A5029203077- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- BRCA gene mutations in cancer
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Cell Adhesion Molecules Research
- Advanced Proteomics Techniques and Applications
- Diet and metabolism studies
- Breast Cancer Treatment Studies
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Surgical Treatments
- Advanced Biosensing Techniques and Applications
- Organ Transplantation Techniques and Outcomes
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Molecular Biology Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Cytokine Signaling Pathways and Interactions
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
Beaumont Hospital
2014-2025
University of Medicine and Health Sciences
2024-2025
Royal College of Surgeons in Ireland
2014-2024
Harvard University
2010-2024
Inspire
2024
University College Cork
2000-2023
St. Vincent's University Hospital
2002-2022
Tallaght University Hospital
2019
Emory University
2013-2016
Mater Misericordiae University Hospital
2006-2012
OLORECTAL CANCER IS THE third most common cancer in both men and women Western countries, although incidence mortality rates are decreasing the United States. 1 Numerous studies have shown that level of spread through bowel wall adjacent lymph node involvement primary predictors long-term outcome patients with colorectal cancer. 2Other features known to be related survival include vascular perineural invasion, tumor necrosis, character invasive margin, differentiation. 3pidemiological a...
The first International AI Safety Report comprehensively synthesizes the current evidence on capabilities, risks, and safety of advanced systems. report was mandated by nations attending Summit in Bletchley, UK. Thirty nations, UN, OECD, EU each nominated a representative to report's Expert Advisory Panel. A total 100 experts contributed, representing diverse perspectives disciplines. Led Chair, these independent collectively had full discretion over content.
Activation of the noncanonical inflammasome, mediated by caspase-11, serves as an additional pathway for production proinflammatory cytokines IL-1β and IL-18. Noncanonical inflammasome activity occurs during host defense against Gram-negative bacteria in models acute septic shock. We propose that is activated mice intestinal inflammation elicited dextran sodium sulfate (DSS), a model experimental colitis. find caspase-11(-/-) display enhanced susceptibility to DSS, because impaired IL-18...
Abstract Mitogen‐activated protein kinases (MAPK) are considered to play significant roles in colonic carcinogenesis and kinase inhibitor therapy has been proposed as a potential tool the treatment of this disease. Reverse‐phase microarray assays using phospho‐specific antibodies can directly measure levels phosphorylated isoforms. In current study, samples from 35 cases untreated colorectal cancer colectomies were laser capture‐microdissected isolate epithelium stroma well normal (i.e....
To date, there is no uniform consensus on whether tumour regression grade (TRG) predictive of outcome in rectal cancer. Furthermore, the lack standardization TRG grading a major source variability published studies. The aim this study was to evaluate prognostic impact cohort patients with locally advanced cancer treated neoadjuvant chemoradiation therapy (CRT). In addition Mandard TRG, we utilized four systems modified from system and applied them assess which most informative.One-hundred...
Abstract Background Aberrant PI3K signalling is implicated in trastuzumab resistance HER2-positive gastric cancer (GC). The role of or MEK inhibitors sensitising GCs to overcoming unclear. Methods Using mass spectrometry-based genotyping we analysed 105 hotspot, non-synonymous somatic mutations PIK3CA and ERBB-family ( EGFR , ERBB2 ERBB3 ERBB4 ) genes tumour samples from 69 patients. A panel cell lines (N87, OE19, ESO26, SNU16, KATOIII) were profiled for anti-proliferative response the...
Ceramide synthase 5 is involved in the de novo synthesis of ceramide, a sphingolipid cell death and proliferation. In this study, we investigated role ceramide colorectal cancer by examining expression, clinico-pathological parameters association with survival/death signalling pathways cancer. Immunohistochemical analysis CerS5 was performed on 102 samples using tissue microarrays constructed from formalin-fixed paraffin-embedded tissues. We found strong membranous staining 57 (56%) cancers....
