Jessica Lasky‐Su
A5008569720- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
- Gut microbiota and health
- Retinal Diseases and Treatments
- Genomics and Rare Diseases
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Autism Spectrum Disorder Research
- Genetic Mapping and Diversity in Plants and Animals
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Retinal Imaging and Analysis
- Gene expression and cancer classification
- Respiratory and Cough-Related Research
- Birth, Development, and Health
- Pharmacogenetics and Drug Metabolism
- Allergic Rhinitis and Sensitization
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Philips (India)
2025
Boston Children's Hospital
2024
Harvard University Press
2009-2024
The Coordinating Center
2024
Massachusetts General Hospital
2023
Johns Hopkins University
2021-2023
Icahn School of Medicine at Mount Sinai
2023
Vision Technology (United States)
2021
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood sleep disorders, with ultimate goal improving diagnosis, treatment prevention these diseases. initial phases focused on whole-genome sequencing individuals rich phenotypic data diverse backgrounds. Here we describe TOPMed goals design as well available resources early insights obtained from sequence data. include a variant browser, genotype...
Abstract Attention deficit hyperactivity disorder (ADHD) is a complex condition with environmental and genetic etiologies. Up to this point, research has identified associations candidate genes from known biological pathways. In order identify novel ADHD susceptibility genes, 600,000 SNPs were genotyped in 958 proband‐parent trios. After applying data cleaning procedures we examined 429,981 autosomal 909 family We generated six quantitative phenotypes 18 symptoms be used genome‐wide...
The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that genomewide association study would reveal novel pharmacogenetic determinants the inhaled glucocorticoids.
Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly high-risk groups.We tested for an association between single-nucleotide polymorphisms (SNPs) gene encoding matrix metalloproteinase 12 (MMP12) a measure (prebronchodilator forced expiratory volume 1 second [FEV(1)]) more than 8300 subjects seven cohorts that included adults. Within Normative Aging Study (NAS), cohort initially...
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, genetic populations Hispanic/Latino African ancestry are limited. In addition, these more complex linkage disequilibrium structure. order better define the architecture understudied populations, we leveraged >100,000 phased sequences available from deep-coverage whole genome sequencing through multi-ethnic NHLBI Trans-Omics for Precision Medicine (TOPMed) program impute...
Summary paragraph The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, sleep disorders, with ultimate goal improving diagnosis, treatment, prevention. initial phases focus on whole genome sequencing individuals rich phenotypic data diverse backgrounds. Here, we describe TOPMed goals design as well resources early insights from sequence data. include a variant browser, genotype imputation panel, sharing...
Abstract DNA methylation clocks can accurately estimate chronological age and, to some extent, also biological age, yet the process by which age-associated (DNAm) changes are acquired appears be quasi-stochastic, raising a fundamental question: how much of an epigenetic clock’s predictive accuracy could explained stochastic DNAm change? Here, using data from sorted immune cells, we build realistic simulation models, subsequently demonstrating in over 22,770 and whole-blood samples 25...
Results of behavioral genetic and molecular studies have converged to suggest that genes substantially contribute the development attention deficit/hyperactivity disorder (ADHD), a common with an onset in childhood. Yet, despite numerous linkage candidate gene studies, strongly consistent replicable association has eluded detection. To search for ADHD susceptibility genes, we genotyped approximately 600,000 SNPs 958 affected family trios. After cleaning data, analyzed 438,784 2,803...
OBJECTIVE: Depression (major depression or depressive syndrome) is more prevalent in alcoholic than nonalcoholic subjects families with multiple members alcoholism studied as part of the Collaborative Study on Genetics Alcoholism (National Institute Alcohol Abuse and Alcoholism). First-degree relatives probands comorbid have a higher prevalence both disorders alone, groups comparison selected without regard to psychopathology. Data from collaborative study were used test three phenotypes...
Low serotonergic (5-HT) activity correlates with increased impulsive-aggressive behavior, while the opposite association may apply to cognitive impulsiveness. Both types of impulsivity are associated attention-deficit/hyperactivity disorder (ADHD), and genes functional significance for 5-HT system implicated in this disorder. Here we demonstrate separation aggressive components from symptom ratings test their functionally related using a family-based (FBAT-PC).Our sample consisted 1180...
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A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) Herbert and colleagues. The association between increased BMI homozygosity for minor allele first observed in data from a genome-wide scan 86,604 SNPs 923 related individuals Framingham Heart Study offspring cohort. reproduced four additional cohorts, but not seen fifth To further assess general reproducibility this association, we genotyped rs7566605 nine large...
Asthma is a chronic inflammatory respiratory disease that affects over 300 million people worldwide. Glucocorticoids are mainstay therapy for asthma because they exert anti-inflammatory effects in multiple lung tissues, including the airway smooth muscle (ASM). However, mechanism by which glucocorticoids suppress inflammation ASM remains poorly understood. Using RNA-Seq, high-throughput sequencing method, we characterized transcriptomic changes four primary human cell lines were treated with...
To cite this article: Hunninghake GM, Soto‐Quirós ME, Avila L, Kim HP, Lasky‐Su J, Rafaels N, Ruczinski I, Beaty TH, Mathias RA, Barnes KC, Wilk JB, O’Connor GT, James Gauderman W, Vora H, Baurley JW, Gilliland F, Liang C, Sylvia JS, Klanderman BJ, Sharma SS, Himes BE, Bossley CJ, Israel E, Raby BA, Bush A, Choi AM, Weiss ST, Celedón JC. TSLP polymorphisms are associated with asthma in a sex‐specific fashion. Allergy 2010; 65 : 1566–1575. Abstract Background: Single nucleotide (SNPs) thymic...