A5100362051- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Inflammation biomarkers and pathways
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Angiogenesis and VEGF in Cancer
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- IoT-based Smart Home Systems
- Ferroptosis and cancer prognosis
- Vascular anomalies and interventions
- Heat shock proteins research
- Sexual Differentiation and Disorders
- Meningioma and schwannoma management
- Internet of Things and Social Network Interactions
- Financial Risk and Volatility Modeling
- Cancer, Hypoxia, and Metabolism
Shanghai Chest Hospital
2015-2025
Shanghai Jiao Tong University
2015-2025
Affiliated Hospital of Guizhou Medical University
2024
Second Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Tianjin First Center Hospital
2019
Tianjin Medical University
2019
Nanchang University
2019
Air Force Medical University
2018
Defense Acquisition University
2017
Abstract Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role circRNA lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore expression profiles and mRNA 5 paired samples LUSC. By analyzing co-expression network differentially expressed circRNAs dysregulated mRNAs, identify that cycle-related circRNA, circTP63 , is upregulated LUSC tissues its upregulation correlated with larger tumor size higher TNM stage patients....
Safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) vs chemotherapy (nCT) for treatment locally advanced esophageal squamous cell carcinoma (ESCC) remain uncertain given lack high-level clinical evidence.To compare safety long-term survival nCRT followed by minimally invasive esophagectomy (MIE) with that nCT MIE patients ESCC.A prospective, multicenter, open-label, randomized trial compared ESCC. From January 1, 2017, to December 31, 2018, 264 ESCC stages from cT3 T4aN0 1M0 were...
This study is aimed at exploring the levels of peripheral blood circular RNAs (circRNAs) as biomarker candidates for diagnosis new-onset rheumatoid arthritis (RA). The selected twenty-two circRNAs in from RA patients and healthy controls (HC) were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). hsa_circ_0002715, hsa_circ_0001947, hsa_circ_0000367, hsa_circ_0035197 significantly increased than HC. And, there obvious differences above four between systemic...
Preoperative chemoradiotherapy (CRT) with CROSS regimen has been the recommended treatment for locally advanced esophageal squamous cell carcinoma (ESCC). The addition of programmed death protein 1 (PD-1) inhibitor to preoperative CRT may further improve oncologic results. camrelizumab plus chemotherapy demonstrated as a promising modality based on results phase II NICE study (ChiCTR1900026240).The NICE-2 is designed three-arm, multicenter, prospective, randomized, clinical trial, comparing...
Abstract Objectives Circular RNA, a type of RNA formed by covalently closed loop, possesses sophisticated abilities gene regulation in tumorigenesis and metastasis. However, the role circRNAs on lung adenocarcinoma (LUAD) remains largely unknown. Materials methods The cMras was examined both vitro vivo. expression LUAD tissues determined quantitative real‐time PCR (qRT‐PCR). Downstream targets were predicted bioinformatics tools confirmed immunoprecipitation assay luciferase assay. qRT‐PCR...
Epstein-Barr virus (EBV) is an oncogenic that infects more than 90% of the world's population. The proteins and miRNAs encoded by EBV are involved in multiple human malignancies. Recently R-resistance RNA-seq demonstrated EBV-encoded circular RNAs. current research aims to explore their functions EBV-associated Total 56 were sponged circRNAome. 24 9 host B epithelial cells out detectable miRNA-seq. 18 5 down-regulated both types cells, respectively, after infection. network between five...
Abstract Background After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surveillance strategy has been proposed SCC clinically (cCR) after nCRT. To justify omitting surgical resection, residual disease should be accurately identified. The aim of this study is to assess the accuracy evaluations nCRT based on preSANO trial, including positron...
443 Background: Several clinical trials have demonstrated the enhanced pathological response with addition of immune checkpoint inhibitor to neoadjuvant chemotherapy in patients resectable esophageal squamous cell carcinoma (ESCC), including phase 3 ESCORT-NEO trial. Adebrelimab, an anti-programmed death-ligand 1 antibody, has shown potential as monotherapy 1b NATION-1907 trial ESCC, a 2-year overall survival rate 92% 30 patients. This study evaluated efficacy and safety adebrelimab plus...
Abstract Background Patients with different ethnic and genetic backgrounds may respond differently to anticancer therapies. This study aimed assess whether patients oesophageal squamous cell carcinoma (OSCC) treated neoadjuvant chemoradiotherapy (nCRT) in East Asia had an inferior pathological response compared Northwest Europe. Methods OSCC who underwent nCRT according the CROSS regimen (carboplatin paclitaxel concurrent 41.4 Gy radiotherapy) followed by oesophagectomy between June 2012...
