A5103211484- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- T-cell and Retrovirus Studies
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Cutaneous lymphoproliferative disorders research
- Gastric Cancer Management and Outcomes
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Colorectal and Anal Carcinomas
- Acute Myeloid Leukemia Research
Children's Hospital of Fudan University
2025
Guangzhou University
2025
Qilu Hospital of Shandong University
2025
First Affiliated Hospital of Zhengzhou University
2015-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
Shanxi Medical University
2024
Shanxi Academy of Medical Sciences
2024
University of Electronic Science and Technology of China
2024
Louisiana State University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Natural killer/T-cell lymphoma (NKTCL) is a rare subtype of non-Hodgkin that associated with poor outcome. Currently, the treatment needs NKTCL remain unmet, and efforts to further improve are urgently needed. Herein, seven patients who failed respond various types chemotherapies were treated anti-programmed death 1 (anti-PD-1) antibody pembrolizumab at 100 mg every 3 weeks. After median four cycles (range 2–18), out responded (two complete response, two partial overall response rate 57%)....
Abstract Purpose: Optimal treatment strategies for advanced natural killer/T (NK/T)-cell lymphoma have not been fully defined. We compared the safety and efficacy of DDGP SMILE regimens NK/T-cell in a randomized controlled, multicenter, open-label clinical trial. Experimental Design: Patients were newly diagnosed stages III–IV had performance scores 0 to 2. Six cycles (dexamethasone, cisplatin, gemcitabline, pegaspargase) or methotrexate, ifosfamide, L-asparaginase, etoposide) chemotherapy...
Abstract Background Colon cancer is a disease with high malignancy and incidence in the world. Tumor immune microenvironment (TIM) tumor mutational burden (TMB) have been proved to play crucial roles predicting clinical outcomes therapeutic efficacy, but correlation between them underlying mechanism were not completely understood colon cancer. Methods In this study, we used Single-Sample Gene Set Enrichment Analysis (ssGSEA) unsupervised consensus clustering analysis divide patients from...
<h3>Importance</h3> The L-asparaginase–based SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) chemotherapy regimen has shown higher response rates survival benefit over an anthracycline-containing regimen. However, the safety profile was not satisfied. A well-tolerated with promising efficacy is lacking. <h3>Objective</h3> To compare of DDGP cisplatin, gemcitabine, pegaspargase) in newly diagnosed advanced-stage (III/IV) extranodal natural killer/T-cell lymphoma...
Papillary thyroid cancer (PTC) is a type of malignant tumor with excellent prognosis, accounting for more than 80% cancer. Recently, numerous studies illustrated the importance N 6-methyladenosine (m6A) RNA modification to tumorigenesis, but it has never been reported in PTC. We downloaded data from The Cancer Genome Atlas (TCGA) and analyzed expression, single nucleotide polymorphisms (SNPs) copy number variations (CNVs) 19 m6A methylation regulators Then we used nonnegative matrix...
Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor outcomes. The treatment of NKTCL requires intensive chemotherapy. Long noncoding RNAs (lncRNAs) have been implicated in many cancers, including NKTCL. elucidation the multidrug resistance (MDR) may greatly contribute to explore novel therapeutic strategies. Herein, we explored roles and potential regulatory mechanism lncRNAs small nucleolar RNA host gene 12 (SNHG12) MDR We found that SNHG12 was...
Background The aim was to identify a novel prognostic miRNA signature for colon cancer (CC) in silico. Methods Data on the expression of miRNAs and relevant clinical information 407 patients were obtained from Cancer Genome Atlas (TCGA), samples randomly split into validation set (n = 203) training 204). differential between normal tissues with CC analyzed. We detected dataset by using Cox proportional hazard regression model. Then, we verified set. Association overall survival assessed...
Diffuse large B-cell lymphoma (DLBCL) is one of the leading causes cancer-related mortality, and responds badly to existing treatment. Thus, it urgent need identify novel prognostic markers therapeutic targets DLBCL. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in development cancer. By using next generation HiSeq sequencing assay, we determined lncRNAs exhibiting differential expression between DLBCL patients healthy controls. Then, RT-qPCR was...
