A5102772269- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Neurogenetic and Muscular Disorders Research
- Diet and metabolism studies
- Amyotrophic Lateral Sclerosis Research
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Metabolism and Genetic Disorders
- Dietary Effects on Health
- Lysosomal Storage Disorders Research
- Gastrointestinal motility and disorders
- Prostate Cancer Treatment and Research
- Nutritional Studies and Diet
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Clostridium difficile and Clostridium perfringens research
- Neurological diseases and metabolism
- Polar Research and Ecology
- Geomagnetism and Paleomagnetism Studies
- Paleontology and Stratigraphy of Fossils
- Advanced Chemical Sensor Technologies
- Geochemistry and Elemental Analysis
- Geochemistry and Geologic Mapping
Dalian Medical University
2020-2024
First Affiliated Hospital of Dalian Medical University
2020-2024
University of Cologne
2024
Chinese Academy of Sciences
2014-2020
Dalian Institute of Chemical Physics
2014-2020
University of Chinese Academy of Sciences
2017-2018
Zero to Three
2018
Prostate cancer is a highly prevalent tumor affecting millions of men worldwide, but poor understanding its pathogenesis has limited effective clinical management patients. In addition to transcriptional profiling or transcriptomics, metabolomics being increasingly utilized discover key molecular changes underlying tumorigenesis. this study, we integrated transcriptomics and analyze 25 paired human prostate tissues adjacent noncancerous tissues, followed by further validation our findings in...
Abstract Background Parkinson’s disease (PD) is a prevalent neurological in the elderly with increasing morbidity and mortality. Despite enormous efforts, rapid accurate diagnosis of PD still compromised. Metabolomics defines final readout genome-environment interactions through analysis entire metabolic profile biological matrices. Recently, unbiased profiling human sample has been initiated to identify novel biomarkers dysfunctional pathways, however, it remains challenge define reliable...
Abstract In-depth delineation of lipid metabolism in prostate cancer (PCa) is significant to open new insights into tumorigenesis and progression, provide potential biomarkers with greater accuracy for improved diagnosis. Here, we performed lipidomics transcriptomics paired tumor (PCT) adjacent nontumor (ANT) tissues, followed by external validation biomarker candidates. We identified major dysregulated pathways involving lipogenesis, uptake phospholipids remodeling, correlated widespread...
Hepatocellular carcinoma (HCC) is one of the pestilent malignancies leading to cancer-related death. Discovering effective biomarkers for HCC diagnosis an urgent demand. To identify potential metabolite biomarkers, we developed a urinary pseudotargeted method based on liquid chromatography–hybrid triple quadrupole linear ion trap mass spectrometry (LC–QTRAP MS). Compared with nontargeted method, can achieve better data quality, which benefits differential metabolites discovery. The...
Genetic alterations drive metabolic reprograming to meet increased biosynthetic precursor and energy demands for cancer cell proliferation survival in unfavorable environments. A systematic study of gene-metabolite regulatory networks dysregulation should reveal the molecular mechanisms underlying prostate (PCa) pathogenesis. Herein, we performed gas chromatography-mass spectrometry (GC-MS)-based metabolomics RNA-seq analyses tumors matched adjacent normal tissues (ANTs) elucidate potential...
The expending of elderly population worldwide has resulted in a dramatic rise the incidence chronic diseases such as Alzheimer's disease (AD). Inadequate understanding mechanisms underlying AD hampered development efficient tools for definitive diagnosis and curative interventions. Previous studies have attempted to discover reliable biomarkers AD, but these can only be measured through invasive (neuropathological markers cerebrospinal fluid) or expensive (positron emission tomography...
Despite it being the most common incident of cancer among men, pathophysiological mechanisms contributing to prostate (PCa) are still poorly understood. Altered mitochondrial metabolism is postulated play a role in development PCa. To determine key metabolites (which included oncometabolites), benign prostatic and tissues patients with PCa were analyzed using capillary electrophoresis liquid chromatography coupled mass spectrometry. Gene expression was studied real-time PCR. In tissues, we...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with progressive paralysis of limbs and bulb in patients, the cause which remains unclear. Accumulating studies suggest that motor neuron degeneration associated systemic metabolic impairment ALS. However, reprogramming underlying mechanism longitudinal progression remain poorly understood. In this study, we aimed to investigate molecular changes at both proteomic levels during identify most critical pathways mechanisms...
Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders, ameliorate autoimmune diseases, and attenuate aging. Despite efforts, mechanisms by which CR improves health, particularly brain are still not fully understood. Metabolic homeostasis vital for function, detailed metabolome atlas essential understanding networks connecting different regions. Herein, we applied gas chromatography-mass...
Speckle-type POZ protein (SPOP), as a cullin-based E3 ubiquitin ligase, has been identified one of the most frequently mutated genes in prostate cancer (PCa). However, whether SPOP mutations contribute to metabolic reprogramming PCa remains unknown. Here, integrated studies transcriptomics and metabolomics well lipidomics were performed matched tumor (PCT) adjacent non-tumor (ANT) tissues, followed by correlation analysis with altered pathways SPOP-mutated patients. Interestingly, profiling...
Abstract Iron (Fe) has profound impacts on Earth's ecosystem and global biogeochemical cycles. Fe deposited onto glacier surfaces reduces snow ice albedo, thereby accelerating melting, supplying downstream ecosystems with dissolved Fe. However, the origins of atmospheric deposition in regions western China remain unclear. This study presents novel insights into isotopic composition (refer to δ 56 Fe) origins, gained from geochemical analysis large‐scale cryoconite samples collected glaciers...
We evaluated the potential of Parkinson's disease (PD) fecal microbiota transplantation to initiate or exacerbate PD pathologies and investigated underlying mechanisms.
Abstract Hepatocellular carcinoma (HCC) is one of the pestilent malignancies leading to cancer-related death. Discovering effective biomarkers for HCC diagnosis an urgent demand. To identify potential metabolites biomarkers, we developed a urinary pseudo-targeted method based on liquid chromatography- triple quadrupole linear ion Q-trap 5500 mass spectrometry (LC-QTRAP- MS). Compared with non-targeted method, can achieve better data quality which benefits differential discovery. The...
Abstract Background Amyotrophic lateral sclerosis (ALS) is an irreversible fatal neurodegenerative disease with progressive paralysis of limbs and bulb in patients, the cause which remains unclear. Due to highly heterogeneous complex pathophysiology disease, there currently no effective treatment retard progression. Accumulating studies suggest that motor neuron degeneration associated systemic metabolic impairment ALS. However, reprogramming underlying mechanism longitudinal progression...