4060 Background: We conducted a phase II trial of preoperative chemotherapy with albumin paclitaxel and carboplatin combined camrelizumab (NICE regimen), in patients locally advanced esophageal squamous cell carcinoma (ESCC) multiple lymph nodes metastasis. Initial results were analyzed to assess the efficacy safety this strategy. Methods: This was prospective, multicenter, open, single arm, trial. Eligible histologically confirmed thoracic ESCC, staged as T1b-4a, N2-3 (≥ 3 stations), M0 or...
Abstract Background As a novel circRNA, BTBD7_hsa_circ_0000563 has not been fully investigated in coronary artery disease (CAD). Our aim is to reveal the possible functional role and regulatory pathway of CAD via exploring genes combined with BTBD7_hsa_circ_0000563. Methods A total 45 peripheral blood mononuclear cell (PBMC) samples patients were enrolled. The ChIRP-RNAseq assay was performed directly explore bound Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis conducted...
Background The aim of this study was to investigate the patterns and influencing factors local‐regional recurrence lower thoracic esophageal squamous cell carcinoma (TESCC) after curative resection delineate clinical target volume (CTV) postoperative radiotherapy (PORT). Methods From January 2009 December 2013, data patients who experienced esophagectomy were collected analyzed determine evaluate whether a proposed T‐shaped PORT CTV could cover regions failure. Results A total 108 eligible...
If the price of a stock differs from its intrinsic value by random noise, then stocks are more likely to have negative noise; they thus undervalued and higher expected return than justified risk. The same intuition applies small capitalization stocks. We formally verify explore this using standard noise-in-price model. This is different Jensen’s inequality effect studied Blume Stambaugh [Blume ME, RF (1983) Biases in computed returns: An application size effect. J. Financial Econom....
Our goal was to evaluate the efficacy of muscle spasm before and after rehabilitation by comparing shear wave propagation velocity (SWV) Young's modulus (YM) in normal spastic biceps brachii stroke patients.A study 60 patients with upper limb performed; these were admitted from April 2018 September 2019. The modified Ashworth scale (MAS) scores treatment compared. SWV YM on treatment, Whether are related MAS compared.There a statistically significant difference between (P < 0.01) 0.05)...
After neoadjuvant chemoradiotherapy (NCRT) in locally advanced esophageal squamous cell cancer (ESCC), roughly 40% of the patients may achieve pathologic complete response (pCR). Those benefit from organ-saving strategy if probability pCR could be correctly identified before esophagectomy. A reliable approach to predict pathological allows future studies investigate individualized treatment plans. All eligible treated our center June 2012 2019 were retrospectively collected. Radiomics...
This work aims to assess the feasibility of selectively sparing hippocampus during prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC). SCLC patients with brain metastases (BMs) diagnosed MRI were enrolled. Lesions localized neural stem (NSC) compartments [subventricular zone (SVZ) or hippocampus] analyzed. Patients categorized by total number intracranial metastases, therapy processes and symptoms. Hippocampi enhanced lesions within 15 mm from contoured. IMRT treatment...
Background: Tumors invading the depth of adventitia (T3) are most common pathological type esophageal squamous cell carcinoma (ESCC). For patients without lymph nodes metastasis, role adjuvant therapy is uncertain. This study was intended to retrospectively analyze survival effects postoperative in such patients. Methods: A total 200 with T3N0M0 (pT3N0M0) ESCC from January 2012 September 2014 were enrolled, including a surgery-alone group (Group S) 111 and surgery followed...
To develop accurate and accessible prediction methods for assessing pathologic response following NICT prior to surgery, we conducted a retrospective study including 137 patients with esophageal squamous cell carcinoma (ESCC) who underwent surgery after two cycles of between January 2019 March 2022 at our center. We collected clinical parameters evaluate the dynamic changes in primary tumor. Univariate multivariate analyses were performed determine correlations these Subsequently,...
Abstract Background Esophagectomy is still advised as an additional treatment for pathological T1b (pT1b) esophageal squamous cell carcinoma (ESCC) following attempted endoscopic resection (ER). ER followed with definitive chemoradiotherapy (dCRT) has shown increased quality of life well comparable oncological outcomes to esophagectomy. However, there no well-designed phase III trial compare the two treatments patients pT1b ESCC. Methods One hundred seventy-six clinical stage N0 (cN0) and...