A5079414919- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Spinal Cord Injury Research
- Stroke Rehabilitation and Recovery
- Acupuncture Treatment Research Studies
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Protein Kinase Regulation and GTPase Signaling
- Extracellular vesicles in disease
- Dementia and Cognitive Impairment Research
- Cancer-related Molecular Pathways
- Cerebral Venous Sinus Thrombosis
- Migraine and Headache Studies
- Neurosurgical Procedures and Complications
- Cardiac Ischemia and Reperfusion
- Antiplatelet Therapy and Cardiovascular Diseases
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2024
Chongqing Medical University
2021-2024
Guangdong Provincial People's Hospital
2021-2023
Guangdong Academy of Medical Sciences
2023
Southern Medical University
2023
Capital Medical University
2021-2022
Guigang City People's Hospital
2016-2021
Jinan University
2018
Early reperfusion of ischemic cardiac tissue remains the most effective intervention for improving clinical outcome following myocardial infarction. However, abnormal increases in intracellular Ca²⁺ during can cause cardiomyocyte death and consequent loss function, referred to as ischemia/reperfusion (IR) injury. Therapeutic modulation handling provides some cardioprotection against paradoxical effects restoring blood flow heart, highlighting significance overload IR Cardiac is also...
Abstract Objective To assess the efficacy of manual acupuncture as prophylactic treatment for naive patients with episodic migraine without aura. Design Multicentre, randomised, controlled clinical trial blinded participants, outcome assessment, and statistician. Setting Seven hospitals in China, 5 June 2016 to 15 November 2018. Participants 150 Interventions 20 sessions at true points plus usual care, non-penetrating sham heterosegmental non-acupuncture or care alone over 8 weeks. Main...
We have demonstrated previously the regulation of Cl<sup>−</sup>/HCO<sub>3</sub><sup>−</sup> exchange activity by cystic fibrosis transmembrane conductance regulator (CFTR) in model systems cells stably or transiently transfected with CFTR (Lee, M. G., Wigley, W. C., Zeng, W., Noel, L. E., Marino, C. R., Thomas, P. J., and Muallem, S. (1999)<i>J. Biol. Chem.</i> 274, 3414–3421). In present work we examine significance this naturally expressing CFTR. These include human colonic T84 cell line...
Background and Purpose: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice developing countries like China needs to be confirmed. aim the study was determine whether EVT acute ischemic stroke randomized trials could generalized Chinese population. Methods: We conducted a prospective registry at 111 centers China. Patients with caused by imaging-confirmed intracranial receiving were included. primary outcome functional independence 90 days defined as...
Abstract Aims The involvement of pyroptosis in ischemic stroke remains to be established. Therefore, we used the specific inhibitor Vx765 as an experimental intervention target a murine model stroke. Methods A total 564 C57BL/6 mice were subjected photothrombotic procedures and treated via gavage with at 1‐hour post‐ischemia. We subsequently assessed expression Gasdermin D (GSDMD), inflammasomes, caspase‐1, interleukin‐1β (IL‐1β) using immunofluorescence (IF) Western blot (WB) analyses. also...
Abstract Background Immediately after spinal trauma, immune cells, and proinflammatory cytokines infiltrate the cord disrupt focal microenvironment, which impedes axon regeneration functional recovery. Previous studies have reported that regulatory T cells (Tregs) enter central nervous system exert immunosuppressive effects on microglia during multiple sclerosis stroke. However, whether how Tregs interact with modulate injured microenvironments injury (SCI) remains unknown. Method Regulatory...
<h3>Background:</h3> The traditional Chinese theory of acupuncture emphasizes that the intensity must reach a threshold to generate <i>de qi,</i> which is necessary achieve best therapeutic effect. <i>De qi</i> an internal compound sensation soreness, tingling, fullness, aching, cool, warmth and heaviness, radiating at around acupoints. However, notion be achieved for maximum benefit has not been confirmed by modern scientific evidence. <h3>Methods:</h3> We performed prospective multicentre...
Background and Purpose: A recent randomized controlled trial DIRECT-MT (Direct Intra-Arterial Thrombectomy to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals) compared the safety efficacy of mechanical thrombectomy (MT) versus combined intravenous thrombolysis (IVT) MT for acute large vessel occlusion. The current study utilized a prospective, nationwide registry validate results real-world practice setting. Methods: Subjects were selected...
Spinal cord injury (SCI) causes neurological dysfunction with devastating consequences. SCI pathogenesis is accompanied by inflammasome activation and neuronal damage. But the spatial pattern time course of pyroptosis apoptosis after should be further elucidated. The microglial voltage-gated proton channel (Hv1) implicated in reactive oxygen species (ROS)-induced damage following ischemic stroke. However, there a lack quantification on associated Hv1 SCI. We analyzed temporal characteristics...
/Objective: In recent years, prostheses have been widely used for limb reconstruction after pelvic tumour resection. However, are associated with problems leading to recurrence, poor implant matching, defects resection, and easy looseness or failure. To achieve a precise preoperative design, complete better anatomical structure matching prosthesis stability, this study three-dimensionally (3D)-printed osteotomy guides personalised This aimed explore the early clinical efficacy of 3D printed...
