A5115604981- Circular RNAs in diseases
- MXene and MAX Phase Materials
- Diabetic Foot Ulcer Assessment and Management
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Bioinformatics and Genomic Networks
- interferon and immune responses
- Cardiac electrophysiology and arrhythmias
- Organ Transplantation Techniques and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reconstructive Surgery and Microvascular Techniques
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Adenosine and Purinergic Signaling
- Cardiac Arrhythmias and Treatments
- Periodontal Regeneration and Treatments
- Superconductivity in MgB2 and Alloys
- Genetic Neurodegenerative Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Immunotherapy and Immune Responses
- Systemic Sclerosis and Related Diseases
Sichuan University
2023-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
West China Hospital of Sichuan University
2023-2025
Shuguang Hospital
2025
Jiangsu Cancer Hospital
2023-2024
Affiliated Hospital of North Sichuan Medical College
2023
Chinese PLA General Hospital
2023
Zunyi Medical University
2023
Binzhou University
2016-2023
Binzhou Medical University
2016-2023
<p>5. cEMSY promotes ICD-driven anti-tumor immune surveillance.</p>
<p>Supplementary Fig. 3. cEMSY induces ICD in vitro.</p>
<div>Abstract<p>Immunogenic cell death (ICD) induces an active immune response. Activating ICD represents a potential approach to boost the antitumor activity of immunotherapy, highlighting need identify effective and safe inducers. In this study, we identified conserved, ICD-related circular RNA cEMSY by systematically screening models induced multiple stressors in lung adenocarcinoma. triggered adenocarcinoma cells both <i>in vitro</i> vivo</i>, leading...
<p>Supplementary Fig. 11. cEMSY expression level affects patient prognosis in multiple clinical cancer cohorts.</p>
<p>Supplementary Fig. 4. cEMSY knockout abrogates the ability of cellular stressors to induce ICD.</p>
<p>Supplementary Fig. 2. Characteristics of cEMSY circRNA and expression profiles in LUAD.</p>
<p>Supplementary Fig. 6. In vitro and in vivo characterization of designed circRNA.</p>
<p>Supplementary Fig. 9. mtDNA mediates the activation of ICD induced by cEMSY in vivo.</p>
<p>Supplementary Fig. 8. cEMSY activates antiviral immune signaling.</p>
<p>Supplementary Fig. 7. In vitro-transcribed cEMSY combined with anti-PD-1 promotes antitumor cure.</p>
<p>Table S1-S5</p>
<p>Supplementary Fig. 10. cEMSY modulates immune responses through facilitating the translocation of TDP-43 into mitochondria.</p>
<p>Supplementary Fig. 1. Filter ICD related circRNAs.</p>
To investigate the anti-fibrotic mechanisms of Shen Shuai II Recipe (SSR) in chronic kidney disease (CKD), focusing on its modulation hypoxia-associated inflammatory pathways and TLR4/MyD88/NF-κB/NLRP3 axis. A 5/6 nephrectomy-induced renal failure (CRF) rat model hypoxia-exposed human tubular epithelial (HK-2) cells were utilized. In vivo, function was assessed via serum creatinine, urea nitrogen, creatinine clearance measurements, alongside histopathological evaluation fibrosis...
To study the role of miR-138 on repair diabetic foot ulcer (DFU) and further to explore its possible mechanism.miR-138 inhibitor, IGF-1, LY294002 were used in DFU rat mode, mRNA expression was detected. HE staining observe histological changes skin rats. The level inflammation, wound healing, blood vessel formation-related factors detected by ELISA immunohistochemical. VEGF PI3K/AKT pathway-related proteins Western blot. determine underlying mechanism DFU, telomerase inhibitor BIBR-1232...
Abstract Immunogenic cell death (ICD) induces an active immune response. Activating ICD represents a potential approach to boost the anti-tumor activity of immunotherapy, highlighting need identify effective and safe inducers. In this study, we identified conserved, ICD-related circular RNA cEMSY by systematically screening models induced multiple stressors in lung adenocarcinoma (LUAD). triggered LUAD both vitro vivo, leading release damage-associated molecular patterns promoting T...
Abstract Background Chronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after transplantation (LTx), but effective and safe drugs are not available. Metformin exhibits high therapeutic potential due to its antifibrotic immunomodulatory effects; however, it is unclear whether metformin exerts a effect in CLAD. We sought investigate the of on CLAD based rat models. Methods Allogeneic LTx rats were treated with Cyclosporin A (CsA) first week, followed by...
Objective To investigate the methods of repair lateral skin and soft tissue defect middle rear foot with plantar medial flap transferred before achilles tendon. Methods Fifteen cases were repaired pedicled posterior tibia artery tendon from January, 2012 to October, 2015. All 15 patients followed up in way by telephone or back hospital postoperatively 3 months years, including 6 follow-up 9 back-to-hospital follow-up, observe appearance, functions whether survived...
Background: While the evidence from large-scale randomized controlled trials is conflicting, there a paucity of genetic cardiovascular adverse effects sclerostin (SOST) inhibition.Method: We performed pairwise statistical analyses to estimate pleiotropy between circulating SOST and heel bone mineral density (eBMD) as well diseases (CVDs). Additionally, we integrated genetic, transcriptional, proteomic data explore causal relationship proxied inhibition eBMD CVDs risk evaluate therapeutical...