A5012148448- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Gut microbiota and health
- HER2/EGFR in Cancer Research
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Genomics and Chromatin Dynamics
- SARS-CoV-2 and COVID-19 Research
- Ubiquitin and proteasome pathways
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- Glutathione Transferases and Polymorphisms
- RNA regulation and disease
- Clostridium difficile and Clostridium perfringens research
- PI3K/AKT/mTOR signaling in cancer
- Immunotherapy and Immune Responses
- Caveolin-1 and cellular processes
- Nuclear Structure and Function
Shandong Provincial Hospital
2014-2025
Shandong First Medical University
2022-2025
Shandong University of Traditional Chinese Medicine
2023-2025
Affiliated Hospital of Hebei University
2025
Hebei University of Engineering
2025
Shandong University
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2022
Sun Yat-sen University
2022
National University of Defense Technology
2020
Center for Life Sciences
2013
Long noncoding RNA (lncRNA) HOX transcript antisense (HOTAIR), which could induce genome-wide retargeting of polycomb-repressive complex 2, trimethylates histone H3 lysine-27 (H3K27me3) and deregulation multiple downstream genes, is involved in development progression esophageal squamous cell carcinoma (ESCC). We hypothesized that the functional single nucleotide polymorphisms (SNP) HOTAIR may affect expression and/or its function and, thus, ESCC risk. Therefore, we examined association...
Papillary thyroid carcinoma (PTC) is the most common type of cancer. However, we know little mutational spectrum in Chinese population. Thus, here report identification somatic mutations for PTC using 402 tumor-normal pairs (Discovery: 91 via exome sequencing; validation: 311 Sanger sequencing). We observed three distinct signatures, evidently different from two signatures among Caucasian PTCs. Ten significantly mutated genes were identified, previously uncharacterized. Notably, found that...
Metastasis is a great challenge in lung adenocarcinoma (ADC) therapy. Cholesterol has been implicated ADC metastasis. 4-cholesten-3-one, as cholesterol metabolite and analog, can substitute membrane increase fluidity. In this study, we explored the possibility that 4-cholesten-3-one inhibited Low-dose significantly restrained cells migration invasion with little effects on viabilities. Further investigation showed promoted ROS generation, which transiently activated AMPKα1, increased HIF1α...
Background Anorexia–cachexia syndrome in head and neck cancer (ACSHNC) seriously affects the patient’s quality of life prognosis. Curcumin inhibits anorexic cachexia syndrome. S100A9 is related to tumors, but its role ACSHNC requires further study. Purpose This study intends investigate ACSHNC. Methods In this study, subjects were randomly divided into negative control (NC) group, low-, medium-, high-dose curcumin groups, cell proliferation was detected; flow cytometry detected apoptosis;...
Shenling Baizhu Powder (SBP) is a traditional Chinese medicine (TCM) prescription, which has the good efficacy on gastrointestinal toxicity. In this study, we used gut microbiota analysis, metabonomics and network pharmacology to investigate therapeutic effect of SBP pyrotinib-induced diarrhea.
Immune checkpoint inhibitors (ICIs) are widely used for treating advanced non-small cell lung cancer (NSCLC). However, some studies indicate that patients with genetic mutations do not benefit from immunotherapy. Hence, this study explored the efficacy of anti-programmed death-1 (PD-1) and death-ligand 1 (PD-L1) antibodies in first-line treatment NSCLC driver gene real-world settings.
// Liqing Zhou 1, 2, * , Guobin Fu 3, Jinyu Wei 1 Juan Shi Wenting Pan Yanli Ren Xiangyu Xiong Jianhong Xia 2 Yue Shen Hongliang Li Ming Yang State Key Laboratory of Chemical Resource Engineering, Beijing Biomedical Materials, College Life Science and Technology, University Beijing, China Department Radiation Oncology, Huaian No. Hospital, Huaian, Jiangsu Province, 3 Provincial Hospital Affiliated to Shandong University, Jinan, These authors have contributed equally this work Correspondence...
