A5048374246- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Genetic Syndromes and Imprinting
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- CRISPR and Genetic Engineering
- Cardiac tumors and thrombi
- Pain Mechanisms and Treatments
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Virology and Viral Diseases
- Circular RNAs in diseases
- FOXO transcription factor regulation
- Peptidase Inhibition and Analysis
Tianjin Medical University Cancer Institute and Hospital
2023-2025
Tianjin Medical University
2018-2022
Second Hospital of Tianjin Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2017
Lanzhou University
2011
Pharmacological induction of NRF2 restores redox homeostasis and slows cystogenesis in mouse models polycystic kidney disease.
Non-small-cell lung cancer (NSCLC) is one of the most commonly diagnosed cancers worldwide but has limited effective therapies. Uncovering underlying pathological and molecular changes, as well mechanisms, will improve treatment. Dysregulated microRNAs (miRNAs) have been proven to play important roles in initiation progression various cancers, including NSCLC. In this manuscript, we identified microRNA-135b (miR-135b) a tumor-promoting miRNA We found that miR-135b was significantly...
P-TEFb activation by cAMP-PKA signaling promotes cystogenic gene transcription elongation and disease progression in ADPKD.
Radiotherapy is becoming one major therapeutics for non-small cell lung cancer (NSCLC). Identifying novel radiosensitizers will greatly increase the efficacy of radiotherapy and benefit more patients. OTU deubiquitinase 4 (OTUD4) has been reported involved in DNA damage repair pathways could be a potential target chemotherapy therapy. This study aimed to investigate roles OTUD4 regulation radiosensitivity NSCLC via modulating repair. The expression OTUD4, γ-H2Ax ATM/CHK2/p53 pathway-related...
As the third most common cause of cancer-related mortality, hepatocellular carcinoma (HCC) is a global health concern. Despite its prevalence, treatment options are limited, underscoring need to identify potential therapeutic targets and strategies. Here, we identified amplification CRTC2, situated in 1q21.3 region, due copy number alterations HCC. In cohort patients with HCC, CRTC2 protein levels were frequently elevated correlated poor prognosis. Genetic deletion significantly impeded...
Prostate tumor over expressed gene 1 (PTOV1) has been reported as an oncogene in several human cancers. However, the clinical significance and biological role of PTOV1 remain elusive non-small cell lung cancer (NSCLC). The Cancer Genome Atlas (TCGA) data NCBI/GEO mining, western blotting analysis immunohistochemistry were employed to characterize expression NSCLC lines tissues. was studied by statistical Kaplan–Meier Plotter database mining. A series in-vivo in-vitro assays, including colony...
Accurately identifying and quantifying cellular autophagy is very important as the significance of in physiological pathological processes becomes increasingly evident. Ectopically expressed fluorescent‐tagged microtubule‐associated protein light chain 3B ( MAP1LC3B, LC3 ) most widely used reporter for monitoring activity thus far. However, this approach ignores influence constitutively overexpressed on itself autophagy‐related its accuracy indicating questionable. Here, we generated a...
Lung cancer is the most common and leading cause of cancer‐related death worldwide; hence, it imperative that mechanisms underlying malignant properties lung be uncovered in order to efficiently treat this disease. Increasing evidence has shown WT1‐interacting protein (WTIP) plays important roles both physiologically pathologically humans; however, role WTIP unknown. Here, we investigated mechanism cell proliferation tumorigenesis non‐small‐cell (NSCLC). We report a tumor suppressor human...
Human BST-2 inhibits HIV-1 replication by tethering nascent virions to the cell surface. codes Vpu that counteracts down-regulating this restriction factor from This important function makes a potential therapeutic target. Yet, no agents have been reported block antagonizing BST-2. In study, we report small molecule compound IMB-LA abrogates of and thereby strongly suppresses sensitizing virus restriction. Further studies revealed specifically Vpu-mediated degradation restores expression at...
While Highly Active Antiretroviral Therapy (HAART) has significantly decreased the mortality of human immunodeficiency virus (HIV)-infected patients, emerging drug resistance to approved HIV-1 integrase inhibitors highlights need develop new antivirals with novel mechanisms action. In this study, we screened a library microbial natural compounds from endophytic fungus Colletotrichum sp. and identified alternariol 5-O-methyl ether (AME) as compound that inhibits pre-integration steps. Time-of...
BST-2 is an interferon-induced host restriction factor that inhibits the release of diverse mammalian enveloped viruses from infected cells by physically trapping newly formed virions onto cell surface. Human Immunodeficiency Virus-1 (HIV-1) encodes accessory protein Vpu antagonizes down-regulating surface.Using a cell-based ELISA screening system, we have discovered lead compound, 2-thio-6-azauridine, restores surface level in presence Vpu. This compound has no effect on expression and Vpu,...
Formation of biomolecular condensates by phase separation has recently emerged as a new principle for regulating gene expression in response to extracellular signaling. However, the molecular mechanisms underlying coupling signal transduction and activation through condensate formation, how dysregulation these contributes disease progression, remain elusive. Here, authors report that CREB-regulated transcription coactivator 2 (CRTC2) translocates nucleus forms phase-separated upon cAMP They...
Abstract Metastasis is the major cause of cancer‐related death cancer patients. Epithelial‐mesenchymal transition (EMT) one critical process during cascade tumor metastasis. EMT a developmental program exploited by cells to from epithelial state mesenchymal and confers metastatic properties as well treatment resistance. Finding factors inhibit will greatly improve prognosis Spermatogenesis associated 2 (SPATA2) was originally isolated human testis proved playing role in spermatogenesis. To...
Bone marrow stromal cell antigen 2 (BST-2) inhibits the release of enveloped viruses from surface. Various viral counter measures have been discovered, which allow to escape BST-2 restriction. Human immunodeficiency virus type 1 (HIV-1) encodes protein U (Vpu) that interacts with through their transmembrane domains and causes downregulation surface BST-2. In this study, we used a computer modeling method establish molecular model investigate binding interface Vpu. The predicts is composed...
Bone marrow stromal cell antigen 2 (BST-2) inhibits the release of HIV-1 and other enveloped viruses from surface. Vpu binds to BST-2 through an interaction between transmembrane domains (TMD) two proteins induces downregulation surface BST-2, thereby counteracting its antiviral activity. In this study, we designed prepared a modified peptide BST2-TM-P1, which include sequence TMD, keeping property competing with bind Vpu. Biological assay results indicate BST2-TM-P1 could increase level at...
APOBEC3G(A3G) is a host cytidine deaminase that incorporates into HIV-1 virions and efficiently inhibits viral replication. The virally encoded protein Vif binds to A3G induces its degradation, thereby counteracting the antiviral activity of A3G. Vif-mediated degradation clearly represents potential target for anti-HIV drug development. Currently, there an urgent need understanding three dimensional structure full-length In this work, we use homology modeling approach propose based on...
Objective: Radiotherapy has achieved remarkable effects in treating non-small cell lung cancer (NSCLC). However, radioresistance remains the major obstacle to achieving good outcomes. This study aims at identifying potential targets for radiosensitizing NSCLC and elucidating underlying mechanisms. Methods: Lentivirus-based infection CRISPR/Cas9 technology were used modulate expression of microRNA-384 (miR-384). Cell clonogenic formation assays a xenograft tumor model analyze radiosensitivity...