A5073239054- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Immune cells in cancer
- Metabolism and Genetic Disorders
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Amino Acid Enzymes and Metabolism
- Ion channel regulation and function
- Cellular transport and secretion
- Nicotinic Acetylcholine Receptors Study
- Immune Response and Inflammation
- Neuroblastoma Research and Treatments
- Insect-Plant Interactions and Control
- Cancer therapeutics and mechanisms
- AI in cancer detection
- Cytokine Signaling Pathways and Interactions
- Dental Radiography and Imaging
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Treatments and Mutations
- Cell Adhesion Molecules Research
- Oral microbiology and periodontitis research
Southern Medical University
2025
Nanfang Hospital
2025
Sichuan Cancer Hospital
2024
Huazhong University of Science and Technology
2021-2023
Union Hospital
2021-2023
Ministry of Education of the People's Republic of China
2023
Anhui Medical University
2023
First Affiliated Hospital of Anhui Medical University
2023
University of Georgia
2017-2022
Jilin University
2022
Background We explore sphingolipid-related genes (SRGs) in skin melanoma (SKCM) to develop a prognostic indicator for patient outcomes. Dysregulated lipid metabolism is linked aggressive behavior various cancers, including SKCM. However, the exact role and mechanism of sphingolipid remain partially understood. Methods integrated scRNA-seq data from patients sourced GEO database. Through utilization Seurat R package, we successfully identified distinct gene clusters associated with survival...
Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as novel transcriptional activator cytoprotective autophagy crucial for zinc homeostasis cancer cells. Gain- loss-of-function studies showed that promoted cell cycle-dependent manner, resulting facilitated degradation MT...
Abstract Considerable metabolic reprogramming has been observed in a conserved manner across multiple cancer types, but their true causes remain elusive. We present an analysis of around 50 such reprogrammed metabolisms (RM) including the Warburg effect, nucleotide de novo synthesis, and sialic acid biosynthesis cancer. Analyses biochemical reactions conducted by these RMs, coupled with gene expression data catalyzing enzymes, 7,011 tissues 14 revealed that all RMs produce more H+ than...
Although it has been postulated that vesicle mobility is increased to enhance release of transmitters and neuropeptides, the mechanism responsible for increasing motion in nerve terminals effect perturbing this mobilization on synaptic plasticity are unknown. Here, green fluorescent protein-tagged dense-core vesicles (DCVs) imaged Drosophila motor neuron terminals, where DCV minutes after seconds activity. Ca2+-induced Ca2+ from presynaptic endoplasmic reticulum (ER) shown be necessary...
Non-small cell lung cancer (NSCLC) is one of the most commonly diagnosed malignancies in world. Small-molecule inhibitors EGF receptor's tyrosine kinase domain (TKIs), including gefitinib and erlotinib, have been widely used for treating NSCLC. Unfortunately, nearly all patients after initially experiencing a marked improvement while on these drugs, eventually progress to acquire resistance TKIs. Because there no effective therapeutic strategy treat TKI-resistant NSCLC, we evaluated effects...
Abstract Background As a metabolic reprogramming feature, cancer cells derive most of their energy from aerobic glycolysis, while its regulatory mechanisms and therapeutic strategies continue to be illusive. Methods Integrative analysis publically available expression profile datasets was used identify critical transcriptional regulators target glycolytic enzymes. The functions acting in were investigated by using vitro vivo assays. Kaplan–Meier curve log‐rank assay conduct the survival...
Neuroblastoma is the most common extracranial solid malignancy in children. This study was undertaken to determine long-term survival of neuroblastoma patients receiving conventional therapeutics (surgery, chemotherapy, and radiotherapy). The examined were registered Surveillance, Epidemiology End Results (SEER) database (1975-2016). Using propensity score matching analysis, paired by record depending on whether they received surgery, or radiotherapy. Univariate multivariate analyses...