Background: miR-155 was up-regulated in natural killer/T-cell lymphoma (NKTCL), an aggressive malignancy, and correlated with disease progression. However, minimal is known on biological activities underlying mechanisms of NKTCL. In this study, we examined BRG1, a potential target miR-155, focused the miR-155/BRG1 signaling regulating lymphangiogenesis NKTCL.Methods: The expression VEGFC, VEGFD compared between two NKTCL cell lines normal NK cells. critical role STAT3 assessed using...
Summary Purpose Apatinib, a new tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, has shown promising efficacy against several solid cancers, but evidence of its relapsed and refractory nasopharyngeal carcinoma is limited. We investigated the safety apatinib for in an open-label, single-arm, phase II clinical trial. Fifty-one patients with First Affiliated Hospital, Zhengzhou University, who met inclusion criteria were enrolled study. All received at initial...
Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive malignancy with dismal prognosis, and gaps remain in understanding the determinants influencing disease outcomes. To characterise gut microbiota feature identify potential probiotics that could ameliorate development of NKTCL. This cross-sectional study employed shotgun metagenomic sequencing to profile two Chinese NKTCL cohorts, validation conducted an independent Korean cohort. Univariable multivariable Cox proportional hazards...
To improve the understanding of lymphoma associated hemophagocytic syndrome (LAHS) and find an effective treatment for this fatal disease, 57 patients with LAHS were retrospectively reviewed. The most common histopathological type was extranodal natural killer (NK)/T-cell lymphoma, nasal (ENKL) (45.61%). Patients B-cell significantly older (P<0.001), exhibited a higher triglyceride level (P=0.012), lower serum ferritin (P=0.014) plasma Epstein-Barr virus DNA (P<0.001) compared T/NK-cell...
Abstract Background Natural Killer T–Cell Lymphoma (NKTCL) is a subtype of Non‐Hodgkin's Lymphoma, and its morbidity ranked the first T‐Cell Lymphoma. Hippo signaling pathway involved in pathogenesis tumors. However, role oncogenesis NKTCL still remains unclear. Methods The expressions mammalian sterile 20‐like kinase 1 (MST1) Yes‐associated protein (YAP) were investigated by RT‐PCR Western blotting. Cell viability was detected MTT assays. cycle cell apoptosis determined flow cytometry....
Background and aims To investigate the feasibility, safety effectiveness of ketogenic diet (KD) for super-refractory status epilepticus (SRSE) in intensive care unit (ICU). Methods We conducted a prospective investigation on patients with SRSE treated KD. The primary outcome measures were ketosis development as biomarker feasibility resolution effectiveness. KD-related side effects also investigated. Results Twelve (9 females 3 males) SRSE, median age 34 years [range 16–69, interquartile...
Background: The use of peripherally inserted central catheters (PICC) in neonates has been established for numerous years, with significant advancements and enhancements observed PICC technology over time. objective this study is to investigate the application trend a 10-year period single-center neonatal intensive care unit (NICU). Methodology: A retrospective analysis was conducted on infants admitted between January 2012 October 2021 who underwent catheterization. Data pertaining...
Alcoholic liver disease (ALD) is a major health burden linked to oxidative stress, gut dysbiosis, and disrupted hepatic metabolism. While Lactiplantibacillus plantarum ( L. ) has shown potential in alleviating ALD, the specific mechanisms bioactive components remain unclear. This study investigated hepatoprotective effects of fermentation liquid (PFL) its key metabolite, 3,4-hydroxyphenyl lactic acid (HPLA), against alcohol-induced injury. Using acute chronic alcohol intoxication mouse...
Acute myocardial infarction commonly occurs in patients with coronary artery disease, but rarely, it can develop under a hypercoagulable state. Aplastic anemia be accompanied by paroxysmal nocturnal hemoglobinuria clones or transform into significantly elevated prothrombotic These thrombotic complications predominantly arise veins rather than arteries. Coronary thrombosis these patients, especially short-term recurrent arterial after initial successful treatment, is exceedingly rare. A...