A5100604195- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Supramolecular Self-Assembly in Materials
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Immune cells in cancer
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Mycobacterium research and diagnosis
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
First Affiliated Hospital of Zhengzhou University
2016-2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Luliang University
2025
Hunan Research Academy of Environmental Sciences
2024
Changsha University of Science and Technology
2024
Shantou University
2024
Institute of Applied Ecology
2023
Chinese Academy of Sciences
2023
Henan Polytechnic University
2019-2022
Gold nanoclusters have become promising radiosensitizers due to their ultrasmall size and robust ability adsorb, scatter, re-emit radiation. However, most of the previously reported gold nanocluster do not a precise atomic structure, causing difficulties in understanding structure-activity relationship. In this study, structurally defined gold-levonorgestrel consisting Au8(C21H27O2)8 (Au8NC) with bright luminescence (58.7% quantum yield) satisfactory biocompatibility was demonstrated as...
Abstract Purpose: Optimal treatment strategies for advanced natural killer/T (NK/T)-cell lymphoma have not been fully defined. We compared the safety and efficacy of DDGP SMILE regimens NK/T-cell in a randomized controlled, multicenter, open-label clinical trial. Experimental Design: Patients were newly diagnosed stages III–IV had performance scores 0 to 2. Six cycles (dexamethasone, cisplatin, gemcitabline, pegaspargase) or methotrexate, ifosfamide, L-asparaginase, etoposide) chemotherapy...
Gadolinium (Gd)-based compounds and materials are the most commonly used magnetic resonance imaging (MRI) contrast agents in clinic; however, safety concerns associated with their toxicities free ionic form have promoted development of new generations metal-free agents. Here we report a supramolecular strategy to convert an FDA-approved anticancer drug, Pemetrexed (Pem), molecular hydrogelator inherent chemical exchange saturation transfer (CEST) MRI signals. The rationally designed...
Six1 is one of the transcription factors that act as master regulators development and are frequently dysregulated in cancers. However, role pancreatic cancer not clear. Here we show relative expression mRNA increased correlated with advanced tumor stage. In vitro functional assays demonstrate forced overexpression significantly enhances growth rate proliferation ability cells. Knockdown endogenous decreases these cells dramatically. Furthermore, promotes a xenograft assay. We also gene...
Genetic alterations drive metabolic reprograming to meet increased biosynthetic precursor and energy demands for cancer cell proliferation survival in unfavorable environments. A systematic study of gene-metabolite regulatory networks dysregulation should reveal the molecular mechanisms underlying prostate (PCa) pathogenesis. Herein, we performed gas chromatography-mass spectrometry (GC-MS)-based metabolomics RNA-seq analyses tumors matched adjacent normal tissues (ANTs) elucidate potential...
Pt-lipid coated probiotics have better resistance to the harsh environment of gastrointestinal tract, improving homeostasis intestinal epithelial barrier and offering considerable potential for treatment ulcerative colitis.
The fluorescent properties of atomically precise nanoclusters have been regulated by solvent-induced atomic structure transformation and cationic polymer-induced self-assembly for cell imaging drug delivery.
Abstract Owing to their ability rapidly proliferate in specific niches and amenability genetic manipulation, bacteria are frequently studied as potential diagnostic or therapeutic bioagents a range of pathological contexts. A sustained oxygen supply within solid tumors is essential order achieve positive radiotherapy (RT) outcomes, these intratumoral levels necessary facilitate RT‐induced reactive species (ROS) generation. In this study, genetically engineered variant the tumor‐targeting...
Long noncoding RNA (lncRNA) has been implicated in numerous tumors, including pancreatic cancer (PC). However, the precise cellular roles and molecular mechanisms of lncRNA DIO3OS on PC development remains to be fully clarified. We performed meta-analysis samples non-tumor retrieved from TCGA database, measured levels cell lines a normal duct epithelial line HPDE6-C7. Cell proliferation was evaluated via CCK-8 assay. invasion vitro investigated by transwell The immunoprecipitation assay...
Chemodynamic therapy (CDT) has been critically challenged by insufficient H2O2 in cancer tissues and inefficient reactive oxygen species (ROS) production. Herein, we have reported the facile synthesis of an efficient ROS generator (GOx@Pd@ZIF-8) that exerts synergistic anticancer activity blocking glucose metabolism producing ROS. Glucose oxidase (GOx) palladium (Pd) cube nanozymes were incorporated zeolitic imidazolate framework-8 (ZIF-8) biomimetic mineralization. Systematic...
The dysfunction of the intestinal epithelial barrier contributes to local or systemic infection and inflammation. Some lactic acid bacteria (LAB) strains had been shown improve conditions function and, for this reason, are recognized as probiotics. Weissella cibaria, a species belonging LAB group, is known promote several health benefits. However, role W. cibaria in regulating integrity has not yet investigated. In study, MW01 was isolated from Chinese sauerkraut selected based on its...