A5087164434- Osteoarthritis Treatment and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Total Knee Arthroplasty Outcomes
- Musculoskeletal pain and rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Genetics, Aging, and Longevity in Model Organisms
- Birth, Development, and Health
- Knee injuries and reconstruction techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Hip disorders and treatments
- Gut microbiota and health
- Lower Extremity Biomechanics and Pathologies
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Orthopedic Infections and Treatments
- Health disparities and outcomes
- Tendon Structure and Treatment
- Diet and metabolism studies
- Genetic Mapping and Diversity in Plants and Animals
- Lipid metabolism and disorders
- Nutrition, Genetics, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammatory mediators and NSAID effects
University of North Carolina at Chapel Hill
2017-2025
University of North Carolina Health Care
2021-2024
University of North Carolina System
2023
Durham VA Medical Center
2022-2023
Emory University
2022-2023
eLearning Studios (United Kingdom)
2023
Rheumatology Consultants
2023
American College of Rheumatology
2022-2023
Duke University
2009-2016
Social Science Research Council
2015-2016
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes
Objective To examine the frequency of and factors associated with fear movement ( FOM ) among patients symptomatic knee osteoarthritis KOA ), using new Brief Fear Movement BFOM measure. Methods Participants (n = 350) enrolled in a clinical trial completed scale prior to randomization. The relationships following characteristics were examined: age, sex, race, education, pain activities daily living ADL subscales Knee Injury Osteoarthritis Outcome Score KOOS symptom duration, depressive...
To test the hypothesis that an altered gut microbiota (dysbiosis) plays a role in obesity-associated osteoarthritis (OA).
Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness humans and prominent role geriatrics gerontology. We use large samples of longitudinally followed populations from Framingham Heart Study (FHS) original offspring cohorts Long Life Family (LLFS) to investigate gender-specific effects ApoE4 allele on human survival a wide range ages midlife extreme old ages, sensitivity these cardiovascular disease (CVD), cancer, neurodegenerative...
Progress in unraveling the genetic origins of healthy aging is tempered, part, by a lack replication effects, which often considered signature false-positive findings. We convincingly demonstrate that effects on an aging-related trait can be because trade-offs gene action. focus well-studied apolipoprotein E (APOE) e2/3/4 polymorphism and lifespan ages at onset cardiovascular diseases (CVD) cancer, using data 3924 participants Framingham Heart Study Offspring cohort. Kaplan-Meier estimates...
While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging affect mortality risk. We implemented the recently developed measure of physiological dysregulation based statistical distance framework stochastic process model aging, using data blood pressure, heart rate, cholesterol, glucose, hematocrit, body mass index Framingham original cohort. This allowed...
Abstract African Americans bear a disproportionate burden of osteoarthritis (OA), but they have been underrepresented in trials behavioral interventions for pain. This trial examined culturally tailored pain coping skills training (CST) program, compared to wait list control group, among 248 with knee or hip OA. The CST program involved 11 telephone-based sessions over 3 months. Outcomes were assessed at baseline, months (primary), and 9 months, included the Western Ontario McMaster...
The inherent complexity of aging-related traits can temper progress in unraveling the genetic origins healthspan. We focus on two generations Framingham Heart Study, original (FHS) and offspring (FHSO) cohorts, to determine whether processes changing environments substantially impact role lipid-related genes discovered candidate gene (the apolipoprotein E (APOE) e2/3/4 polymorphism) genome-wide APOB rs1042034 (C/T)) studies, regulation total cholesterol (TC) onset cardiovascular disease...
Background and Objective. The influence of genes on human lifespan is mediated by biological processes that characterize body's functioning. age trajectories these contain important information about mechanisms linking aging, health lifespan. objective this paper to investigate regularities aging changes in different groups individuals, including individuals with genetic background, as well their connections Data Method. To reach we used longitudinal data four physiological variables,...
To identify patient demographic and clinical characteristics associated with osteoarthritis (OA) treatment use. This was a secondary data analysis of 3 trials among patients hip or knee OA conducted in Duke Primary Care practices, the Durham Veterans Affairs (VA) Health System, University North Carolina-Chapel Hill (UNC). At baseline, participants reported sociodemographic characteristics, OA-related pain function, use, including oral analgesics, topical creams, joint injections, physical...
To conduct an exploratory trial of a clinic-community care model (OA CARE) for managing osteoarthritis (OA). Participants (n = 60) with symptomatic knee or hip OA and overweight/obesity were randomized to CARE usual control group (UC). in the received 12-month medical membership local YMCA, which included 12-week weight loss program access exercise programming, as well referrals rehabilitation, nutrition, sleep-related psychological services. Participants' primary clinicians given...
Abstract Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes 1 . By 2050, total number of patients osteoarthritis estimated to reach billion worldwide 2 As no disease-modifying treatments exist for osteoarthritis, a better understanding disease aetiopathology urgently needed. Here we perform genome-wide association study meta-analyses across up 489,975 cases 1,472,094 controls, establishing 962 independent associations,...