A5101941134- Ovarian function and disorders
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Fungal Plant Pathogen Control
- Sperm and Testicular Function
- Clusterin in disease pathology
- Mast cells and histamine
- Wnt/β-catenin signaling in development and cancer
- Hypothalamic control of reproductive hormones
- Animal Diversity and Health Studies
- Mechanisms of cancer metastasis
- Systemic Sclerosis and Related Diseases
- Gynecological conditions and treatments
- TGF-β signaling in diseases
- Ion Channels and Receptors
- Coronary Interventions and Diagnostics
- Digital Imaging in Medicine
- Phytochemistry and Bioactivity Studies
- Cancer Mechanisms and Therapy
Beijing University of Chinese Medicine
2025
First Affiliated Hospital of Zhengzhou University
2013-2024
Compliant Concept
2019
Shaoyang University
2018
Sun Yat-sen Memorial Hospital
2018
Sun Yat-sen University
2018
Huazhong University of Science and Technology
1996-2017
Union Hospital
2012-2017
Tongji Hospital
2013-2016
Zhengzhou University
2014
Intraperitoneal injection of Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa) induces thymic atrophy in mice. The thymus weight, cell number, and viability began to decrease at 3 h, reached their lowest level 72 h. thymocyte death was associated with DNA fragmentation approximately 200 base pairs ladder form. kinetic study on histopathology revealed the process atrophy. Flow-cytometric analysis showed that CD4+CD8+ thymocytes decreased predominantly....
Recent evidence shows that altered microRNA-9 (miR-9) expression is implicated in the progression of gastric cancer. However, exact roles and underlying mechanisms miR-9 proliferation, invasion metastasis cancer still remain unknown. In this study, was found to be down-regulated inversely correlated with cyclin D1 v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) tissues cell lines. Bioinformatics analysis revealed putative binding sites 3′-untranslated regions (3′-UTR) Ets1 mRNA....
Abstract Recent evidence shows that v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) is implicated in tumor development and progression. However, the clinical potentials underlying mechanisms of Ets1 gastric cancer progression metastasis remain largely unknown. In this study, immunostaining was identified 56 84 (66.7%) tissues, which correlated with invasion metastasis. specimens cell lines, miRNA-145 (miR-145) downregulated inversely expression. Bioinformatics analysis luciferase...
Abstract Recent evidence shows the emerging roles of promoter-targeting endogenous microRNAs (miRNAs) in regulating gene transcription. However, miRNAs affecting transcription matrix metalloproteinase 14 ( MMP-14 ) gastric cancer remain unknown. Herein, through integrative mining public datasets, we identified adjacent targeting sites Yin Yang 1 (YY1) and miRNA-584-3p (miR-584-3p) within promoter. We demonstrated that YY1 directly targeted promoter to facilitate its expression cells. In...
Background The nature of the association between number oocytes retrieved and in vitro fertilization (IVF) outcomes after fresh embryo transfer remains unclear because conflicting results reported studies on this subject. In addition, influence quality embryos transferred is usually neglected. objective study to assess relationships retrieved, transferred, prospects pregnancy transfer. Methods data 3131 infertile women undergoing their first IVF treatment cycle January 2009 December 2010...
Introduction. In recent years, with the increase of drug resistance Candida , incidence rate and mortality candidemia have gradually increased, which has brought a huge economic health burden to people. Gap Statement. The epidemiological characteristics antifungal sensitivity patterns in different regions varied. Aim. To analyse distribution susceptibility strains isolated from bloodstreams provide basis for use drugs treatment. Methodology. A total 115 were collected bloodstream, 28...
Increasing evidence links microRNAs to the pathogenesis of peripheral vascular disease. We recently found microRNA-125b (miR-125b) be one most significantly down‑regulated in human arteries with arteriosclerosis obliterans (ASO) lower extremities. However, its function process ASO remains unclear. This study aimed investigate expression, regulatory mechanisms, and functions miR-125b ASO.Using tissue explants adherent method, smooth muscle cells (VSMCs) were prepared for this study. A rat...
A receptive endometrium is required in a successful embryo implantation. The ubiquitination-induced β-catenin degradation related to the implantation failure.This study aimed elucidate whether miR-23a-3p regulates endometrial receptivity via modulation of ubiquitination.The expressions and CUL3 were detected epithelial cells (EECs) isolated from pregnant mice hormone-induced EEC-like Ishikawa cells. ubiquitination experiment was performed explore effect on level. trophoblast attachment by...
The aim of the present study was to investigate effect propofol on immunoglobulin (Ig)E-activated mast cell degranulation and explore underlying mechanisms responsible. RBL-2H3 cells were treated with for at a variety concentrations different amounts time. Cell viability assessed using an MTT assay microRNA (miR)-221 expression quantified reverse transcription-quantitative polymerase chain reaction. transfected miR-221 mimic or negative control degranulation, including release...
To develop new anticancer agents, we prepared a sulfated polysaccharide (SCGLP1) from the fruiting bodies of Ganoderma lucidum, and effect SCGLP1 on human osteosarcoma MG63 cell line was investigated. Our result showed that treatment with resulted in significant inhibitory proliferation viability cells dose- time-dependent manner caused apoptotic death through an increase G0/G1 phase arrest, but had minor cytotoxic normal osteoblast (NHOst) cells. Western blot analysis identified...
Background Although in vitro fertilization (IVF) infertile patients with endometrial hyperplasia is common after drug treatment, the pregnancy outcomes are often unsatisfactory. Till date, no studies have reported outcome of treated using early-follicular long (EL) protocol and midluteal (ML) protocol. Objective To evaluate disease prognosis or without atypia undergoing IVF treatment EL ML Methods This was a retrospective study university-affiliated reproductive medical center. A total 138...
Of 44 representative isolates of yeast isolated from the poultry upper digestive tract 40 clinical thrush cases in Taiwan during 1985-87, 39 (89%) were classified as Candida albicans, and 5 (11%) Torulopsis pintolopesii. Fifteen commercial antifungal drugs, incorporated individually Sabouraud's dextrose agar by serial twofold dilutions, tested for their inhibitory effect against isolates. The MIC50 these drugs increasing order was less than or equal to 2 ppm GV-11, 6 gentian violet, 16...
Abstract The aim of this study was to investigate the factors predicting clinical pregnancy rate in vitro fertilization-embryo transfer (IVF-ET). data 9960 patients receiving IVF-ET fresh cycle at our Reproductive Center from January 2009 December 2017 were first divided into pregnant group and non-pregnant find rate-related factors. According serum HCG levels 36 hours 12 after trigger, all 4 groups including <50 mIU/ml, ≥50 <100 ≥100 <200 ≥200 mIU/ml know whether affect rate. ratio...
Objective This study aimed to evaluate potential predictors for recovery time in pregnant patients with moderate severe ovarian hyperstimulation syndrome (OHSS). Methods A total of 424 OHSS who underwent vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) were retrospectively identified. The clinical features and laboratory findings within 24 h after admission collected. Treatment was carried out according standard procedures, including fluid replacement therapy, human albumin,...