A5081945380- Spinal Cord Injury Research
- Nerve injury and regeneration
- Spine and Intervertebral Disc Pathology
- Neurogenesis and neuroplasticity mechanisms
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Mesenchymal stem cell research
- Musculoskeletal pain and rehabilitation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Nerve Injury and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Medical Imaging and Analysis
- Extracellular vesicles in disease
- Spinal Dysraphism and Malformations
- Cancer-related molecular mechanisms research
- Medical Research and Treatments
- Spinal Hematomas and Complications
- Anesthesia and Pain Management
- Bone Metabolism and Diseases
- Sports injuries and prevention
- Bone health and osteoporosis research
- Pelvic and Acetabular Injuries
- Tissue Engineering and Regenerative Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
Tianjin Medical University General Hospital
2016-2025
Qilu Hospital of Shandong University
2021-2025
China International Science and Technology Cooperation
2018-2025
Shandong University
2021-2025
Second Hospital of Shandong University
2023-2025
Guizhou University
2025
Tianjin Municipal Engineering Design and Research Institute
2024
Zhejiang University of Technology
2023
Advanced Medical Research Institute
2022-2023
Barro Colorado Island
2023
Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It yet be clarified whether inhibition represents the mechanism of action Deferoxamine on recovery. A rat model at thoracic 10 segment was established using modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in group intraperitoneally injected with 100 mg/kg 30 minutes before injury. Simultaneously, Sham and...
Spinal cord injury (SCI) is one of the most debilitating injuries, and transplantation stem cells in a scaffold promising strategy for treatment. However, cell treatment SCI has been severely impaired by increased generation reactive oxygen species lesion microenvironment, which can lead to high level death dysfunction. Herein, MnO2 nanoparticle (NP)-dotted hydrogel prepared through dispersion NPs PPFLMLLKGSTR peptide modified hyaluronic acid hydrogel. The peptide-modified enables adhesive...
<h3>Objectives</h3> In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression. <h3>Methods</h3> Destabilisation medial meniscus (DMM) surgery was performed in 10-week-old wild type AMP-activated protein kinase (AMPK)α1 knockout (KO) mice. Metformin (4 mg/day drinking water) given, commencing either 2 weeks before or after DMM surgery. Mice were sacrificed 6 12 OA phenotype analysed by micro-computerised tomography (μCT), histology...
Objectives To evaluate the most up-to-date burden of traumatic brain injury (TBI) and spinal cord (SCI) analyse their leading causes in different countries/territories. Design An analysis Global Burden Disease (GBD) data. Setting The epidemiological data were gathered from GBD Results Tool (1 January, 1990─31 December 2019) covering 21 regions 204 countries/ territories. Participants Patients with TBI/SCI. Main outcomes measures Absolute numbers age-standardised rates/estimates incidence,...
Revascularization treatment is a critical measure for tissue engineering therapies like spinal cord repair. As multipotent stem cells, mesenchymal cells (MSCs) have proven to regulate the lesion microenvironment through feedback signals. The angiogenic capacities of MSCs been reported be facilitated by vein endothelial in niche. emerging evidence demonstrated roles exosomes cell-cell and cell-microenvironment communications, cope with ischemia complication traumatic injury, study extracts...
Abstract Macrophage/microglia polarization acts as an important part in regulating inflammatory responses spinal cord injury (SCI). However, the regulation of inflammation Schwann cell-derived exosomes (SCDEs) for SCI repair is still unclear. Therefore, we intend to find out effect SCDEs on related macrophage during recovery SCI. Firstly, thesis demonstrated that could attenuate LPS- BMDMs by suppressing M1 and stimulating M2 polarization. Similarly, improved functional female Wistar rats...
Abstract Spinal cord injury (SCI) is a refractory neurological disorder. Due to the complex pathological processes, especially secondary inflammatory cascade and lack of intrinsic regenerative capacity, it difficult recover function after SCI. Meanwhile, simulating conductive microenvironment spinal reconstructs electrical neural signal transmission interrupted by SCI facilitates repair. Therefore, double‐crosslinked hydrogel (BP@Hydrogel) containing black phosphorus nanoplates (BP)...
Abstract Peripheral nerve injuries represent one of the most common causes permanent disabilities. Therapeutic electrical stimulation has been widely used in neural regeneration for decades. Combined with implantation a cuff, several outcomes have proven effectiveness and feasibility neuroprosthetic applications. However, current strategy fails to complete repair. There is lack research on long‐term implantable nanogenerators neurostimulation scenario. Especially considering many disease...
Spinal cord injury (SCI) can cause permanent loss of sensory and motor function, there is no effective clinical treatment, to date. Due the complex pathological process involved after injury, synergistic treatments are very urgently needed in practice. We designed a nanofiber scaffold hyaluronic acid hydrogel patch release both exosomes methylprednisolone injured spinal non-invasive manner. This composite showed good biocompatibility stabilization exosome morphology toxicity nerve cells....
Abstract Neural stem cells (NSCs) transplantation is an attractive and promising treatment strategy for spinal cord injury (SCI). Various pathological processes including the severe inflammatory cascade difficulty in stable proliferation differentiation of NSCs limit its application translation. Here, a novel physico‐chemical bifunctional neural delivery system containing magnetic nanoparticles (MNPs methylprednisolone (MP) designed to repair SCI, former regulates through mechanical...
The progressive worsening of disc degeneration and related nonspecific back pain are prominent clinical issues that cause a tremendous economic burden. Activation reactive oxygen species (ROS) inflammation is primary pathophysiologic change in degenerative lesions. This pathological state associated with M1 macrophages, apoptosis nucleus pulposus cells (NPC), the ingrowth pain-related sensory nerves. To address discogenic pain, we developed MnO2@TMNP, nanomaterial encapsulated MnO2...
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood-spinal barrier (BSCB). To address these challenges, new nano complex that achieves targeted damaged spinal is proposed, which contains mesoporous silica nanoparticle core loaded with microRNA cloaking layer human umbilical mesenchymal stem...
Abstract Traumatic spinal cord injury result in considerable and lasting functional impairments, triggering complex inflammatory pathological events. Spinal scars, often metaphorically referred to as “fire barriers,” aim control the spread of neuroinflammation during acute phase but later hinder axon regeneration stages. Recent studies have enhanced our understanding immunomodulation, revealing that injury-associated inflammation involves various cell types molecules with positive negative...