A5100728197- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Plant Physiology and Cultivation Studies
- Horticultural and Viticultural Research
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
- Neuropeptides and Animal Physiology
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Microplastics and Plastic Pollution
- Plant Stress Responses and Tolerance
- Effects and risks of endocrine disrupting chemicals
- Plant Reproductive Biology
- Drug-Induced Hepatotoxicity and Protection
- Colorectal Cancer Treatments and Studies
- S100 Proteins and Annexins
- Photosynthetic Processes and Mechanisms
- Liver physiology and pathology
Zhejiang University
2020-2025
First Affiliated Hospital of Zhengzhou University
2025
Dalian Medical University
2024
West China Hospital of Sichuan University
2024
Tongji Hospital
2021-2024
Huazhong University of Science and Technology
2016-2024
Fudan University
2018-2024
Shandong University
2024
Chinese Academy of Sciences
2013-2024
Sichuan University
2006-2024
Long non‐coding RNAs (lncRNAs) have been shown to important regulatory roles in cancer biology, and the lncRNA H19 is up‐regulated hypoxic stress some tumors. However, contributions of gastric remain largely unknown. In this study, we assayed expression level tissues by real‐time PCR, defined biological functions flow cytometry RNA immunoprecipitation. We demonstrated that levels were markedly increased cells compared with normal controls. Moreover, ectopic cell proliferation, whereas siRNA...
Argonaute 2 (AGO2), the core component of microRNA (miRNA)-induced silencing complex, plays a compelling role in tumorigenesis and aggressiveness. However, mechanisms regulating functions AGO2 cancer still remain elusive. Herein, we indentify one intronic circular RNA (circRNA) generated from gene (circAGO2) as novel regulator AGO2-miRNA complexes progression. CircAGO2 is up-regulated gastric cancer, colon prostate neuroblastoma, associated with poor prognosis patients. promotes growth,...
Intestinal ischemia-reperfusion (I/R) injury is a life-threatening vascular emergency and has long been disturbing problem for surgeons. Oxidative stress considered vital factor in I/R injury. Metformin anti-oxidative properties protects against The present study aimed to investigate whether intestinal reveal the protective mechanism of Metformin. was induced mice by temporary superior mesenteric artery occlusion, Caco-2 cells were subjected OGD/R establish an vitro model. Different doses...
Long non-coding RNAs (lncRNAs), a recently characterized class of RNAs, have been shown to important regulatory roles and are de-regulated in variety tumors. However, the contributions lncRNAs gastric carcinoma their functional mechanisms remain largely unknown. In this study, we found that lncRNA high expressed transcript 1 (lncRNA-GHET1) was up-regulated carcinoma. The over-expression correlates with tumor size, invasion poor survival. Gain-of-function loss-of-function analyses...
Circular RNAs (circRNAs), a subclass of non-coding RNAs, play essential roles in tumorigenesis and aggressiveness. Our previous study has identified that circAGO2 drives gastric cancer progression through activating human antigen R (HuR), protein stabilizing AU-rich element-containing mRNAs. However, the functions underlying mechanisms circRNAs derived from HuR remain elusive.CircRNAs were detected by real-time quantitative RT-PCR validated Sanger sequencing. Biotin-labeled RNA pull-down,...
Circular RNAs (circRNA), a subclass of noncoding RNA characterized by covalently closed continuous loops, play emerging roles in tumorigenesis and aggressiveness. However, the functions underlying mechanisms circRNA regulating Wnt/β-catenin signaling cancer progression remain elusive. Here, we screen cis-acting generated β-catenin (CTNNB1)/transcription factor 7-like 2 genes identify one intronic derived from CTNNB1 (circ-CTNNB1) as novel driver progression. Circ-CTNNB1 was predominantly...
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) is an example of a functional long noncoding RNA involved in many biologic processes. However, the mechanisms for Malat1 myogenesis are unclear. Serum response factor (SRF) pivotal transcription muscle proliferation and differentiation reported to be target gene muscle-specific microRNA-133 (miR-133). In this study, we initially found that silencing mouse myoblast C2C12 cell line inhibited myocyte decreased Srf at both protein...
Article11 November 2019Open Access Source DataTransparent process Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression Huanhuan Li Department Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University Science Technology, Wuhan, Hubei Province, China Search for more papers by this author Feng Yang Anpei Hu Xiaojing Wang Clinical Center Human Genomic Research, Erhu Fang Yajun Chen Pathology, Dan Huajie Song Jianqun Yanhua Guo...
As a conserved non‐coding RNA gene, transcripts of MALAT‐1 localize predominately in the nucleus. However G2/M cell cycle phase, were surprisingly found to translocate from nucleus into cytoplasm. Investigation also that this process interacts with an abundant nuclear factor, hnRNP C protein. Using loss‐of‐function assay, we down‐regulation expression compromised cytoplasmic translocation phase and resulted arrest. In addition characterize physiological interaction between C, our study...
