 mRNA...
Background Foxp3 + regulatory T (T reg ) cells facilitate tumor immune evasion by forming a suppressive microenvironment. Therefore, therapies promoting fragility may greatly enhance checkpoint blockade (ICB) efficacy in cancers. Methods We have screened 2640 compounds and identified the gut microbial metabolite gallic acid, which promotes degradation instability repressing Usp21 gene transcription. In vivo vitro experiments been performed to explore roles of cells. Importantly, we treated...
Abstract Targeting tumor-infiltrating regulatory T cells (Tregs) is an efficient way to evoke anti-tumor immune response. However, how Tregs maintain their fragility and stability remains largely unknown. IFITM3 STAT1 are interferon-induced genes that play a positive role in the progression of tumors. Here, we showed IFITM3-deficient blunted tumor growth by strengthening tumor-killing response displayed Th1-like Treg phenotype with higher secretion IFNγ. Mechanistically, depletion enhances...
LBA244 Background: Neoadjuvant chemotherapy or chemoradiotherapy followed by surgery is the standard of care for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). However, recurrence post-surgery remains a concern. Recent single-arm studies with neoadjuvant camrelizumab plus showed promising results. This multicenter, randomized, open-label, phase III study aims to evaluate role adjuvant camrelizumab, versus alone LA-ESCC. Methods: Patients thoracic LA-ESCC...
Sweet esophagectomy is performed widely in China, while the Ivor-Lewis procedure, with potential benefit of an extended lymphadenectomy, limitedly conducted owing to concern for a higher risk morbidity. Thus, role procedure thoracic esophageal cancer needs further investigation.To determine whether associated increased postoperative complications compared procedure.A randomized clinical trial was from May 2010 July 2012 at Fudan University Shanghai Cancer Center, Shanghai, 300 patients...
The objectives of this study were to evaluate the feasibility and safety robot-assisted thoracic surgery (RATS) using da Vinci robotic system for mediastinal mass resection describe surgical approach masses in different regions.We retrospectively reviewed data from 84 patients who underwent RATS a June 2015 April 2019. results analyzed with descriptive statistics.The was resected successfully all patients, one patient requiring conversion conventional open surgery. There no intraoperative...
To compare the efficacy and safety of pembrolizumab combined with neoadjuvant chemotherapy (neoCT) versus chemoradiotherapy (neoCRT) followed by surgery for locally advanced resectable oesophageal squamous cell carcinoma (ESCC).This study is a multicentre, prospective, randomized-controlled, phase III clinical study. Eligible ESCC (staging: cT1N2M0 or cT2-3N0-2M0 (stage II/III, high-risk lesions in T2N0M0)) patients will be randomly assigned to either experimental group (pembrolizumab neoCT,...
Abstract Background The aim of the study was to analyze relationship between pretreatment inflammatory biomarkers (IBs) and survival outcomes for patients with esophageal squamous cell carcinoma (ESCC) treated neoadjuvant chemoradiotherapy (neo‐CRT) pembrolizumab. Methods Clinical variables IBs (absolute monocyte count [AMC], absolute lymphocyte [ALC], platelet [PLT], neutrophil‐to‐lymphocyte ratio [NLR], platelet‐to‐lymphocyte [PLR], lymphocyte‐to‐monocyte [LMR], pan‐immune inflammation...