A5101897061- Lung Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Pleural and Pulmonary Diseases
- Herpesvirus Infections and Treatments
- Dementia and Cognitive Impairment Research
- Effects of Radiation Exposure
- Sleep and Wakefulness Research
- Cancer Genomics and Diagnostics
- Nutrition and Health in Aging
- RNA modifications and cancer
- Obstructive Sleep Apnea Research
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Frailty in Older Adults
- Erythropoietin and Anemia Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Actinomycetales infections and treatment
- Ultrasound and Hyperthermia Applications
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Adenosine and Purinergic Signaling
Suzhou Municipal Hospital
2024
Nanjing Medical University
2011-2024
Shandong First Medical University
2023-2024
Shandong Provincial Hospital
2023-2024
Huazhong University of Science and Technology
2007-2023
Tongji Hospital
2007-2023
Jiangnan University
2023
Shanghai University of Traditional Chinese Medicine
2023
Shandong University of Finance and Economics
2023
Qilu Hospital of Shandong University
2023
Circulating tumor DNA (ctDNA) has been becoming a novel convenient and noninvasive method for dynamically monitoring landscape of genomic information to guild personalized cancer treatment. In this study we comprehensively evaluated the additional value plasma ctDNA routine tissue next generation sequencing (NGS) therapeutically targetable mutations in lung cancers.The tissues peripheral blood samples from 423 cases patients with were subjected NGS oncodrivers (EGFR, ERBB2, ALK, ROS1, C-MET,...
The aim of the study was to investigate clinical manifestations, diagnosis, treatment, and prognosis primitive neuroectodermal tumors (PNETs) in female genital tract.From April 2001 May 2013, clinicopathologic characteristics, treatments, outcomes, 11 patients with PNET tract were analyzed retrospectively at our hospital.The location presented here included vulva (2 patients), cervix uterus its ligament (5 ovaries patients). Ages ranged from 18 59 years (median, 31 years).The main...
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a novel distinct epileptogenic neoplasm, and its clinical, imaging, histopathological, molecular features were already known in existing literature. We aimed to analyze surgical management PLNTY combined with these characteristics.Eight patients underwent treatment our center between December 2017 2020, postoperative pathology was diagnosed as PLNTY. Their clinical data, pathological, characteristics, seizure outcome...
Corneal fibroblasts exhibit different phenotypes in phases of corneal wound healing. In the inflammatory phase, cells assume a proinflammatory phenotype and produce large amounts cytokines chemokines, but proliferative remodeling phases, they adapt profibrotic state, differentiate into myofibroblasts increase extracellular matrix protein synthesis, secretion, deposition. present study, molecular mechanisms regulating transition from state to were investigated. treated with TGFbeta, known...
Temozolomide (TMZ) is used for the treatment of high-grade gliomas. Acquired chemoresistance a serious limitation to therapy with more than 90% recurrent gliomas showing little response second line chemotherapy. Therefore, it necessary explore an alternative strategy enhance sensitivity glioblastoma (GBM) TMZ in neuro-oncology. Celecoxib well known and widely anti-inflammatory analgesic. Cyclooxygenase-2 (COX-2) expression has been linked prognosis, angiogenesis, radiation many malignancies...
Whilst retinal microvasculature represents cerebral small vessels, the nerve fiber layer is extended white matter of brain. The aim was to investigate correlation between changes in retina and hyperintensities (WMHs).Sixty-four candidates with WMHs received an optical coherence tomography angiography examination. were divided into mild or moderate/severe groups according Fazekas score. After imaging superficial capillary plexus (SCP) deep (DCP), microvascular density parameters (vascular...
The risk factors and potential practice implications of radiation-induced pleural effusion (RIPE) are undefined. This study examined lung cancer patients treated with thoracic radiation therapy (TRT) having follow-up computed tomography (CT) or 18F-fluorodeoxyglucose (FDG) positron emission (PET)/CT. Increased volumes after TRT without evidence tumor progression was considered RIPE. Parameters dose-volume histogram including percent irradiated 5-55 Gy (V5-V55) mean dose (MLD) were analyzed...
Due to the heterogeneity of amyloid β-42 (Aβ42) species, potential correlation between plasma oligomeric Aβ42 (oAβ42) and cognitive impairments in cerebral small vessel disease (CSVD) remains unclear. Herein, a sandwich ELISA for specific detection oligomers total (tAβ42) was developed based on sequence- conformation-specific antibody pairs evaluation samples from Chinese CSVD community cohort. After age gender matching, 3-Tesla magnetic resonance imaging multidimensional assessment were...
Severe acute respiratory syndrome coronavirus 2 disease (COVID-19) has caused a worldwide challenging and threatening pandemic. We aimed to assess the safety efficacy of COVID-19 vaccines in Non-Small Cell Lung Cancer (NSCLC) patients. Patient self-reported adverse events related were recorded by follow-up through uniform questionnaire. Survival analysis was performed Kaplan-Meier method. A multivariate Cox proportional hazard regression model determine effect each variable on survival lung...