White matter hyperintensities (WMH) are imaging manifestations frequently observed in various neurological disorders, yet the clinical application of WMH quantification is limited. In this study, we designed a series dedicated labeling protocols and proposed convolutional neural network named 2D VB-Net for segmentation other coexisting intracranial lesions based on large dataset 1,045 subjects across demographics multiple scanners using thick-slice that more commonly applied practice. Using...
Sex disparities in acute large vessel occlusion (LVO) following endovascular treatment (EVT) have been recently reported. However, there is uncertainty about the effect of sex differences on functional outcomes after EVT, particularly an Asian population. The present study aimed to compare clinical and safety between men women with anterior circulation LVO treated EVT.
The renal cortical collecting duct (CCD) plays an important role in systemic acid-base homeostasis. β-intercalated cells secrete most of the HCO[Formula: see text], which is mediated by a luminal, DIDS-insensitive, Cl − /HCO[Formula: text] exchange. identity luminal exchanger matter debate. Anion isoform 4 (AE4) cloned from rabbit kidney was proposed to perform this function (Tsuganezawa H et al. J Biol Chem 276: 8180–8189, 2001). By contrast, it (Royaux IE Proc Natl Acad Sci USA 98:...
Most patients with stroke caused by middle cerebral artery occlusion (MCAO) show cognitive deficit that is generally regarded as resulting from damage to the cortex rather than hippocampus. Whether MCAO induces hippocampal and whether this contributes defects remains unclear. Here we investigate its correlation after exclusively unilateral underlying mechanism for damage.Patients were assessed magnetic resonance imaging (MRI) angiography (MRA), Mini Mental-Status Evaluation (MMSE) Rey...
Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke worldwide. Evolocumab, proprotein convertase subtilisin/kexin type-9 inhibitor (PCSK9i), effectively lowers low-density lipoprotein (LDL) and produces favorable changes in coronary atherosclerosis. This study aimed to determine the effects PCSK9i on intracranial plaques moderate-intensity statin-treated individuals with ICAS.This prospective, observational monitored imaging clinical outcomes ICAS who were consecutively...
Cerebral small vessel disease (CSVD), which is a group of pathological processes affecting cerebral microvessels, leads to functional loss in the elderly population and mostly presents as cognitive impairment gait decline. CSVD diagnosed based on brain imaging biomarkers, but blood biomarkers are great significance for early diagnosis progression prediction have become research focus because their noninvasiveness easy accessibility. Notably, many been reported be associated with relatively...
In patients undergoing mechanical thrombectomy (MT), adjunctive antithrombotic might improve angiographic reperfusion, reduce the risk of distal emboli and reocclusion but possibly expose to a higher intracranial hemorrhage risk. This study evaluated safety efficacy combined MT plus eptifibatide for acute ischemic stroke. was propensity-matched analysis data from 2 prospective trials in Chinese populations: ANGEL-ACT trial (Endovascular Treatment Key Technique Emergency Workflow Improvement...
Abstract Spinal cord injury (SCI) causes severe functional deficits and neuronal damage, accompanied by intense glial activation. The voltage‐gated proton channel Hv1, selectively expressed on microglia, is associated with SCI progression. However, the effect of Hv1 phenotypes functions reactive astrocytes after remains unclear. Here, we combined knockout (Hv1 −/− ) mice T10 spinal contusion to investigate effects microglial pathophysiology astrocytes. After SCI, proliferated activated in...
Increasing evidence indicates that the Eph receptors and their ephrin ligands are involved in regulation of interactions between neurons astrocytes. Moreover, astrocytic ephrin-A3 reverse signaling mediated by EphA4 is necessary for controlling abundance glial glutamate transporters. However, role function neuronal death under ischemic conditions remains unclear. In present study, we found receptor its ligand, which were distributed astrocytes, respectively, hippocampus showed a coincident...
Microglia are critical in damage/repair processes during ischemic white matter injury (WMI). Voltage-gated proton channel (Hv1) is expressed microglia and contributes to nicotinamide adenine dinucleotide phosphate oxidase complex-dependent production of reactive oxygen species (ROS). Recent findings have shown that Hv1 involved regulating luminal pH M1-polarized microglial phagosomes inhibits endocytosis microglia. We previously reported facilitated ROS pro-inflammatory cytokines enhanced...
White matter hyperintensities (WMH) are key markers of cerebral small vessel disease (CSVD) linked to increased risks stroke, dementia, and cognitive decline. Physical activity (PA) has been hypothesized reduce WMH burden preserve brain health, yet findings across studies remain mixed. This study investigates the association between PA burden, as well white integrity using diffusion tensor imaging (DTI) metrics, in a cohort 10,868 participants from UK Biobank.Participants were categorized...
We applied an MRI technique diffusion tensor imaging along the perivascular space (DTI-ALPS) for assessing glymphatic system (GS) in a genome-wide association study (GWAS) and phenome-wide (PheWAS) of 40,486 European individuals. Exploratory analysis revealed 17 genetic loci significantly associating with regional DTI-ALPS index. found 58 genes, including SPPL2C EFCAB5 , which prioritized index subtypes associated neurodegenerative diseases. PheWAS 241 traits suggested that body mass blood...