A5100460913- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- GDF15 and Related Biomarkers
- MXene and MAX Phase Materials
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Tissue Engineering and Regenerative Medicine
- Renal and related cancers
- Nuclear Receptors and Signaling
- AI in cancer detection
- biodegradable polymer synthesis and properties
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Nanocluster Synthesis and Applications
- Apelin-related biomedical research
- Dyeing and Modifying Textile Fibers
- Olfactory and Sensory Function Studies
- Biopolymer Synthesis and Applications
- Genomics, phytochemicals, and oxidative stress
Second Affiliated Hospital of Nanjing Medical University
2009-2025
Jiangsu Cancer Hospital
2020-2025
Nanjing Medical University
2015-2025
Sichuan Agricultural University
2025
Yuhuangding Hospital
2025
Qingdao University
2025
Jiangsu Province Hospital
2020-2024
Tianjin Hospital
2023
Weifang Medical University
2023
Shaanxi University of Technology
2023
Abstract Circular RNAs (circRNA) are a class of covalently closed single-stranded that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated non-small cell lung (NSCLC) tissues, and negatively correlate with NSCLC malignant features. Elevated inhibits growth metastasis cells. Mechanistically, functions as scaffold enhance the interaction between TRIM25 IGF2BPs, positive regulator tumor progression metastasis. This TRIM25/circNDUFB2/IGF2BPs ternary...
Abstract Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role circRNA lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore expression profiles and mRNA 5 paired samples LUSC. By analyzing co-expression network differentially expressed circRNAs dysregulated mRNAs, identify that cycle-related circRNA, circTP63 , is upregulated LUSC tissues its upregulation correlated with larger tumor size higher TNM stage patients....
Abstract Background Emerging evidence indicates that circular RNAs (circRNAs) and m 6 A RNA methylation participate in the pathogenesis metastasis of multiple malignancies including hepatocellular carcinoma (HCC). However, it remains undocumented how circRNAs form a feedback loop with modification contributing to HCC. Methods novel hsa_circ_0017114 (circGPR137B) was identified from three pairs primary HCC adjacent normal tissues by circRNA expression profiling. The association circGPR137B...
Abstract Background Aberrant expression of circular RNAs (circRNAs) contributes to the initiation and progression human malignancies, but underlying mechanisms remain largely elusive. Methods High-throughput sequencing was performed screen aberrantly expressed circRNAs or miRNAs in colorectal cancer (CRC) adjacent normal tissues. A series gain- loss-of-function studies were conducted evaluate biological behaviors CRC cells. RNA pulldown, mass spectrometry, RIP, qRT-PCR, Western blot,...
Aberrant expression of circular RNAs (circRNAs) is involved in cancer progression through interaction with RNA-binding proteins (RBPs). Herein, we screened circRNA A549 cells circBase and the crosslinking immunoprecipitation (CLIP) data human antigen R (HuR), an extensively studied RBP, identified a circRNA, circ-defective cullin neddylation 1 domain containing 4 (circDCUN1D4), originating from DCUN1D4 gene transcript. circDCUN1D4 downregulated tumor samples under mediation DExH-box helicase...
Abstract Background Lung adenocarcinoma (LUAD) is the leading cause of death worldwide. However, roles long noncoding RNAs (lncRNAs) hijacked by super-enhancers (SEs), vital regulatory elements epigenome, remain elusive in progression LUAD metastasis. Methods SE-associated lncRNA microarrays were used to identify dysregulated lncRNAs LUAD. ChIP-seq, Hi-C data analysis, and luciferase reporter assays utilized confirm hijacking LINC01977 SE. The functions mechanisms explored a series vitro...
Accumulating studies have implicated that circular RNAs (circRNAs) play vital roles in the pathogenesis of rheumatoid arthritis (RA). Dysregulation macrophage polarization leads to immune homeostatic imbalance RA. However, altering effects and mechanisms circRNAs on macrophages balance remain largely unclear. We aimed investigate potential role circRNA_17725 The high-throughput sequence was performed identify dysregulated confirmed data by CCK-8, EdU, Annexin V/PI staining elucidate...
