A5045364106- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Pluripotent Stem Cells Research
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Spatial Neglect and Hemispheric Dysfunction
- Hemispheric Asymmetry in Neuroscience
- Genomic variations and chromosomal abnormalities
- Alzheimer's disease research and treatments
- Diabetes and associated disorders
- CRISPR and Genetic Engineering
- Nicotinic Acetylcholine Receptors Study
- Cognitive Abilities and Testing
- Transcranial Magnetic Stimulation Studies
- Down syndrome and intellectual disability research
- Genomics and Rare Diseases
- Congenital heart defects research
- Hormonal Regulation and Hypertension
Monash University
2015-2024
Mental Health Australia
2021
Australian Regenerative Medicine Institute
2012-2019
Trinity College Dublin
2003-2013
The University of Queensland
2011-2013
University of St Andrews
2011
deCODE Genetics (Iceland)
2011
Radboud University Medical Center
2011
Medical Research Council
2011
Radboud University Nijmegen
2011
Objective: Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings suggesting that rare copy number variants (CNVs) may be important for ADHD etiology. Method: performed genome-wide analysis large, CNVs (<1% population frequency) in children with (N=896) and comparison subjects (N=2,455) from IMAGE II...
Many putative genetic factors that confer risk to neurodevelopmental disorders such as autism spectrum (ASDs) and X-linked intellectual disability (XLID), neuropsychiatric including attention deficit hyperactivity disorder (ADHD) schizophrenia (SZ) have been identified in individuals from diverse human populations. Although there is significant aetiological heterogeneity within between these conditions, recent data show contribute their comorbidity. studies candidate gene associations for...
Brain network hubs are both highly connected and inter-connected, forming a critical communication backbone for coherent neural dynamics. The mechanisms driving this organization poorly understood. Using diffusion-weighted magnetic resonance imaging in twins, we identify major role genes, showing that they preferentially influence connectivity strength between of the human connectome. transcriptomic atlas data, show demonstrate tight coupling transcriptional activity related to metabolic...
A major motivation for seeking disease-associated genetic variation is to identify novel risk processes. Although rare copy number variants (CNVs) appear contribute attention deficit hyperactivity disorder (ADHD), common (single-nucleotide polymorphisms [SNPs]) have not yet been detected using genome-wide association studies (GWAS). This raises the concern as whether future larger-scale, adequately powered GWAS will be worthwhile. The authors undertook a of ADHD and examined associated SNPs,...
BackgroundAttention-deficit/hyperactivity disorder (ADHD) shows substantial heritability and is two to seven times more common in male individuals than female individuals. We examined putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity higher burden of risk cases.MethodsWe analyzed genome-wide autosomal variants from the Psychiatric Genomics Consortium iPSYCH Project (n = 20,183 cases, n 35,191 controls) Swedish population register data 77,905 1,874,637...
A single bout of cardiovascular exercise can enhance plasticity in human cortex; however, the intensity required for optimal enhancement is debated. We investigated effect on motor cortex synaptic plasticity, using transcranial magnetic stimulation. Twenty healthy adults (Mage = 35.10 ± 13.25 years) completed three sessions. Measures cortico-motor excitability (CME) and inhibition were obtained before after a 20-min either high-intensity interval exercise, moderate-intensity continuous or...
Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at 3' end of gene. In addition, 10-repeat allele associated with ADHD has been reported be an over-active protein (DAT). Thus children possessing this variant might particularly responsive methylphenidate, drug known act by blocking DAT. We examined hypothesis and now report association between DAT1 polymorphism...
Abstract Recent family and twin study findings suggest that ADHD when comorbid with conduct problems may represent a particularly familial heritable form of ADHD. Although several independent groups have shown association between the DRD4 7 repeat allele ADHD, others failed to replicate this finding. Previous TDT analyses UK Eire samples had also been negative. We set out further examine role but selecting subgroup children problems. Families were recruited from Manchester, Ireland,...
Associations between attention deficit hyperactivity disorder (ADHD) and genetic variants within the dopamine D4 receptor gene have been much reported. Variants investigated include 7-repeat allele of a VNTR third exon, two SNPs (−521 −616) located with promoter region. We relationship VNTR, −521, −616 sustained performance in 54 ADHD probands, relative to non-genotyped control group. Participants performed Sustained Attention Response Task (SART) which response an unpredictably occurring...