Culturing embryonic stem cells (ESCs) in vitro usually requires animal-derived trophoblast cells, which may cause pathogenic and immune reactions; moreover, the poor repeatability between batches hinders clinical application of ESCs. Therefore, it is essential to synthesize a xenogeneic-free chemically well-defined biomaterial substrate for maintaining ESC pluripotency. Herein, effects structurally tunable reduced graphene oxide (RGO) substrates with different physicochemical properties on...
Sialic acids (SA), negatively charged nine-carbon sugars, have long been implicated in cancer metastasis since 1960's but its detailed functional roles remain largely elusive. We present a computational analysis of transcriptomic data vs. control tissues eight types TCGA, aiming to elucidate the possible reason for increased production and utilization SAs their driving migration. Our analyses revealed all types: (1) synthesis deployment enzymes are persistently up-regulated throughout...
Periodontitis is a prevalent and irreversible chronic inflammatory disease both in developed developing countries, affects about 20–50% of the global population. The tool for automatically diagnosing periodontitis highly demanded to screen at-risk people its early detection could prevent onset tooth loss, especially local communities health care settings with limited dental professionals. In medical field, doctors need understand trust decisions made by computational models interpretable...
Background: Podocyte injury leading to proteinuria is the primary feature of a vast majority glomerular diseases, while mesangial cell activation hallmark glomerulosclerosis. Whether and how these two events are connected remains elusive. In this study, we investigated role extracellular vesicles (EVs) in linking podocyte disease. Methods: EVs were characterized by nanoparticle tracking analysis electron microscopy. Differentially expressed proteins from podocyte-derived analyzed protein...
Antibody-based therapies are at the forefront of modern medicine, addressing diverse challenges across oncology, autoimmune diseases, infectious and beyond. The ability to design antibodies with enhanced functionality specificity is critical for advancing next-generation therapeutics. Recent advances in artificial intelligence (AI) have propelled field antibody engineering, particularly through inverse folding models Complementarity-Determining Region (CDR) sequence design. These aim...
It is an open question how ion channel subunits that lack protein–protein binding motifs become targeted and covalently modified by cellular signaling enzymes. Here, we show Src-family protein tyrosine kinases (PTKs) bind to heteromultimeric Shaker -family voltage-gated potassium (Kv) channels interactions between the Src homology 3 (SH3) domain proline-rich SH3 ligand sequence in subunit Kv1.5. Once bound Kv1.5, PTKs phosphorylate adjacent Kv heteromultimer sequences. This SH3-dependent...
Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as key negative regulator for activation and signaling may be involved RA pathogenesis. In this study, we analyzed expression level A20, NF-κB, regulatory factor mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) patients with Real-time PCR used to determine MALT1, MALT-V1, NF-κB genes healthy individuals...
Abstract Triple negative breast cancer (TNBC) represents the most malignant subtype of cancer, and yet our understanding about its unique biology remains elusive. We have conducted a comparative computational analysis transcriptomic data TNBC non-TNBC (NTNBC) tissue samples from TCGA database, focused on genes involved in neural functions. Our main discoveries are: (1) while both subtypes involve functions, has substantially more up-regulated than NTNBC, suggesting that is complex NTNBC; (2)...
Abstract Acid–base homeostasis is a fundamental property of living cells, and its persistent disruption in human cells can lead to wide range diseases. In this study, we conducted computational modeling analysis transcriptomic data 4750 tissue samples 9 cancer types The Cancer Genome Atlas (TCGA) database. Built on our previous quantitatively estimated the average production rate OH− by cytosolic Fenton reactions, which continuously disrupt intracellular pH (pHi) homeostasis. Our predictions...
A potential therapeutic approach for cancer treatment is target oxidative phosphorylation and glycolysis simultaneously. The matrix protein of vesicular stomatitis virus (VSV MP) can the surface mitochondria, causing morphological changes that may be associated with mitochondrial dysfunction inhibition. Previous research has shown abnormalities direct glucose metabolism toward glycolysis. Thus, after VSV MP, inhibition necessary to completely block eradicate cancer. Here, inhibit glycolysis,...