A5021245954- Wastewater Treatment and Nitrogen Removal
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Microbial Community Ecology and Physiology
- DNA Repair Mechanisms
- Water Treatment and Disinfection
- Constructed Wetlands for Wastewater Treatment
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Genomics and Chromatin Dynamics
- Corporate Finance and Governance
- Financial Markets and Investment Strategies
- Advanced biosensing and bioanalysis techniques
- Genetic factors in colorectal cancer
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Drug Transport and Resistance Mechanisms
- Cell death mechanisms and regulation
- Ion channel regulation and function
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Ammonia Synthesis and Nitrogen Reduction
- Genomics and Phylogenetic Studies
- Liver Disease and Transplantation
Peking University
2016-2025
First Affiliated Hospital of Nanchang University
2024-2025
Nanchang University
2024-2025
Shenyang Medical College
2006-2025
Chinese Academy of Sciences
2013-2024
Shihezi University
2015-2024
Research Center for Eco-Environmental Sciences
2013-2024
State Key Laboratory of Natural and Biomimetic Drugs
2022-2024
Beijing Forestry University
2024
Tianjin University
2013-2024
Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes 1 deaths each year. Tenfold shotgun sequence coverage was obtained from PEST strain A. assembled into scaffolds span 278 base pairs. A total 91% genome organized in 303 scaffolds; largest scaffold 23.1 There substantial genetic variation within this strain, apparent existence two haplotypes approximately equal frequency ("dual haplotypes") fraction likely reflects outbred...
<b><i><i>Background:</i></i></b> Hyperglycemia at the time of acute ischemic stroke has been linked to worse outcome in both human and animal studies. <b><i><i>Objective:</i></i></b> To describe prevalence severity hyperglycemia on hospital admission among patients, examine independent relationship all-cause mortality, document inpatient management hyperglycemia. <b><i><i>Methods:</i></i></b> Patients hospitalized with one from July 1993 June 1998 (n = 656) were identified. Demographic data,...
T regulatory (Treg) cells are crucial to maintain immune tolerance and repress antitumor immunity, but the mechanisms governing their cellular redox homeostasis remain elusive. We report that glutathione peroxidase 4 (Gpx4) prevents Treg from lipid peroxidation ferroptosis in regulating immunity. Treg-specific deletion of Gpx4 impairs without substantially affecting survival at steady state. Loss results excessive accumulation peroxides upon cell receptor (TCR)/CD28 co-stimulation....
Abstract Microbial communities are responsible for biological wastewater treatment, but our knowledge of their diversity and function is still poor. Here, we sequence more than 5 million high-quality, full-length 16S rRNA gene sequences from 740 treatment plants (WWTPs) across the world use to construct ‘MiDAS 4’ database. MiDAS 4 an amplicon variant resolved, reference database with a comprehensive taxonomy domain species level all sequences. We independent dataset (269 WWTPs) show that 4,...
ABSTRACT We characterized the bacterial populations in surface water receiving effluent from an oxytetracycline (OTC) production plant. Additional sampling sites included river 5 km upstream and 20 downstream discharge point. High levels of OTC were found wastewater (WW), antibiotic was still detectable (RWD), with undetectable (RWU). A total 341 strains isolated using nonselective media, majority being identified as Gammaproteobacteria . The MICs determined for 10 antibiotics representing...
Naringenin, a flavonoid compound with strong anti-inflammatory activity, attenuated non-alcoholic fatty liver disease (NAFLD) induced by methionine-choline deficient (MCD) diet in mice. However, the mechanisms underlying this suppression of inflammation and NAFLD remain unknown.WT NLRP3-/- mice were fed MCD for 7 days to induce given naringenin gavage at same time. vitro experiments used HepG2 cells, primary hepatocytes, Kupffer cells (KCs) stimulated LPS or plus oleic acid (OA).Treating WT...
The high degree of similarity between the mouse and human genomes is demonstrated through analysis sequence chromosome 16 (Mmu 16), which was obtained as part a whole-genome shotgun assembly genome. genome about 10% smaller than genome, owing to lower repetitive DNA content. Comparison structure protein-coding potential Mmu with that homologous segments identifies regions conserved synteny chromosomes (Hsa) 3, 8, 12, 16, 21, 22. Gene content order are highly syntenic blocks Of 731 predicted...
