A5036149017- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal pain and rehabilitation
- Inflammatory mediators and NSAID effects
- Musculoskeletal Disorders and Rehabilitation
- Knee injuries and reconstruction techniques
- Lower Extremity Biomechanics and Pathologies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Shoulder Injury and Treatment
- Spine and Intervertebral Disc Pathology
- Medical and Biological Sciences
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Orthopaedic implants and arthroplasty
- Connective tissue disorders research
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Genetic and phenotypic traits in livestock
- Tendon Structure and Treatment
- Health disparities and outcomes
- Bone and Joint Diseases
- Orthopedic Infections and Treatments
- Neurogenetic and Muscular Disorders Research
University of North Carolina at Chapel Hill
2015-2024
Faculdade São Leopoldo Mandic
2024
University of North Carolina Health Care
2015-2020
University of California Davis Medical Center
2016
Communities In Schools of Orange County
2015
Center for Rheumatology
1999-2014
Public Health Department
2014
New York Proton Center
2011
University of Tartu
2009
Johnston Memorial Hospital
2007
Abstract Objective To provide a single source for the best available estimates of US prevalence and number individuals affected by osteoarthritis, polymyalgia rheumatica giant cell arteritis, gout, fibromyalgia, carpal tunnel syndrome, as well symptoms neck back pain. A companion article (part I) addresses additional conditions. Methods The National Arthritis Data Workgroup reviewed published analyses from national surveys, such Health Nutrition Examination Survey Interview Survey. Because...
To estimate the lifetime risk of symptomatic knee osteoarthritis (OA), overall and stratified by sex, race, education, history injury, body mass index (BMI).The OA in at least 1 was estimated from logistic regression models with generalized estimating equations among 3,068 participants Johnston County Osteoarthritis Project, a longitudinal study black white women men age >or=45 years living rural North Carolina. Radiographic, sociodemographic, data measured baseline (1990-1997) first...
To report contemporary estimates of the prevalence knee-related osteoarthritis (OA) outcomes in African Americans and Caucasians aged > or = 45 years.Weighted for knee symptoms, radiographic OA, symptomatic severe OA were calculated age, ethnic, sex subgroups, 3018 participants (33% Americans, 38% men) baseline examination (1991-97) The Johnston County Osteoarthritis Project, a population-based study North Carolina. Radiographic was defined as Kellgren-Lawrence grade 2, grades 3 4, symptoms...
To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) age at diagnosis OA based on self-reports in US population.
Background: Obesity and knee osteoarthritis are among the most frequent chronic conditions affecting Americans aged 50 to 84 years. Objective: To estimate quality-adjusted life-years lost due obesity health benefits of reducing prevalence levels observed a decade ago. Design: The U.S. Census data from national sources were combined with estimated symptomatic assign persons years 4 subpopulations: nonobese without (reference group), osteoarthritis, obese osteoarthritis. Osteoarthritis Policy...
Objective To characterize serum cartilage oligomeric matrix protein (COMP) levels by age and gender for a radiographically defined population free of hip knee osteoarthritis (OA), to examine the potential utility COMP as diagnostic biomarker OA. Methods Serum samples radiographs were obtained at baseline evaluation part Johnston County Osteoarthritis Project, population-based study OA in rural North Carolina. A total 291 Caucasian participants randomly selected analysis, 143 patients with...
To perform a randomized, double-blind, crossover clinical trial of diclofenac + misoprostol versus acetaminophen in ambulatory patients with osteoarthritis the hip or knee.Patients 12 care settings were eligible if they age >40 years and had Kellgren/Lawrence radiographic grade 2-4 knee score > =30 mm on 100-mm visual analog pain scale. Patients randomized to one two groups, 75 mg 200 microg twice daily 1,000 4 times (each for 6 weeks), then crossed over other treatment weeks. A placebo was...
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In Brief Osteoarthritis (OA) places a significant burden on worldwide public health because of the large and growing number people affected by OA its associated pain disability. Pain coping skills training (PCST) is an evidence-based intervention targeting To reduce barriers that currently limit access to PCST, we developed 8-week, automated, Internet-based PCST program called PainCOACH evaluated potential efficacy acceptability in small-scale, 2-arm randomized controlled feasibility trial....
Objective Inflammatory mediators, such as prostaglandin E 2 (PGE ) and interleukin‐1β (IL‐1β), are produced by osteoarthritic (OA) joint tissue, where they may contribute to disease pathogenesis. We undertook the present study examine whether inflammation, evidenced in plasma peripheral blood leukocytes (PBLs), reflects presence, progression, or specific symptoms of symptomatic knee OA. Methods Patients with OA were enrolled a 24‐month prospective radiographic progression. Standardized...
The purpose of our study was to determine the association between biomechanical outcomes walking gait (peak vertical ground reaction force [vGRF], vGRF loading rate [vGRF-LR], and knee adduction moment [KAM]) 6 months following anterior cruciate ligament reconstruction (ACLR) biochemical markers serum type-II collagen turnover (collagen cleavage product C-propeptide [C2C:CPII]), plasma degenerative enzymes (matrix metalloproteinase-3 [MMP-3]), a pro-inflammatory cytokine (interleukin-6...
Fear of movement has important clinical implications for individuals with osteoarthritis (OA). This study aimed to establish a brief fear scale use in OA. Items from the Tampa Scale Kinesiophobia (TSK) were examined.The English version TSK was examined community-based sample (n = 1,136) OA hip or knee. Exploratory and confirmatory factor analyses used determine number content dimensions movement. Factorial invariance tested across subgroups sex, race, education, severity. Convergent validity...
Objective Symptomatic hand osteoarthritis (OA) is a common condition that affects strength and function, causes disability in activities of daily living. Prior studies have estimated the lifetime risk symptomatic knee OA 45% hip 25%. The objective present study was to estimate overall OA, stratified according potential factors. Methods Data were obtained from 2,218 adult subjects (ages ≥45 years) Johnston County Osteoarthritis Project, population‐based prospective cohort among residents...