A5083024810- Immune Response and Inflammation
- Cancer therapeutics and mechanisms
- Wound Healing and Treatments
- Advanced biosensing and bioanalysis techniques
- Electrospun Nanofibers in Biomedical Applications
- Surgical Sutures and Adhesives
- Advanced Sensor and Energy Harvesting Materials
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Mechanical and Optical Resonators
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- DNA and Nucleic Acid Chemistry
- MicroRNA in disease regulation
- Diabetic Foot Ulcer Assessment and Management
Xi'an Jiaotong University
2015-2025
Harvard University
2025
Massachusetts General Hospital
2025
Sinopec (China)
2025
China Federation of Supply and Marketing Cooperatives
2025
Fruit Research Institute
2025
National University of Singapore
2010-2024
Tianjin University of Science and Technology
2023-2024
Beijing Technology and Business University
2021-2024
Wenzhou Central Hospital
2018-2024
Abstract Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal wound dressings that can integrate matching mechanical strength, fast self‐healability, facile dressing change, and multiple therapeutic effects into one system. In this work, benefiting from catechol groups effect epigallocatechin‐3‐gallate (EGCG, green tea derivative), a smart hydrogel be conveniently obtained through copolymerization complex formed by EGCG 3‐acrylamido phenylboronic acid...
The treatment of diabetic chronic wounds remains a global challenge due to the up-regulated inflammation response, oxidant stress, and persistent infection during healing process. Developing wound dressing materials with ideal biocompatibility, adequate mechanical strength, considerable under-water adhesion, sufficient anti-inflammation, antioxidant, antibacterial properties is on-demand for clinical applications. In this study, we developed bioactive skin-mimicking hydrogel band-aid through...
Development of biocompatible hydrogel adhesives with robust tissue adhesion to realize instant hemorrhage control and injury sealing, especially for emergency rescue repair, is still challenging. Herein, we report a potent adhesive by free radical polymerization N-acryloyl aspartic acid (AASP) in facile straightforward way. Through delicate adjustment steric hindrance, the synergistic effect between interface interactions cohesion energy can be achieved PAASP verified X-ray photoelectron...
An ultradurable conductive hydrogel is designed via radical polymerization of APBA and AM in the presence XLG-stabilized CNTs. The can monitor various human motions exhibit vast potential sensing pro-healing skin wounds.
Abstract Prostate cancer (PCa) is one of the major men’s malignancies with high mortality worldwide. Circular RNAs (circRNAs) have been shown to serve as essential regulators in human cancers. CircRNA can exert their functions by cooperating host genes. In present study, microarray analysis revealed an upregulated mRNA PCa samples. X-linked inhibitor apoptosis protein (XIAP), a key regulator progression Through bioinformatics analysis, we determined that XIAP gene for circRNA0005276....
Stable mechanical properties under cyclic loads are critical for the applications of hydrogels in flexible electronics and tissue engineering. However, most existing tough still face obvious notch sensitivity suffer from fatigue fracture continuous load. Designing with multifunctional properties, such as high stretchability, toughness, excellent antifatigue fracture, through a facile strategy is on demand. In this work, nanocomposite comprehensive were prepared by one-pot polymerization...
Development of underwater adhesives with instant and robust adhesion to diverse substrates remains challenging. A strategy taking the structural advantage phenylalanine derivative, N-acryloyl (APA), is proposed facilely prepare a series polymeric glue-type (UPGAs) through one-pot radical polymerization commonly used hydrophilic vinyl monomers. The adjacent phenyl carboxyl groups in APA realize synergy between interfacial interactions cohesion strength, by which UPGAs could achieve (~5...
Abstract A superhydrophobic membrane of MnO 2 nanotube arrays on which a water droplet can be immobilized by application small DC bias, despite large contact angle, is reported. For 3 μL droplet, the measured adhesive force increases monotonically with increasing negative voltage, reaching maximum 130 μN at 22 V, 25 times original value. It follows that nearly spherical controllably pinned substrate, even if substrate turned upside down. Moreover, electrically adjustable adhesion strongly...
