A5103074573- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Photodynamic Therapy Research Studies
- RNA modifications and cancer
- Proteoglycans and glycosaminoglycans research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Veterinary Oncology Research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Glycosylation and Glycoproteins Research
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Advanced Proteomics Techniques and Applications
- Lymphatic System and Diseases
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Breast Cancer Treatment Studies
China Medical University
2013-2025
First Hospital of China Medical University
2013-2025
University of Kansas Medical Center
2007-2025
Xi'an Jiaotong University
2021-2024
Huazhong University of Science and Technology
2021-2023
China Agricultural University
2023
Institute of Genetics and Developmental Biology
2022
Hubei University of Arts and Science
2022
University of Kansas
2009-2021
Union Hospital
2021
Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes 1 deaths each year. Tenfold shotgun sequence coverage was obtained from PEST strain A. assembled into scaffolds span 278 base pairs. A total 91% genome organized in 303 scaffolds; largest scaffold 23.1 There substantial genetic variation within this strain, apparent existence two haplotypes approximately equal frequency ("dual haplotypes") fraction likely reflects outbred...
The Clinical Proteomic Tumor Analysis Consortium (CPTAC), under the auspices of National Cancer Institute's Office Proteomics Research, is a comprehensive and coordinated effort to accelerate understanding molecular basis cancer through application proteomic technologies workflows clinical tumor samples with characterized genomic transcript profiles. consortium analyzes biospecimens using mass spectrometry, identifying quantifying constituent proteins characterizing each sample's proteome....
The integration of mass spectrometry-based proteomics with next-generation DNA and RNA sequencing profiles tumors more comprehensively. Here this "proteogenomics" approach was applied to 122 treatment-naive primary breast cancers accrued preserve post-translational modifications, including protein phosphorylation acetylation. Proteogenomics challenged standard cancer diagnoses, provided detailed analysis the ERBB2 amplicon, defined tumor subsets that could benefit from immune checkpoint...
The toll-like receptor 7 and 8 (TLR7/8) agonist Resiquimod (R848) has been recognized as a promising immunostimulator for the treatment of cutaneous cancers in multiple clinical trials. However, systemic administration R848 often results strong immune-related toxicities while having limited therapeutic effects to tumor. In present study, prodrug-based nanocarrier delivery system was developed that exhibited high efficiency. conjugated α-tocopherol constitute an R848-Toco prodrug, followed by...
Abstract Background As a metabolic reprogramming feature, cancer cells derive most of their energy from aerobic glycolysis, while its regulatory mechanisms and therapeutic strategies continue to be illusive. Methods Integrative analysis publically available expression profile datasets was used identify critical transcriptional regulators target glycolytic enzymes. The functions acting in were investigated by using vitro vivo assays. Kaplan–Meier curve log‐rank assay conduct the survival...
Background: Hyaluronan (HA) is a ligand for the CD44 receptor which crucial to cancer cell proliferation and metastasis. High levels of expression in many cancers have encouraged development HA-based carriers anti-cancer therapeutics.Purpose: The objective this study was determine whether HA conjugation anticancer drugs impacts CD44-specific HA-drug uptake disposition by human head neck cells.Methods: internalization cellular hyaluronan-doxorubicin (HA-DOX), hyaluronan-cisplatin (HA-Pt),...
4 Background: Metastatic penile squamous cell carcinoma (mPSCC) is a rare and aggressive malignancy with limited treatment options. Standard systemic therapies include paclitaxel, ifosfamide, cisplatin (TIP), fluorouracil (5-FU + cis), paclitaxel monotherapy cetuximab. These regimens were evaluated as small single-arm studies. The HERCULES trial, phase 2 clinical study, demonstrated the safety efficacy of combining immunotherapy chemotherapy, signaling potential benefit immunotherapy. Our...
ABSTRACT Docosahexaenoic acid (DHA) and nervonic (NA) are the main components of brain gray white matter, respectively. Preclinical clinical studies suggest effects DHA or NA supplementation on memory improvement in aging Alzheimer's disease models. However, it is not yet clear whether dietary with can enhance by increasing their levels matter. The present study aimed to examine spatial matter lipidomic profiles adolescent mice without a NA‐enriched diet. Spatial conditional fear were...
New lymphatic imaging technologies are needed to better assess immune function and cancer progression treatment. Lymphatic uptake depends mainly on particle size (10-100 nm) charge. The of carriers for drug delivery can be optimized maximize uptake, localize chemotherapy metastases, enable visualization treatment deposition. Toward this end, female BALB/c mice were injected subcutaneously in the hind footpad or forearm with a series six different molecular weight hyaluronan (HA)...