A5002238001- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- RNA modifications and cancer
- Dental materials and restorations
- Titanium Alloys Microstructure and Properties
- Periodontal Regeneration and Treatments
- biodegradable polymer synthesis and properties
- Graphene and Nanomaterials Applications
- Additive Manufacturing Materials and Processes
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Extraction and Separation Processes
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Wound Healing and Treatments
- Cellular Mechanics and Interactions
- Anatomy and Medical Technology
- Polymer Surface Interaction Studies
Sichuan University
2016-2025
Shandong First Medical University
2013-2025
Shandong Tumor Hospital
2013-2025
China University of Mining and Technology
2024-2025
Dalian Jiaotong University
2024
Academy of Medical Sciences
1998-2023
Shandong Academy of Sciences
2020
Dongyang People's Hospital
2018-2020
Wenzhou Medical University
2018-2020
University of Benin
2020
Polylactic acid/Hydroxyapatite (PLA/HA) composite was widely studied and applied in the field of biomaterials for its good processability, bioactivity, mechanical properties. In addition to traditional preparation methods, additive manufacturing has also been adopted prepare PLA/HA composites with customized geometries. This work combined comprehensive optimized PLLA (L-polylactic acid)/nano-HA (nHA) low-cost stable Fused deposition modeling (FDM) technology successfully PLLA/nHA porous bone...
Objective To profile gut microbiome-associated metabolites in serum and investigate whether these could distinguish individuals with colorectal cancer (CRC) or adenoma from normal healthy individuals. Design Integrated analysis of untargeted metabolomics by liquid chromatography-mass spectrometry metagenome sequencing paired faecal samples was applied to identify significantly altered abundance patients CRC adenoma. The ability discriminate between tested targeted metabolomic analysis. A...
Abstract Osteoporosis, characterized by low bone mass and high fracture risk, challenges orthopedic implant design. Conventional 3D‐printed Ti6Al4V scaffolds are mechanically robust but suffer from poor regeneration in osteoporotic patients due to stress shielding cellular senescence. In this study, a functionalized “Cell Climbing Frame” is developed, aiming adapt the mechanical microenvironment of osteoporosis, effectively recruit support adhesion growth autologous marrow mesenchymal stem...
Long noncoding RNA (lncRNA) HOX transcript antisense (HOTAIR), which could induce genome-wide retargeting of polycomb-repressive complex 2, trimethylates histone H3 lysine-27 (H3K27me3) and deregulation multiple downstream genes, is involved in development progression esophageal squamous cell carcinoma (ESCC). We hypothesized that the functional single nucleotide polymorphisms (SNP) HOTAIR may affect expression and/or its function and, thus, ESCC risk. Therefore, we examined association...
Long noncoding RNA (lncRNA) HOX transcript antisense (HOTAIR) acts as an oncogene in gastric cancer development. HOTAIR could induce genome‐wide retargeting of polycomb‐repressive complex 2, trimethylates histone H3 lysine‐27 (H3K27me3) and deregulation multiple downstream genes. Additionally, the ceRNA miR‐331–3p, may modulate HER2 cells. We hypothesized that functional single nucleotide polymorphisms (SNP) affect expression and/or its function and, thus, risk. examined association between...
Hierarchical porosity, which includes micropores and macropores in scaffolds, contributes to important multiple biological functions for tissue regeneration. This paper introduces a two-step method of combining three-dimensional printing (3DP) microwave sintering fabricate two-level hierarchical porous scaffolds. The results showed that 3D made the macroporous structure well-controlled generated on macropore surface. resulting macro/microporous hydroxyapatite scaffold induced bone formation...
Jaw bone repair requires scaffold with regeneration, antibacterial function and personalized size. This study proposed 3D printed degradable calcium phosphate scaffolds functions for regeneration of jaw bone. Calcium powders berberine were combined to modulate the printing inks. Porous fabricated by direct extrusion cross-linked sodium alginate in situ. The dimensional size, shape porosity precisely customized printing. Berberine-loaded show sustained release antimicrobial drugs. By...
Abstract Zirconium oxide (ZrO 2 ) is the general material in dental area, with natural color, high toughness and strength. Recent years, small blocks of ZrO such as micro/nano powders have been studied developed widely. Nano scale , which show simproved mechanical characteristics superior biocompatibility, are usually incorporated into different applications used dentistry tissue engineering. This review provides an overview nano-ZrO materials its dentistry. The synthesis were mainly...
The macro architecture and micro surface topological morphology of implants play essential roles in bone tissue regeneration.
Abstract Hyaluronic acid (HA) is widely distributed in the human body, and it heavily involved many physiological functions such as tissue hydration, wound repair, cell migration. In recent years, HA its derivatives have been used advanced bioactive polymers for bone regeneration. Many medical products containing developed because this natural polymer has proven to be nontoxic, noninflammatory, biodegradable, biocompatible. Moreover, HA-based composite scaffolds shown good potential...