A5100368110- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Circular RNAs in diseases
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Sperm and Testicular Function
- CRISPR and Genetic Engineering
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- IL-33, ST2, and ILC Pathways
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- RNA Research and Splicing
- Immune cells in cancer
- Pancreatic function and diabetes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Animal Genetics and Reproduction
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
Xiamen University
2022-2025
Soochow University
2010-2025
Dalian Medical University
2012-2025
First Affiliated Hospital of Dalian Medical University
2017-2025
Northwest A&F University
2016-2025
Second Affiliated Hospital of Kunming Medical College
2024-2025
Tianjin Medical University
2015-2025
Ministry of Agriculture and Rural Affairs
2025
Hainan Medical University
2023-2025
First Affiliated Hospital of Xiamen University
2022-2025
<ns4:p>Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages dendritic cells. IL-10 IL-12 play very important immunoregulatory roles in host defense immune homeostasis. Being anti- pro-inflammatory nature, respectively, their functions antagonistically opposing. A comprehensive in-depth understanding of immunological properties signaling mechanisms will help develop better clinical intervention strategies therapy for...
Abstract Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1% men, are currently limited by the incomplete understanding NOA pathogenesis and normal spermatogenic microenvironment. Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning range infant to adult 7 patients. We show that Sertoli cells, form scaffold in microenvironment, severely damaged patients identify roadmap cell maturation. Notably, cells...
Galectin-3, an attractive molecule of innate immunity, has been reported to be involved in the neuroinflammatory diseases. However, role Galectin-3 autoimmune uveitis is still unclear. The purpose this study was investigate effect and mechanism on microglial activation inflammation experimental (EAU). We immunized female C57BL/6 J mice with IRBP651-670 induce EAU specific inhibitor intravitreally injected mice. Disease severity evaluated by clinical histopathological scores....
In an effort to examine signaling pathway of inflammation the mouse liver caused by intragastric administration titanium dioxide nanoparticles (NPs), we assessed Toll-like receptor-2 (TLR2), TLR-4, IκB kinase (IKK-α, IKK-β), nucleic factor-κB (NF-κB), NF-κBP52, NF-κBP65, tumor necrosis factor-α (TNF-α), NF-κB-inducible (NIK), interleukin-2 (IL-2), biochemical parameters functions, and histopathological changes ultrastructure in TiO(2) NPs-treated mice. The results showed accumulation liver,...
Epigenetic dysregulation has emerged as a major contributor to tumorigenesis. Histone methylation is well-established mechanism of epigenetic regulation that dynamically modulated by histone methyltransferases and demethylases. The pathogenic role modifiers in non-small cell lung cancer (NSCLC), which the leading cause deaths worldwide, remains largely unknown. Here, we found H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 JHDM1A) frequently overexpressed NSCLC tumors lines. its...
Abstract It is well known that bone marrow‐derived mesenchymal stem cells (MSCs) are involved in wound healing and regeneration responses. In this study, we globally profiled the proteome of MSCs to investigate critical factor(s) may promote healing. Cysteine‐rich protein 61 (Cyr61) was found be abundantly present MSCs. The presence Cyr61 confirmed by immunofluorescence staining immunoblot analysis. Moreover, showed culture medium (secretome) secretome stimulates angiogenic response vitro,...
Purpose: Dry eye (DE) is a common ocular surface disease, particularly among women and the elderly, with chronic symptoms of irritation and, in severe cases, blurred vision. Several studies have shown that there an inflammatory component DE, although pathogenesis not thoroughly understood. Resolvin E1 (RvE1; RX-10001) endogenous mediator derived from omega-3 polyunsaturated fatty acid eicosapentaenoic involved inflammation resolution tissue protection. Here we investigated role RvE1 DE mouse...
Adipose-derived mesenchymal stem cells (ADMSCs) can self-renew and are multipotent being reportedly able to differentiate into multiple cell types, such as adipocytes, chondrocytes, osteoblasts, neuronal cells, myocytes [1].ADMSCs transplantation has already proven effective against severe traumatic, autoimmune, metabolic, degenerative diseases.However, ADMSCs, similar other types of (MSCs), cannot expand infinitely in vitro [2,3].Senescence during culture reduces the quality clinical...
Abstract The CRISPR/Cas9 system provides a flexible approach for genome engineering of genetic loci. Here, we successfully achieved precise gene targeting in sheep by co-injecting one-cell-stage embryos with Cas9 mRNA and RNA guides three genes ( MSTN , ASIP BCO2 ). We carefully examined the sgRNAs:Cas9-mediated effects injected embryos, somatic tissues, as well gonads via cloning sequencing. efficiencies these were within range 27–33% generated lambs that simultaneously was 5.6%, which...
Pharmacological induction of NRF2 restores redox homeostasis and slows cystogenesis in mouse models polycystic kidney disease.
Nuclear factor erythroid 2-related 2 (NRF2) is a well-characterized transcription that protects cells against oxidative and electrophilic stresses. Emerging evidence has suggested NRF2 DNA damage by mechanisms other than antioxidation, yet the mechanism remains poorly understood. Here, we demonstrate knockout of in results hypersensitivity to ionizing radiation (IR) presence or absence reactive oxygen species (ROS). Under ROS scavenging conditions, induction double-strand breaks (DSBs)...