The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 tyrosine 3 (ERBB3) and 4 (ERBB4) gene mutations (ERBB family mutations) occur alone or co-occur with in the encoding phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) 19% of human epidermal growth factor 2 (HER2)-positive breast cancers. Because ERBB can activate PI3K/AKT pathway likely have similar canonical signalling effects to PI3K mutations, we investigated...
Compartment syndrome is a unique form of ischaemia skeletal muscle which occurs despite patency the large vessels. Decompression allows influx activated leucocytes cause further injury. Vitamin C powerful antioxidant concentrates preferentially in and attenuates reperfusion-induced We have evaluated use pretreatment with oral vitamin prevention injury caused by compartment rat cremasteric model. Acute delayed effects were assessed at one 24 hours after decompression syndrome. Muscle function...
Abstract Background Selective inhibitors of inducible cyclo-oxygenase (COX-2) are potential benefit in the perioperative period for both their analgesic and, perhaps, antineoplastic actions. However, effects on laparotomy and intestinal wound healing unknown. Methods Forty adult Sprague–Dawley rats underwent laparotomy, descending colonic transection handsewn reanastomosis. The animals were randomized to receive either a selective COX-2 inhibitor (rofecoxib, 10 mg/kg) or an equal volume...
Preoperative chemoradiotherapy is used in locally advanced rectal cancer to reduce local recurrence and improve operability, however a proportion of tumors do not undergo significant regression. Identification predictive markers response would patient selection may allow modification by targeting specific pathways. The aim this study was determine whether expression glucose transporter-1 (GLUT-1) p53 pretreatment biopsies tumor chemoradiotherapy. Immunohistochemical staining for GLUT-1...
Little is known about the origin of basal-like breast cancers, an aggressive disease that highly similar to BRCA1-mutant cancers. p63 family proteins are structurally related p53 suppressor protein function in stem cell regulation and stratified epithelia development multiple tissues, expression may be a marker Here we report ΔNp63 isoforms transcriptional targets for positive by BRCA1. Our analyses cancer tissue microarrays BRCA1-modulated lines do not support earlier reports or BRCA1...
Junctional adhesion molecule-A (JAM-A) is an molecule whose overexpression on breast tumor tissue has been associated with aggressive cancer phenotypes, including human epidermal growth factor receptor-2 (HER2)-positive disease. Since JAM-A described to regulate HER2 expression in cells, we hypothesized that JAM-dependent stabilization of could participate resistance HER2-targeted therapies. Using cell line models resistant anti-HER2 drugs, investigated and the effect silencing...
Achieving a reversible decrease of metabolism and other physiological processes in the whole organism, as occurs animals that experience torpor or hibernation, could contribute to increased survival after serious injury. Using Bayesian network tool with transcriptomic data chemical structure similarity assessments, we predicted Alzheimer's disease drug donepezil (DNP) be promising candidate for small molecule might induce torpor-like state. This was confirmed screening study Xenopus laevis...
Abstract Background Divergent estrogen receptor (ER) and HER2 status with breast cancer disease progression has important consequences for clinical management long-term survival. Molecular subtype expression is dynamic influenced by therapeutic intervention the metastatic environment. There remains however, a lack of data regarding mechanism switching subsequent consequences. Methods We undertook study neoadjuvant inhibitor treated patients (n=161) to determine consequence treatment...
Abstract This study investigated whether measures of three perceived control (PC) concepts tapped independent dimensions, were invariant to population characteristics health and culture, differentially sensitive outcomes, discriminable from self-report disability. The Multidimensional Health Locus Control, Generalized Self-efficacy, Perceived Competence (PHC) Scales administered 106 Scottish students 145 Scottish, Spanish Irish patients, who also completed versions the Sickness Impact...
Abstract Background and Aim TRIM 28 is a multi‐domain nuclear protein with pleotropic effects in both normal tumor cells. In this study, expression epithelial stromal microenvironment its prognostic role colorectal cancer were investigated. Methods Immunohistological staining of was evaluated tissue microarrays constructed from 137 patients. The correlations clinicopathological features p53 studied. K aplan– M eier analysis C ox proportional hazard modeling used to assess overall survival (...