A5009286509- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Mitochondrial Function and Pathology
- Sperm and Testicular Function
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Nicotinic Acetylcholine Receptors Study
- Signaling Pathways in Disease
- Pluripotent Stem Cells Research
- Hydrocarbon exploration and reservoir analysis
- Cardiac Ischemia and Reperfusion
- Hydraulic Fracturing and Reservoir Analysis
- Cancer, Hypoxia, and Metabolism
- Genetics and Neurodevelopmental Disorders
- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- 3D Printing in Biomedical Research
- Mechanical Circulatory Support Devices
- Hippo pathway signaling and YAP/TAZ
- Cardiac electrophysiology and arrhythmias
- Hematopoietic Stem Cell Transplantation
University of Wisconsin–Madison
1996-2025
Discovery Institute
2025
Sanford Burnham Prebys Medical Discovery Institute
2025
Cairo University
2023-2024
Harvard University
2013-2018
Harvard Stem Cell Institute
2015-2018
Harvard University Press
2017
Brigham and Women's Hospital
2013-2016
The University of Texas Southwestern Medical Center
2010-2014
Southwestern Medical Center
2010-2012
The heart in a newborn mouse can rebuild itself after injury, but this regenerative capacity is lost within few days.
The adult mammalian heart has limited potential for regeneration. Thus, after injury, cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the neonatal can regenerate owing to sustained cardiomyocyte proliferation. Identification of critical regulators proliferation quiescence represents an important step toward regenerative therapies. Yes-associated protein (Yap), a transcriptional cofactor in Hippo signaling pathway, promotes embryonic by activating...
Myocardial infarction (MI) leads to cardiomyocyte death, which triggers an immune response that clears debris and restores tissue integrity. In the adult heart, system facilitates scar formation, repairs damaged myocardium but compromises cardiac function. neonatal mice, heart can regenerate fully without scarring following MI; however, this regenerative capacity is lost by P7. The signals govern regeneration are unknown. By comparing MI in mice at P1 P14, we identified differences magnitude...
We recently identified a brief time period during postnatal development when the mammalian heart retains significant regenerative potential after amputation of ventricular apex. However, one major unresolved question is whether neonatal mouse can also regenerate in response to myocardial ischemia, most common antecedent failure humans. Here, we induced ischemic infarction (MI) 1-d-old mice and found that this results extensive necrosis systolic dysfunction. Remarkably, mounted robust...
Early reperfusion of ischemic cardiac tissue remains the most effective intervention for improving clinical outcome following myocardial infarction. However, abnormal increases in intracellular Ca²⁺ during can cause cardiomyocyte death and consequent loss function, referred to as ischemia/reperfusion (IR) injury. Therapeutic modulation handling provides some cardioprotection against paradoxical effects restoring blood flow heart, highlighting significance overload IR Cardiac is also...
Neonatal mouse cardiomyocytes undergo a metabolic switch from glycolysis to oxidative phosphorylation, which results in significant increase reactive oxygen species production that induces DNA damage. These cellular changes contribute cardiomyocyte cell cycle exit and loss of the capacity for cardiac regeneration. The mechanisms regulate this have been relatively unexplored. Current evidence suggests elevated ischemic tissues occurs as result accumulation mitochondrial metabolite succinate...
Abstract Baltim Eastern and Northern gas fields in the offshore Nile Delta have very high condensate accumulations. Therefore, present research evaluates Abu Madi Qawasim Formations defines petrophysical parameters for them using various data from five wells composed of wireline logs (gamma-ray, density, neutron, sonic, resistivity), core data, pressure cross-plots. In current study, formations main reservoirs were evaluated qualitatively quantitatively based on analysis to assess production...
Sympathetic innervation influences homeostasis, repair, and pathology in the cardiac ventricles; contrast, parasympathetic is considered to have minimal contribution influence ventricles. Here, we use genetic models, whole-mount imaging, three-dimensional modeling define nerve architecture during development, disease, regeneration. Our approach reveals that nerves extensively innervate Furthermore, identify sympathetic axons develop synchronously are bundled throughout We further investigate...
Adult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the potential for heart regeneration. Endogenous cardiomyocyte proliferation is preceded by dedifferentiation (CMDD), wherein adult revert to a less matured state that distinct from classical myocardial fetal stress gene response associated with failure. However, very little known about CMDD as defined cell transition.
Abstract Aims Adult mammalian cardiomyocytes have limited regenerative potential, and after myocardial infarction (MI), injured cardiac tissue is replaced with fibrotic scar. In contrast, the neonatal mouse heart possesses a capacity governed by cardiomyocyte proliferation; however, metabolic switch from glycolysis to fatty acid oxidation during postnatal development results in loss of this capacity. Interestingly, sarcomere isoform also takes place where slow skeletal troponin I (ssTnI)...
The PTAH oil field in Egypt's northern Western Desert offers considerable potential for hydrocarbon production. This research centers on the Shiffah formation and evaluates its petrophysical properties using data from four wells. analysis involves wireline logs (including gamma-ray, density, neutron, sonic, resistivity), core samples, pressure readings, cross-plots. A combination of qualitative quantitative techniques was employed to assess formation's hydrocarbon-bearing capacity. primarily...
Eight different lectins conjugated to fluorescein isothiocyanate (FITC) were used screen for sperm plasma membrane changes during in vitro capacitation of bovine sperm. Analysis lectin binding was done using flow cytometry. Of the eight lectins, only Triticum vulgaris (wheat germ agglutinin, WGA) altered with capacitation. Capacitation by heparin found decrease WGA 78% (P < 0.05). The effect oviduct fluid next compared inhibiting glucose on also determined. WGA-bound detected cytometry as...