A5028428278- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Mental Health and Psychiatry
- Genetic Associations and Epidemiology
- Children's Physical and Motor Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Hedgehog Signaling Pathway Studies
- Cognitive Abilities and Testing
- Liver Disease Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Dental Health and Care Utilization
- Microtubule and mitosis dynamics
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Zoonotic diseases and public health
Peking University
2016-2025
Peking University Sixth Hospital
2016-2025
Gansu University of Traditional Chinese Medicine
2025
Shanghai Customs College
2024
National Clinical Research
2015-2024
University of Calgary
2013-2023
Northeast Agricultural University
2017-2023
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
General Hospital of Shenyang Military Region
2022-2023
Objective: Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings suggesting that rare copy number variants (CNVs) may be important for ADHD etiology. Method: performed genome-wide analysis large, CNVs (<1% population frequency) in children with (N=896) and comparison subjects (N=2,455) from IMAGE II...
In studies describing the long-term follow-up up of youth at clinical high risk (CHR) psychosis, little attention has been given to details specific prodromal symptoms. this paper, we describe symptoms 764 CHR participants recruited in multi-site North American Prodrome Longitudinal Study (NAPLS). Symptoms were rated on Scale Prodromal (SOPS) baseline and 6-, 12-, 18-, 24-month follow-ups. Clinical outcome 2-year assessment was categorized as psychotic, progression, symptomatic or remission....
Abstract Attention‐deficit hyperactivity disorder (ADHD) is a complex polygenic disorder. This study aimed to discover common and rare DNA variants associated with ADHD in large homogeneous Han Chinese case–control sample. The sample comprised 1,040 cases 963 controls. All met DSM‐IV diagnostic criteria. We used the Affymetrix6.0 array assay both single nucleotide polymorphisms (SNPs) copy number (CNVs). Genome‐wide association analyses were performed using PLINK. SNP‐heritability...
In the literature, there have been several attempts to develop prediction models for youth who are at clinical high risk (CHR) of developing psychosis. Although no specific or demographic variables that seem consistently predict later transition psychosis in those CHR youth, addition attenuated psychotic symptoms, most commonly occuring predictors tend be poor social functioning and certain cognitive tasks. Unfortunately, has little attempt replicate alogorithms. A recently published article...
Much of the interest in youth at clinical high risk (CHR) psychosis has been understanding conversion. Recent literature suggested that less than 25% those who meet established criteria for being CHR go on to develop a psychotic illness. However, little is known about outcome do not make transition psychosis. The aim this paper was examine symptoms and functioning second North American Prodrome Longitudinal Study (NAPLS 2) individuals whose by end 2 years study had developed psychosis.In...
Using three European and two Chinese genome-wide association studies (GWAS), we investigated the performance of genetic risk scores (GRSs) for predicting susceptibility severity systemic lupus erythematosus (SLE), using renal disease as a proxy severity. We used four GWASs to test GRS both cross validating within population between populations. The in SLE prediction was evaluated by receiver operating characteristic (ROC) curves. then analyzed polygenic nature statistically. also partitioned...
Objectives Trichomoniasis one of the most neglected sexually transmitted diseases (STDs), imposes a significant global disease burden. This study aims to assess burden and trends trichomoniasis from 1990 2021 project its incidence 2022 2050. Methods utilized data Global Burden Disease for secondary analysis. We determined age-standardized rate (ASIR) disability-adjusted life years (DALYs) by sex, age, socio-demographic index (SDI) level. Changes in across sex age were explored 2021, using...
Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death. China has the largest population of patients with traumatic injury. Previous studies in have mostly been regional scope; national-level rare. To best our knowledge, no study treatment status economic burden performed. This retrospective aimed examine epidemiological clinical features, status, at national level. We included 13,465 who were injured between January 2013 December 2018...
Maladaptive memories elicited by exposure to environmental stimuli associated with drugs of abuse are often responsible for relapse among addicts. Interference the reconsolidation drug memory can inhibit seeking. Previous studies have indicated that dephosphorylation eukaryotic initiation factor 2 α-subunit (eIF2α) plays an important role in synaptic plasticity and long-term consolidation, but its remains unknown. The amygdala is required a destabilized after retrieval drug-paired stimuli....
Social cognition, the mental operations that underlie social interactions, is a major construct to investigate in schizophrenia. Impairments cognition are present before onset of psychosis, and even unaffected first-degree relatives, suggesting may be trait marker illness. In large cohort individuals at clinical high risk for psychosis (CHR) healthy controls, three domains (theory mind, facial emotion recognition perception) were assessed clarify which impaired this population. Six-hundred...
Executive function (EF) deficits are major impairments in adults with attention deficit/hyperactivity disorder (ADHD). Previous studies have shown that the insula is involved cognitive and EFs. However, highly heterogeneous function, few focused on functional networks which related to specific insular subregions ADHD. We explored of [anterior (AI), mid-insula (MI), posterior (PI)]. Furthermore, their correlations self-ratings ecological EFs, including inhibition, shifting, working memory...
Berberine (BBR), the major isoquinoline alkaloid in Chinese herb Rhizoma coptidis, has significant lipid-lowering effect by upregulating hepatic low-density lipoprotein receptor (LDLR) expression. In a previous study, we have indicated that berberrubine (M3), metabolite of BBR vivo, displays most potential hypolipidemic effects via LDLR expression human hepatoma (HepG2) cells compared with and 3 other metabolites. Accordingly, 9 M3 analogs (A1-A9) were modified at C9 position. We aimed to...
Abstract Attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood, with a shift of symptoms including less hyperactivity/impulsivity and more co-morbidity affective disorders in ADHD adult . Many studies have questioned the stability diagnosing from childhood to shared distinct aberrant functional connectivities (FCs) between child remain unidentified. We aim explore FC patterns , further investigated cross-cohort predictability using identified FCs. After investigating...