Abstract The present study aimed to determine whether apelin-13 could attenuate cardiac fibrosis via inhibiting the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway inhibit reactive oxygen species in heart failure (HF) rats. HF models were established by inducing ischemia myocardial infarction (MI) through ligation of left anterior descending artery Sprague–Dawley (SD) MI-induced changes hemodynamics and function reversed administration. increases levels collagen I, III,...
Abstract Background Biological role and clinical significance of circular RNAs (circRNAs) remain largely unknown. Herein, we aimed to investigate biological function, molecular mechanism, a RNA FOXM1 (circFOXM1) in non-small cell lung cancer (NSCLC). Methods Expression circFOXM1 was measured 48 paired samples NSCLC by qRT-PCR. Functional roles on tumor cells were explored vitro vivo assays. Transcriptome sequencing employed screen the molecules involved regulatory network....
Super-enhancers (SEs) are regulatory element clusters related to cell identity and disease. While the studies illustrating function of SE-associated long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD) remains few. In our research, a SE-driven lncRNA, LINC00880, was identified, which showed higher expression LUAD compared normal tissues indicated worse outcomes stage I LUADs. We found that transcription factor (TF) FOXP3 could simultaneously occupy promoter SE regions LINC00880...
Fetal growth restriction (FGR) is a worldwide problem, and major cause of perinatal morbidity. The precise molecular mechanisms involved in placental development function during FGR remain poorly understood. Circular RNAs (circRNAs) are important biological molecules associated with disease pathogenesis. However, the role circRNAs has not been well studied.circRNA expression profiles tissues without were identified by circRNA microarray. was verified quantitative reverse-transcription PCR...
Background:Abdominal aortic aneurysms (AAA) are an important cause of cardiovascular deaths. The loss vascular smooth muscle cells (VSMCs) has been reported to be related the pathology AAA. This study focused on investigating function circ_0002168 in VSMC apoptosis. Methods:Levels genes and proteins were measured by quantitative real-time-polymerase chain reaction (qRT-PCR) Western blot. growth VSMCs was determined using cell counting kit-8 assay, 5-ethynyl-2′-deoxyuridine (EdU) flow...
Classification of histological patterns in lung adenocarcinoma (LUAD) is critical for clinical decision-making, especially the early stage. However, inter- and intraobserver subjectivity pathologists make quantification varied inconsistent. Moreover, spatial information not evident to naked eye pathologists.We establish LUAD-subtype deep learning model (LSDLM) with optimal ResNet34 followed by a four-layer Neural Network classifier, based on 40 000 well-annotated path-level tiles. The LSDLM...
Abstract Background As a vital type of noncoding RNAs, circular RNAs (circRNAs) play important roles in plant growth and development stress response. However, little is known about the biological circRNAs regulating stability male fertility restoration for cytoplasmic sterility (CMS) conditioned by Gossypium harknessii cytoplasm (CMS-D2) cotton under high-temperature (HT) stress. Results In this study, RNA-sequencing bioinformatics analysis were performed on pollen grains isonuclear...
Abstract Background Circular RNAs (circRNAs) are involved in the regulation of progression and drug resistance ovarian cancer (OC). In present study, we aimed to explore role circRAD23B, a newly identified circRNA, carboplatin-resistant OC. Methods CircRAD23B expression levels were measured using qRT-PCR. The biological roles circRAD23B analysed CCK-8, colony formation, EDU, flow cytometry, cell viability assays. RNA pull-down luciferase assays used investigate interactions with mRNAs...
Abstract In recent decades, considerable evidence has emerged indicating the involvement of tRNA-derived fragments (tRFs) in cancer progression through various mechanisms. However, biological effects and mechanisms tRFs lung adenocarcinoma (LUAD) remain unclear. this study, we screen out tRF-29-79, a 5ʹ-tRF derived from tRNAGlyGCC, profiling tRF expressions three pairs LUAD tissues. We show that tRF-29-79 is downregulated downregulation associated with poorer prognosis. vivo vitro assay...
<p>5. cEMSY promotes ICD-driven anti-tumor immune surveillance.</p>
<p>Supplementary Fig. 3. cEMSY induces ICD in vitro.</p>