Excessive daytime sleepiness (EDS) and cerebral small vessel disease (CSVD) are common problems among older adults; however, their association is not clear. The present study aimed to investigate the frequency of EDS in CSVD patients relationship between neuroimaging markers CSVD.We conducted a cross-sectional 1076 community-dwelling adults aged 55-85 years. was measured using Epworth Sleepiness Scale (ESS), defined as an ESS score greater than 10. Binary logistic regression performed assess...
Background: Physical frailty is a common problem among older adults which usually leads to adverse health outcomes. The imaging markers of cerebral small vessel disease (CSVD) are associated with frailty, but the underlying mechanisms remain unclear. present study aimed investigate mediating role sleep quality in relationship between CSVD burden and frailty. Methods: We performed cross-sectional enrolled community residents. Frailty were measured using Fried phenotype Pittsburgh Sleep...
Objectives:We aimed to identify the risk factors associated with pelvic lymph node metastasis (LNM) at each anatomic location in patients stage IB1 cervical cancer.Methods: A primary cohort of 728 cancer who underwent radical hysterectomy and systematic lymphadenectomy were retrospectively studied.All removed nodes (N=20,134) pathologically examined.The for LNM different regions (obturator, internal iliac, external common iliac) evaluated by multivariate logistic regression...
Background: Studies on the associations between Systemic Immune-Inflammation (SII) and hepatic steatosis in China are still lacking. It is necessary to clarify relationship SII Chinese population. Methods: This study was conducted from January 2022 December 2022. A total of 37,095 participants were enrolled, among them, with 20,709 (55.83%) being males, 16,386 (44.17%) females. Physical biochemical indicators measured during a morning health examination after examinees had fasted overnight....
Recently, there has been increased interest in the relationship between cerebral small vessel disease (CSVD) and circadian rhythm disruption, particularly sleep disturbance. However, neural mechanism of disturbance CSVD patients remains poorly understood. The purpose this study is to explore gray matter alterations with without 59 40 healthy controls (HC) were recruited for present study. Sleep quality was assessed using Pittsburgh Quality Index (PSQI) questionnaire. categorized into either...
Bovine herpesvirus 1 (BHV-1) infection may lead to conjunctivitis, upper respiratory tract problems, pneumonia, genital disorders and abortion. BHV-1 is able spread quickly in a plaque-wise manner invade by breaching the basement membrane (BM) barrier mucosa. Us3, serine/threonine kinase, induces dramatic cytoskeletal reorganization Us9, tail-anchored protein, required for axonal transport of viruses neurons. In this study, we investigated role Us3 Us9 during First, constructed characterized...
Objective To summarize the characteristics of Chinese coccidioidomycosis cases, improve diagnosis and treatment this disease prevent misdiagnosis as well therapeutic error.Methods Search in databases including Medline,Wanfang,and CNKI using "Coccidioidomycosis" "China" index words yielded 23 articles that reported a total 32 cases.In addition,one patient with disseminated coccidioidomycos was treated our center April 2016.The demographic data,site infection,clinical manifestations,past...
In the title-page footnotes of article by Jiang et al in May 2014 issue Arthritis & Rheumatology (pages 1121–1132), institutional affiliations authors who were designated with number 2 byline shown incorrectly. The correct are as follows: Jian Yang, PhD, Peter M. Visscher, PhD: University Queensland, Queensland Diamantina Institute, Translational Research and Brain Brisbane, Australia; Gibran Hemani, Patrick Danoy, MD, Dana Willner, Catherine Cremin, BSc(Hons), Johanna Hadler, Dipl Ing,...
Objective To investigate the correlation between iodine intake, BRAF mutation in thyroid gland and clinical biologic characteristics papillary carcinoma(PTC) cases. Methods A total of 159 PTC patients 200 healthy controls were enrolled this study. Urine was tested, BRAFV600E detected by PCR. The analyzed respectively. Results The median urinary (MUI) 336 μg/L 196 respectively (P=0.004). overall prevalence series 63.5%, showing a clear with intake (P=0.006). There no age, gender,...
Objective To explore the relationship of chemokine receptor 7 (CCR7) and epithelial mesenchymal transition (EMT) in thyroid goiter papillary carcinoma.Methods CCR7,N-cadherin MMP9 were detected by immunohistochemical technique 50 cases tissues carcinoma tissues.The correlation between clinical pathological data CCR7 expression retrospectively analyzed.Results N-cadherin mainly located nodular follicular epithelium (83.7％,90.7％) correlated with each other statistically(P ＜0.01),the low...
Objectives: The study aimed to examine the association of three anemia-related biomarkers with adequacy peritoneal dialysis (PD) in patients chronic kidney disease (CKD). Methods: This included 127 PD patients. total Kt/V urea (Kt/V) was calculated according Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines. All were classified into two groups based on Kt/V, viz., adequate (Kt/V ≥1.7) and inadequate <1.7) groups. Effect sizes are expressed as odds ratios (ORs) 95%...