Purpose. This study examines relationships between overweight in children and two environmental factors—amount of vegetation surrounding a child's place residence proximity the to various types food retail locations. We hypothesize that living greener neighborhoods, farther from fast restaurants, closer supermarkets would be associated with lower risk overweight. Design. Cross-sectional study. Setting. Network primary care pediatric clinics Marion County, Indiana. Subjects. acquired data for...
Mutations in the gene encoding for K + channel α-subunit KCNQ1 have been associated with long QT syndrome and deafness. Besides heart inner ear epithelial cells, is expressed a variety of cells including renal proximal tubule gastrointestinal tract cells. At these sites, cellular ions exit through complexes, which may serve to recycle or maintain cell membrane potential thus driving force electrogenic transepithelial transport, e.g., Na /glucose cotransport. Employing pharmacologic...
A whole-genome restriction map of Deinococcus radiodurans , a radiation-resistant bacterium able to survive up 15,000 grays ionizing radiation, was constructed without using DNA libraries, the polymerase chain reaction, or electrophoresis. Very large, randomly sheared, genomic fragments were used construct maps from individual molecules that assembled into two circular overlapping (2.6 and 0.415 megabases), gaps. third smaller chromosome (176 kilobases) identified characterized. Aberrant...
Hepatocellular carcinoma (HCC) displays a high resistance to tumor necrosis factor–related apoptosis–inducing ligand (TRAIL)–mediated cell death. To increase sensitivity of HCC cells TRAIL, we have constructed an oncolytic adenoviral vector (ZD55) and used this deliver second mitochondria-derived activator caspases (Smac) TRAIL genes (ZD55-Smac ZD55-TRAIL, respectively) into cells. Our data showed that human express levels inhibitor apoptosis proteins (IAPs). Transfected expressing exogenous...
• Background Acute pain is common after cardiac surgery and can keep patients from participating in activities that prevent postoperative complications. Accurate assessment understanding of are vital for providing satisfactory control optimizing recovery. Objectives To describe levels 5 expected on days 1 to 6 changes chest tube removal extubation. Methods Adults who underwent were asked rate the associated with various types 6. Pain compared by day, activity, type surgery. scores before...
Transcriptional insulators are specialized cis-acting elements that protect promoters from inappropriate activation by distal enhancers.The H19 imprinting control region (ICR) functions as a CTCF-dependent, methylation-sensitive transcriptional insulator.We analyzed several insertional mutations and demonstrate the ICR can function methylation-regulated maternal chromosome-specific insulator in novel chromosomal contexts.We used chromosome conformation capture chromatin immunoprecipitation...
The optimal route of estrogen replacement in Turner syndrome (TS) is unknown.The objective the study was to compare conjugated oral vs. transdermal (TD E2) on bone accrual, uterine growth, pubertal development, IGF-I, and lipids girls with TS.Prepubertal GH-treated aged 10 yr or older TS were eligible. Subjects randomized TD E2 for 1 yr. Assessments included dual-emission x-ray absorptiometry, pelvic ultrasound, Tanner staging, growth velocity, lipid profile.Twelve (14.0 +/- 1.7 yr)...
Although siRNA techniques have been broadly applied as a tool for gene knockdown, substantial challenges remain in achieving efficient delivery and vivo efficacy. In particular, the low efficiency of target silencing is critical limiting step to clinical application therapies. Poly(amidoamine) (PAMAM) dendrimers are widely used carriers drug delivery; however, by PAMAM remains be carefully investigated. this study, effectiveness G5 G6 with 8% their surface amines conjugated MPEG-5000 was...
Large-scale epidemiological studies have revealed a strong association between hypertriglyceridemia and coronary arteriosclerotic disease. However, there are conflicting reports whether the severe caused by lipoprotein lipase (LPL) deficiency is pro- or antiatherogenic. To determine effect of LPL on atherosclerosis, we pursued long-term observation development atherosclerotic lesions in an gene deficient mouse model. At 4 months age, homozygous LPL-deficient mice exhibited but no signs...
Interferon regulatory factor 3 (IRF3) plays a crucial role in mediating cellular responses to virus intrusion. The protein kinase TBK1 is key regulator inducing phosphorylation of IRF3. mechanisms during IRF3 activation remain poorly characterized. In the present study, we have identified by yeast two-hybrid approach specific interaction between and chaperone heat-shock 90 kDa (Hsp90). C-terminal truncation mutant Hsp90 strong dominant-negative inhibitor activation. Knockdown endogenous RNA...