Jakob Grove
- Autism Spectrum Disorder Research
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Attention Deficit Hyperactivity Disorder
- Birth, Development, and Health
- Genomics and Rare Diseases
- Bipolar Disorder and Treatment
- Adolescent and Pediatric Healthcare
- Prenatal Screening and Diagnostics
- Cognitive Abilities and Testing
- Eating Disorders and Behaviors
- Child Nutrition and Feeding Issues
- Child and Adolescent Psychosocial and Emotional Development
- Family and Disability Support Research
- Genetic Mapping and Diversity in Plants and Animals
- Health, Environment, Cognitive Aging
- Obsessive-Compulsive Spectrum Disorders
- Genetic Syndromes and Imprinting
- Congenital heart defects research
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Bioinformatics and Genomic Networks
Aarhus University
2016-2025
Lundbeck Foundation
2016-2025
Aarhus University Hospital
2019
Massachusetts General Hospital
2019
Integra (United States)
2019
Institute for Biomedicine
2012
deCODE Genetics (Iceland)
2012
Danish National Institute of Public Health
2009
Weatherford College
2009
National Center on Birth Defects and Developmental Disabilities
2009
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. iPSYCH2012 is nested within entire population born between 1981 2005, including 1 472 762 persons. This paper introduces outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146),...
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of school-age children and 2.5% adults. Common genetic variants contribute substantially to ADHD susceptibility, but no individual have been robustly associated with ADHD. We report genome-wide association meta-analysis 20,183 cases 35,191 controls that identifies surpassing significance in 12 independent loci, revealing new important information on the underlying biology...
<h3>Importance</h3> Anxiety and stress-related disorders are among the most common mental disorders. Although family twin studies indicate that both genetic environmental factors play an important role underlying their etiology, underpinnings of anxiety poorly understood. <h3>Objectives</h3> To estimate single-nucleotide polymorphism–based heritability disorders; to identify novel risk variants, genes, or biological pathways; test for pleiotropic associations with other psychiatric traits;...
Abstract Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural (SVs) with frequencies, termed national pan-genome, is critical for further advancing clinical public health genetics in large cohorts. Here we report Danish pan-genome obtained from sequencing 10 trios to high depth (50 × ). We 536k novel SNVs 283k short mapping approaches develop population-wide de novo assembly approach identify 132k larger than nucleotides low false discovery...