Severe acute respiratory syndrome coronavirus 2 disease (COVID-19) has caused a worldwide challenging and threatening pandemic. We aimed to assess the safety efficacy of COVID-19 vaccines in Non-Small Cell Lung Cancer (NSCLC) patients. Patient self-reported adverse events related were recorded by follow-up through uniform questionnaire. Survival analysis was performed Kaplan-Meier method. A multivariate Cox proportional hazard regression model determine effect each variable on survival lung...
Background Exposure to cigarette smoke is a major risk factor for lung cancer, but how it induces cancer unclear. The overexpressed in 1 ( OLC1 ) gene one of 50 candidate genes identified by suppression subtractive hybridization as having higher expression squamous cell carcinoma (SCC) than normal epithelia.
Approximately 15-20% of the patients with breast cancer overexpress human epidermal growth factor receptor 2 ( HER2 ). -positive is highly aggressive and has a high relapse rate, suggesting that it prone to progresses rapidly after drug resistance. Pyrotinib resistance changes in patients' conditions are challenging clinical issues require medical attention. Recently, there few reports on pyrotinib We report case 46-year-old patient who developed progressed uncontrolled liver failure less...
Triple-negative breast cancers (TNBC) represent a pathological subtype of cancer, which are characterized by strong invasiveness, high metastasis rate, low survival and poor prognosis, especially in patients who have developed resistance to multiline treatments. Here, we present female patient with advanced TNBC progressed despite multiple lines treatments; next-generation sequencing (NGS) was used find drug mutation targets, revealed coiled-coil domain-containing protein 6...
Atractylenolide III, a sesquiterpene extracted from the rhizome of Atractylodes macrocephala (Asteraceae), exhibits pharmacological effects, including improvement gastrointestinal function, regulation immune anti-inflammatory and antibacterial properties. Pyrotinib, representative TKI originally developed in China, is classified as Class 1.1 novel drug, superior efficacy compared to similar drugs. Notably, overall incidence pyrotinib-induced diarrhea stands at 95 %, with 40 % cases grade ≥3...
Pyrotinib is a novel epidermal growth factor receptor/human receptor-2 (HER2) tyrosine kinase inhibitor that exhibited clinical efficacy in patients with HER2-positive breast cancer and HER2-mutant/amplified lung cancer. However, severe diarrhea adverse responses preclude its practical use. At present, the mechanism of pyrotinib-induced unknown needs further study. First, to develop suitable reproducible animal model, we compared effects different doses pyrotinib (20, 40, 60 80 mg/kg) Wistar...
RAP2B is one of the 50 novel candidate genes cloned from differential expression cDNA libraries constructed in lung cancer cells. Though contains conserved domain and belongs to Ras superfamily, function carcinogenesis still poorly understood. The aim this study explore roles gene carcinogenesis.RT-PCR was applied examine transcriptional status tumor corresponding adjacent tissues collected 27 patients with squamous cell carcinoma. plasmid transfected into Rat1 cells evaluate vitro...
The aim of this study was to assess the efficacy and safety concurrent apatinib docetaxel therapy vs monotherapy as third- or subsequent-line treatment for advanced gastric adenocarcinoma (GAC).Patients, who had received with without third more line GAC, were retrospectively reviewed. Propensity score matching (PSM) analysis performed minimize potential confounding bias. Kaplan-Meier curve log-rank test used analyze survival. Prognostic factors estimated by Cox regression. Adverse events...
Papillary thyroid cancer (PTC) is one of the histological subtypes which most common endocrine malignancy in world. The disrupted balance adenosine-to-inosine (A-to-I) RNA editing due to dysregulation genes exists cancer. However, it still largely unknown how functional single-nucleotide polymorphisms (SNPs) A-to-I contribute PTC genetic susceptibility. In this study, we systematically annotated and investigated role 28 potential SNPs ADAR, ADARB1, ADARB2 AIMP2 PTC. We identified rs904957...
// Jue Wang 1 , Hongchang Shen 2 Guobin Fu Dandan Zhao Weibo Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to University, Jinan, Shandong, China Chemotherapy, Correspondence to: Wang, email: wbwb1620@163.com Keywords: gastric adenocarcinoma, OLC1, IHC, prognosis, subcellular expression Received: November 04, 2016 Accepted: December 15, Published: 26, ABSTRACT We have performed this retrospective study elucidate whether elevated the overexpressed in lung...