Abstract Prostate cancer (PCa) is one of the major men’s malignancies with high mortality worldwide. Circular RNAs (circRNAs) have been shown to serve as essential regulators in human cancers. CircRNA can exert their functions by cooperating host genes. In present study, microarray analysis revealed an upregulated mRNA PCa samples. X-linked inhibitor apoptosis protein (XIAP), a key regulator progression Through bioinformatics analysis, we determined that XIAP gene for circRNA0005276....
Long noncoding RNAs (lncRNA) play essential roles in tumor progression. However, the functions of lncRNAs tumorigenesis and aggressiveness neuroblastoma still remain to be determined. Here, we report identification lncRNA pancEts-1 as a novel driver progression by using public microarray dataset. LncRNA promoted growth, invasion, metastasis cells vitro vivo Mechanistically, bound hnRNPK facilitate its physical interaction with β-catenin, whereas stabilized β-catenin inhibiting...
Acetaminophen- (APAP-) induced hepatic injury is an important clinical challenge. Oxidative stress, inflammation, apoptosis, and endoplasmic reticulum stress (ERS) contribute to the pathogenesis. Methane has potential anti-inflammatory, antioxidant, antiapoptotic properties. This project was aimed at studying protective effects relative mechanisms of methane in APAP-induced liver injury. In vivo experiment, C57BL/6 mice were treated with APAP (400 mg/kg) induce followed by methane-rich...
Abstract Background RNA pseudouridylation is a critical post‐transcriptional modification that influences gene expression and impacts various biological functions. Despite its significance, the role of mRNA in cancer remains poorly understood. This study investigates impact pseudouridine synthase 7 (PUS7)‐mediated Alpha‐ketoglutarate‐dependent Dioxygenase alkB Homolog 3 ( ALKBH3 ) gastric cancer. Methods Immunohistochemistry Western blotting were used to assess PUS7 protein levels human...
G protein-coupled receptors (GPCRs) from the secretin-like (class B) family are key players in hormonal homeostasis and important drug targets for treatment of metabolic disorders neuronal diseases. They consist a large N-terminal extracellular domain (ECD) transmembrane (TMD) with GPCR signature seven helices. Class B GPCRs activated by peptide hormones their C termini bound to receptor ECD N TMD. It is thought that functions as an affinity trap bind localize hormone receptor. This turn...
Abstract Recent evidence shows the emerging roles of promoter-targeting endogenous microRNAs (miRNAs) in regulating gene transcription. However, miRNAs affecting transcription matrix metalloproteinase 14 ( MMP-14 ) gastric cancer remain unknown. Herein, through integrative mining public datasets, we identified adjacent targeting sites Yin Yang 1 (YY1) and miRNA-584-3p (miR-584-3p) within promoter. We demonstrated that YY1 directly targeted promoter to facilitate its expression cells. In...
Aerobic glycolysis is a hallmark of metabolic reprogramming that contributes to tumor progression. However, the mechanisms regulating expression glycolytic genes in neuroblastoma (NB), most common extracranial solid childhood, still remain elusive.Crucial transcriptional regulators and their downstream were identified by integrative analysis publicly available profiling dataset. In vitro vivo assays undertaken explore biological effects underlying NB cells. Survival was performed using...
Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. Methane has been reported have anti-oxidative, anti-apoptotic and anti-inflammatory properties. We investigated the potential protective effects of methane on sepsis-induced injury determined related mechanisms. C57BL/6 mice received laparotomy with cecal ligation puncture (CLP) create septic model, followed methane-rich saline (MRS) treatment after CLP. MRS improved 5-day survival...
Abstract Background Metabolic reprogramming sustains tumorigenesis and aggressiveness of neuroblastoma (NB), the most common extracranial malignancy in childhood, while underlying mechanisms therapeutic approaches still remain elusive. Methods Circular RNAs (circRNAs) were validated by Sanger sequencing. Co-immunoprecipitation, mass spectrometry, chromatin immunoprecipitation (ChIP) sequencing, RNA sequencing assays applied to explore protein interaction target genes. Gene expression...
Sepsis is a systemic inflammatory response syndrome caused by dysregulated host to infection. Peroxisome proliferator-activated receptor gamma (PPARγ) exerts anti-inflammatory and antioxidative properties. To investigate the potential effects of PPARγ on sepsis-induced liver injury determine related mechanisms, C57BL/6 male mice were subjected cecal ligation puncture (CLP) create sepsis model which was treated with GW1929 or GW9662 upregulate downregulate expression PPARγ. We found that...
Abstract Primary cilia are antenna-like subcellular structures to act as signaling platforms regulate many cellular processes and embryonic development. m 1 A RNA modification plays key roles in metabolism gene expression; however, the physiological function of remains largely unknown. Here we find that demethylase ALKBH3 significantly inhibits ciliogenesis mammalian cells by its demethylation activity. Mechanistically, removes sites on mRNA Aurora , a master suppressor ciliogenesis....