A5011658361- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanofabrication and Lithography Techniques
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Electron Spin Resonance Studies
- Monoclonal and Polyclonal Antibodies Research
- Photoreceptor and optogenetics research
- Protein Interaction Studies and Fluorescence Analysis
- Crystallography and molecular interactions
- CAR-T cell therapy research
Karlsruhe Institute of Technology
2020-2022
Antibody-based therapies are at the forefront of modern medicine, addressing diverse challenges across oncology, autoimmune diseases, infectious and beyond. The ability to design antibodies with enhanced functionality specificity is critical for advancing next-generation therapeutics. Recent advances in artificial intelligence (AI) have propelled field antibody engineering, particularly through inverse folding models Complementarity-Determining Region (CDR) sequence design. These aim...
Three shape-persistent [4+4] imine cages with truncated tetrahedral geometry different window sizes were studied as hosts for the encapsulation of tetra-n-alkylammonium salts various bulkiness. In solvents behave differently. For instance, in dichloromethane cage smallest size takes up NEt4+ but not NMe4+, which is contrast to two larger windows hosting both ions. To find out reason this, kinetic experiments carried determine velocity uptake also deduce activation barriers these processes....
Abstract Antibody-based therapies are at the forefront of modern medicine, addressing diverse challenges across oncology, autoimmune diseases, infectious and beyond. The ability to design antibodies with enhanced functionality specificity is critical for advancing next-generation therapeutics. Recent advances in artificial intelligence (AI) have propelled field antibody engineering, particularly through inverse folding models Complementarity-Determining Region (CDR) sequence design. These...
Fluorophores linked to the glucose/galactose-binding protein (GGBP) are a promising class of glucose sensors with potential application in medical devices for diabetes patients. Several different fluorophores at positions were tested experimentally so far, but deeper molecular understanding their function is still missing. In this work, we use dynamics simulations investigate mechanism binding GGBP-Badan triple mutant and make comparison GGBP wild-type protein. The aim achieve detailed...