A5024517475- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- AI in cancer detection
- RNA modifications and cancer
- Cell Image Analysis Techniques
- Cancer-related molecular mechanisms research
- Rice Cultivation and Yield Improvement
- Plant nutrient uptake and metabolism
- Image Processing Techniques and Applications
- Gene expression and cancer classification
- MicroRNA in disease regulation
- Immune cells in cancer
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Advanced Image Processing Techniques
- Circular RNAs in diseases
- Image Retrieval and Classification Techniques
- Lung Cancer Research Studies
- BRCA gene mutations in cancer
- Congenital Diaphragmatic Hernia Studies
- Advanced Vision and Imaging
- Inflammatory Bowel Disease
- Cancer-related Molecular Pathways
- Protein Tyrosine Phosphatases
Leiden University Medical Center
2020-2025
National Institute of Biological Sciences, Beijing
2023-2025
China Agricultural University
2014-2025
Vanderbilt University Medical Center
2021-2024
Zhejiang University
2022-2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
Beijing Haidian Hospital
2024
Pennsylvania State University
2001-2024
Hunan Cancer Hospital
2022-2024
University of Chinese Academy of Sciences
2017-2024
Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is common solution for working by classifying bags of objects (i.e. sets smaller image patches). However, such processing typically performed at single scale (e.g., 20× magnification) WSIs, disregarding the vital inter-scale that key diagnoses human pathologists. In this study, we propose novel cross-scale MIL...
Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in cell and plays important roles tumorigenesis progression of multiple tumors. The present study aimed to investigate clinical significance CDC20 hepatocellular carcinoma (HCC) role HCC. By bioinformatics analysis, was found be major node HCC molecular interaction networks. Quantitative PCR western blot analyses were applied examine expression 16 paired primary...
Sequential Recommendationdescribes a set of techniques to model dynamic user behavior in order predict future interactions sequential data. At their core, such approaches transition probabilities between items sequence, whether through Markov chains, recurrent networks, or more recently, Transformers. However both old and new issues remain, including data-sparsity noisy data; can impair the performance, especially complex, parameter-hungry models. In this paper, we investigate application...
Abstract Background Aberrant expression of Aldo-Keto reductase family 1 member B10 (AKR1B10) was associated with tumor size and metastasis breast cancer in our published preliminary studies. However, little is known about the detailed function underlying molecular mechanism AKR1B10 pathological process cancer. Methods The relationship between elevated overall survival disease-free patients analyzed by Kaplan–Meier Plotter database. Breast cell lines overexpressing (MCF-7/AKR1B10) knockdown...
Crohn's disease (CD) is a complex chronic inflammatory disorder with both gastrointestinal and extra-intestinal manifestations associated immune dysregulation. Analyzing 202,359 cells from 170 specimens across 83 patients, we identify distinct epithelial cell type in terminal ileum ascending colon (hereon as 'LND') high expression of LCN2, NOS2, DUOX2 genes related to antimicrobial response immunoregulation. LND cells, confirmed by in-situ RNA protein imaging, are rare non-IBD controls but...
Unsupervised segmentation of images with low depth field (DOF) is highly useful in various applications. This paper describes a novel multiresolution image algorithm for DOF images. The designed to separate sharply focused object-of-interest from other foreground or background objects. fully automatic that all parameters are independent. A multi-scale approach based on high frequency wavelet coefficients and their statistics used perform context-dependent classification individual blocks the...
Global expression analyses using microarray technologies are becoming more common in genomic research, therefore, new statistical challenges associated with combining information from multiple studies must be addressed. In this paper we will describe our proposal for an adaptively weighted (AW) statistic to combine detecting differentially expressed genes. We also present results comparisons of proposed AW Fisher's equally (EW), Tippett's minimum p-value (minP) and Pearson's (PR) statistics....
This paper summarizes the 2nd NTIRE challenge on stereo image super-resolution (SR) with a focus new solutions and results. The task of is to super-resolve low-resolution pair high-resolution one magnification factor ×4. Compared single SR, major this lies in how exploit additional information another viewpoint maintain consistency has 3 tracks, including track distortion (e.g., PSNR) bicubic degradation, perceptual quality LPIPS) as well real degradations. In total, 175, 93, 103...
Abstract LncRNAs play pivotal roles in many important biological processes, but research on the functions of lncRNAs human disease is still its infancy. Therefore, it urgent to prioritize that are potentially associated with diseases. In this work, we developed a novel algorithm, LncPriCNet, uses multi-level composite network candidate By integrating genes, lncRNAs, phenotypes and their associations, LncPriCNet achieves an overall performance superior previous methods, high AUC values up...
Background Patients with germline/somatic BRCA1/BRCA2 mutations (g/s BRCA1/2 ) comprise a distinct biologic subgroup of pancreas ductal adenocarcinoma (PDAC). Methods Institutional databases were queried to identify patients who had PDAC g/s . Demographics, clinicopathologic details, genomic data (annotation s according precision oncology knowledge base for somatic mutations), zygosity, and outcomes abstracted. Overall survival (OS) was estimated using the Kaplan‐Meier method. Results In...
CHK1 plays a crucial role in cancer biology as it modulates cell cycle checkpoint activation and DNA repair. Furthermore, number of other cellular functions are also gradually discovered. Based on these biological functions, has been regarded potential target for therapy, but regrettably no inhibitors have marketed up to now. The incorporation effective biomarkers or combined combinations is expected promote the development process inhibitors. This paper reviews latest research progress CHK1.
The organometallic anthraquinone iridium(<sc>iii</sc>) complexes display an efficient turn-on phosphorescence response to hypoxia. can induce cell apoptosis in HeLa cells <italic>via</italic> mitochondrial dysfunction and caspase-3 activation making them excellent candidates as theranostic agents for hypoxic cancer cells.
Single-cell RNA sequencing has become a powerful tool for identifying and characterizing cellular heterogeneity. One essential step to understanding heterogeneity is determining cell identities. The widely used strategy predicts identities by projecting cells or clusters unidirectionally against reference find the best match. Here, we develop bidirectional method, scMRMA, where hierarchical guides iterative clustering deep annotation with enhanced resolutions. Taking full advantage of...
IntroductionThe programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors, atezolizumab and durvalumab, have received regulatory approval for the first-line treatment of patients with extensive-stage SCLC. Nevertheless, when used in combination platinum-based chemotherapy, these PD-L1 inhibitors only improve overall survival by 2 to 3 months. This may be due observation that less than 20% SCLC tumors express at greater 1%. Evaluating composition abundance molecules identify beyond are...
The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 genes 1,794 was analyzed. A total 111 pathogenic or likely mutations were identified, significantly higher than non-cancer individuals (111/1794 vs. 84/10,588, p < 2.2e-16). BRCA1/2 are associated with earlier onset age (median 52.5 vs 60 years-old, = 0.008). Among 29 disposition detected cohort and/or TCGA cohort, Only 11 from identified both cohorts and BRCA2...
Abstract Patients with hepatocellular carcinoma (HCC) have poor long-term survival following curative resection because of the high rate tumor early recurrence. Little is known about trajectory genomic evolution from primary to early-recurrent HCC. In this study, we performed whole-genome sequencing (WGS) on 40 pairs and hepatitis B virus (HBV)-related HCC tumors patients who received resection, four whose recurrent were extensively sampled. We identified two recurrence patterns: de novo...