A5051219890- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Protease and Inhibitor Mechanisms
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- HIV/AIDS Research and Interventions
- Blood Coagulation and Thrombosis Mechanisms
- Pulmonary Hypertension Research and Treatments
- EFL/ESL Teaching and Learning
- PARP inhibition in cancer therapy
- Syntax, Semantics, Linguistic Variation
- Colorectal Cancer Treatments and Studies
- Cervical Cancer and HPV Research
- Innovative Teaching and Learning Methods
- HIV, Drug Use, Sexual Risk
- Teacher Education and Leadership Studies
- HIV-related health complications and treatments
- Reading and Literacy Development
- Reflective Practices in Education
- Pharmaceutical Economics and Policy
- Digital literacy in education
- Multilingual Education and Policy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lung Cancer Research Studies
University of Bristol
2025
Memorial Sloan Kettering Cancer Center
1997-2025
Harvard University
2024
Davidson College
2023-2024
Kettering University
2023-2024
University Hospital Limerick
2008-2023
Alder Hey Children's NHS Foundation Trust
2023
Boston University
2016-2020
Ollscoil na Gaillimhe – University of Galway
2015-2020
Wheelock College
2020
Paclitaxel has shown significant activity in advanced ovarian cancer. In vitro studies with paclitaxel have suggested that fractionated brief infusion schedules may be more effective than the standard 24-hour infusion. We commenced a phase I evaluation of escalating-dose (40, 50, 60, 80, 100 mg/m2) administered weekly as 1-hour patients recurrent All had received prior and cisplatin therapy. premedication.Eighteen are assessable on this study. The mean age was 54 years (range, 48 to 74)....
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Human Immunodeficiency Virus (HIV) has an estimated prevalence of 0.9% in India (5.2 million). Anti-retroviral drugs (ARV) are the treatments choice and non-adherence is important factor treatment failure development resistance, as well being a powerful predictor survival. This study assesses adherence to ARV HIV positive patients Bangalore, India, country where only 10% those who need therapy receiving it. A cross-sectional anonymous questionnaire survey 60 antibody was carried out with...
Abstract The hereditary disorder α-1 antitrypsin (AAT) deficiency results from mutations in the SERPINA1 gene and presents with emphysema young adults liver disease childhood. most common form of AAT occurs because Z mutation, causing protein to fold aberrantly accumulate endoplasmic reticulum (ER). This leads ER stress contributes significantly associated condition. In addition hepatocytes, is also synthesized by monocytes, neutrophils, epithelial cells. this study we show for first time...
Alpha-1 antitrypsin deficiency (AATD) results from mutations in the SERPINA1 gene and classically presents with early-onset emphysema liver disease. The most common mutation presenting clinical evidence is Z mutation, while S associated a milder plasma deficiency. AATD an under-diagnosed condition World Health Organisation recommends targeted detection programmes for patients chronic obstructive pulmonary disease (COPD), non-responsive asthma, cryptogenic first degree relatives of known...
Triple-negative breast cancer (TNBC) is an aggressive and heterogenous subtype. RASAL2 a RAS GTPase-activating protein (GAP) that has been associated with platinum resistance in TNBC, but the underlying mechanism unknown. Here, we show enriched following neoadjuvant chemotherapy TNBC patients. This enrichment specific to tumour compartment compared adjacent normal tissues, suggesting upregulation tumour-selective. Analyses based on 2D/3D cultures patient-derived xenograft models reveal...
Background Patients with germline/somatic BRCA1/BRCA2 mutations (g/s BRCA1/2 ) comprise a distinct biologic subgroup of pancreas ductal adenocarcinoma (PDAC). Methods Institutional databases were queried to identify patients who had PDAC g/s . Demographics, clinicopathologic details, genomic data (annotation s according precision oncology knowledge base for somatic mutations), zygosity, and outcomes abstracted. Overall survival (OS) was estimated using the Kaplan‐Meier method. Results In...
Importance Microsatellite (MS) instability (MSI-H) occurs frequently in Lynch syndrome (LS)–associated tumors and is associated with response to immune checkpoint blockade (ICB) therapy. MSI-H conferred by germline or somatic variants mismatch repair genes. The contribution of oncogenesis pancreatic cancer (PC) unknown. Objective To evaluate an LS-related PC cohort define clinicogenomic features, describe cases (germline negative), characterize ICB, guide preferred MS testing methods....
Characterizing germline and somatic ATM variants (gATMm, sATMm) zygosity their contribution to homologous recombination deficiency (HRD) is important for therapeutic strategy in pancreatic ductal adenocarcinoma (PDAC).
Individuals with Alpha-1 antitrypsin deficiency (AATD) have mutations in the SERPINA1 gene causing genetic susceptibility to early onset lung and liver disease that may result premature death. Environmental interactions a significant impact determining phenotype outcome AATD. The aim of this study was assess smoke exposure on clinical AATD Ireland.Clinical demographics available thoracic computerised tomography (CT) imaging were detected from 139 PiZZ individuals identified Irish National...
4169 Background: Pancreatic adenocarcinoma (PDAC) with germline (g) or somatic (s) mutations in BRCA1/2 and PALB2 exhibit unique molecular characteristics predict response to platinum-based chemotherapy PARP inhibition. However, distinct features of PDAC are not well described. Herein, we characterize clinico-genomic patients (pts) g/s PDAC. Methods: Institutional databases cBioPortal were queried identify pts Pts variants unknown significance (VUS) excluded (annotation from OncoKb,...
4140 Background: Maintenance olaparib improves PFS in g BRCA1/2m (core HRD) mPDAC (Golan, NEJM 2019). Whether other HRD indicators, such as gene mutations than (non-Core HRD, Cohort B) and exceptional platinum responders (Cohort C, response > 6 months) may benefit from PARPi remains unanswered. We hypothesized that pembrolizumab (POLAR) combination improve outcome by immunogenic cell death. Methods: conducted an open-label, non-randomized, phase 2 trial of POLAR maintenance therapy for...
Mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most common alteration in pancreatic ductal adenocarcinoma, and KRAS glycine to cystine substitution at codon 12 (G12C) mutations (KRAS G12Cmut) are observed 1%-2%. Several inhibitors of G12C have recently demonstrated promise solid tumors, including cancer. Little known regarding clinical, genomics, outcome data this population.
4144 Background: Microsatellite instability (MSI-H) occurs in the setting of Lynch syndrome (LS), which is caused by germline pathogenic variants (gPV) mismatch repair (MMR) genes. The incidence and implications somatic MMR without LS gPV PC unknown. We present a large cohort patients (pts) with only PC, outline clinico-genomic descriptors, MSI-H prevalence, methylation status, response to ICB, comparing these features cohort. also microsatellite status (MS) orthogonal testing strategies....