To investigate the anticancer effects of curcumin‑induced autophagy and its on human lung adenocarcinoma A549 cell line, inverted phase contrast microscopy was used to observe alterations cytomorphology cells. An MTT assay measure viability. Autophagy detected using acridine orange (AO) staining 3‑methyladenine (3‑MA) as an autophagy‑specific inhibitor. Dose‑ time‑dependent viability inhibition observed following curcumin treatment. A dose‑dependent increase in red fluorescent structures...
Methyl-CpG binding protein 2 (MeCP2) is involved in the carcinogenesis and progression of multiple types cancer. However, its precise role gastric cancer (GC) relevant molecular mechanism remain unknown. In present study, we found that miR-638 levels were lower GC tissues cell lines than adjacent normal epithelial lines, respectively. Low associated with poor tumor differentiation, size lymph node metastasis. MeCP2 expression higher tissues. It was inhibited proliferation, colony formation,...
Development of a physical barrier with mechanical properties similar to human smooth muscle and an on-demand degradation profile is crucial for the clinical prevention postoperative adhesion. Herein, series supramolecular hydrogels (PMI hydrogels) composed poly(ethylene glycol) (PEG), methylenediphenyl 4, 4-diisocyanate (MDI), imidazolidinyl urea (IU, hydrogen bonding reinforced factor) biodegradability high toughness are reported serve as barriers abdominal adhesion prevention. The tensile...
Fruit ripening in tomato (Solanum lycopersicum) is the result of selective expression ripening-related genes, which are regulated by transcription factors (TFs). The NAC (NAM, ATAF1/2, and CUC2) TF family one largest families plant-specific TFs members involved a variety plant physiological activities, including fruit ripening. ripening-associated studied to date include NAC-NOR (non-ripening), SlNOR-like1 (non-ripening like1), SlNAC1, SlNAC4. Considering large number genes genome, there...
Noncovalent cross-linked hydrogels with promising mechanical properties are on demand for applications in tissue engineering, flexible electronics, and actuators. However, integrating excellent facile preparation the design of hydrogen bond is still challenging. In this work, an advanced hydrogel was prepared from acrylamide N-acryloyl phenylalanine by one-pot free-radical copolymerization. Owing to hydrophobicity-assisted multiple bonding interactions among derivatives, exhibited...
Virus-induced gene silencing (VIGS) is an attractive reverse-genetics tool for studying function in plants. We showed that of a phytoene desaturase (PDS) maintained throughout TRV-PDS-inoculated tomato plants as well their flowers and fruit enhanced by low temperature (15°C) humidity (30%). RT-PCR analysis the PDS revealed dramatic reduction level mRNA leaves, fruits. Silencing results accumulation phytoene, substrate. In addition, content chlorophyll a, b total leaves PDS-silenced was...
Abstract Flagellin is a potent immunogen that activates the innate immune system via TLR5 and Naip5/6, generates strong T B cell responses. The adaptor protein MyD88 critical for signaling by TLR5, as well IL-1Rs IL-18Rs, major downstream mediators of Naip5/6 Nlrc4-inflammasome. In this study, we define roles known flagellin receptors in Ab responses generated toward flagellin. We used mice genetically deficient recognition pathways to characterize components regulate isotype-specific Using...
The mechanical stability of proteins has been extensively studied using AFM as a single-molecule force spectroscopy method. While this led to many important results, these studies have mainly limited fast unfolding at high-force regime due the rapid drift in most stretching experiments. Therefore, there is gap between knowledge obtained and properties lower which often more physiologically relevant. Recent demonstrated that can be addressed by single protein molecules magnetic tweezers,...
To investigate the underlying mechanism by which CXCL12 and CXCL6 influences metastatic potential of colon cancer internal relation stromal cells.Western blotting was used to detect expression in cells cells. The co-operative effects on proliferation invasion human umbilical vein endothelial (HUVECs) were determined enzyme-linked immunosorbent assay, assays. angiogenesis HUVECs through interaction with examined assay. We eventually investigated activation PI3K/Akt/mTOR signaling involved...
Salmonella enterica serovar Typhimurium is a flagellated bacterium and one of the leading causes gastroenteritis in humans. Bacterial flagellin required for motility also prime target innate immune system. Innate recognition mediated by at least two independent pathways, TLR5 Naip5-Naip6/NlrC4/Caspase-1. The functional significance each systems host defense against wild type infection complex, detection contributes to both protection susceptibility. We hypothesized that efficient modulation...