Hemant K. Tiwari
A5000136616- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Inflammatory mediators and NSAID effects
- Chronic Disease Management Strategies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Cardiovascular Health and Risk Factors
- Milk Quality and Mastitis in Dairy Cows
- Probiotics and Fermented Foods
- Bioinformatics and Genomic Networks
- Pulmonary Hypertension Research and Treatments
- Health Policy Implementation Science
- Metabolomics and Mass Spectrometry Studies
- Vibrio bacteria research studies
- Genetic factors in colorectal cancer
- Coccidia and coccidiosis research
- Consumer Attitudes and Food Labeling
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Rare Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Management and Research
- Identity, Memory, and Therapy
- Intraocular Surgery and Lenses
University of Alabama at Birmingham
2014-2025
Alabama Department of Public Health
2025
Sikkim University
2018
The University of Texas Health Science Center at Houston
2013
Central Agricultural University
2008
All India Institute of Medical Sciences
1982
Metabolomics is perhaps the most challenging of -omics fields, given complexity an organism's metabolome and rapid rate at which it changes. When one sets out to study metabolism there are numerous dynamic variables that can influence must be considered. Recognizing experimental challenges confronting researchers who undertake studies, workshops like University Alabama Birmingham have been established offer instructional guidance. A summary UAB course training materials being published as a...
Chronic kidney disease (CKD) impacts about 1 in 7 adults the United States, but African Americans (AAs) carry a disproportionately higher burden of disease. Epigenetic modifications, such as DNA methylation at cytosine-phosphate-guanine (CpG) sites, have been linked to function and may clinical utility predicting risk CKD. Given dynamic relationship between epigenome, environment, disease, AAs be especially sensitive environment-driven alterations. Moreover, models incorporating CpG shown...
Abstract Higher levels of moral identity, empathy, and volunteering (virtues) are associated with increased self‐esteem psychological well‐being, which, in turn, predictive fewer health problems. Epigenetic aging, a marker health, reflects the rate at which individuals age biologically relative to their chronological age. aging is shaped by behavioral factors environmental stressors, but effects on epigenetic underexplored. Thus, this study examined if these three dimensions virtue predict...
Abstract Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes 1 . By 2050, total number of patients osteoarthritis estimated to reach billion worldwide 2 As no disease-modifying treatments exist for osteoarthritis, a better understanding disease aetiopathology urgently needed. Here we perform genome-wide association study meta-analyses across up 489,975 cases 1,472,094 controls, establishing 962 independent associations,...
The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) is a hybrid of the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets, its association with renal outcomes remains unclear. In REasons Geographic Racial Disparities in Stroke (REGARDS) cohort, diet data were collected at baseline using food frequency questionnaires. Modified Poisson regression was used examine MIND incident chronic kidney disease (CKD). REGARDS stroke case-cohort, 357 metabolites...
Abstract Biological ageing estimators derived from DNA methylation (DNAm) data are heritable and correlate with morbidity mortality. Leveraging DNAm SNP >41,000 individuals, we identify 137 genome-wide significant loci (113 novel) meta-analyses of four epigenetic clocks surrogate markers for granulocyte proportions plasminogen activator inhibitor 1 levels, respectively. We report strong genetic correlations longevity lifestyle factors such as smoking, education, obesity. Significant...
Large-scale whole-genome sequencing (WGS) studies have improved our understanding of the contributions coding and noncoding rare variants to complex human traits. Leveraging association effect sizes across multiple traits in WGS variant analysis can improve statistical power over single-trait analysis, also detect pleiotropic genes regions. Existing multi-trait methods limited ability perform large-scale data. We propose MultiSTAAR, a framework computationally-scalable analytical pipeline...
Associations of HLA class II alleles with genital chlamydial infection outcomes have been reported, especially
Lipoprotein subclass concentrations are modifiable markers of cardiovascular disease risk. Fenofibrate is known to show beneficial effects on lipoprotein subclasses, but little about the role genetics in mediating responses subclasses fenofibrate. A recent genomewide association study (GWAS) associated several single nucleotide polymorphisms (SNPs) with measures, and validated these associations two independent populations. We used this information construct genetic risk scores (GRSs) for...
Background: Carbapenemase producing Enterobacteriaceae (CPE) is of great clinical concern as CPE infections are also associated with high mortality and treatment failure. Therefore, their detection becomes essential for implementation proper antimicrobial chemotherapy. Different variants New Delhi beta lactamases reported from India, however association community acquired infection not so common.In the present study we have identified NDM-5 Escherichia coli urinary tract that showing a...