A5101926979- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Oral microbiology and periodontitis research
- Ear Surgery and Otitis Media
- Gut microbiota and health
- Dental Health and Care Utilization
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Phonocardiography and Auscultation Techniques
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Cancer Risks and Factors
- Oral Health Pathology and Treatment
- Lung Cancer Treatments and Mutations
- Glaucoma and retinal disorders
- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- RNA modifications and cancer
- Cancer-related gene regulation
- Childhood Cancer Survivors' Quality of Life
- Speech and Audio Processing
- Hearing Loss and Rehabilitation
- Nasal Surgery and Airway Studies
- PI3K/AKT/mTOR signaling in cancer
Shanghai Ninth People's Hospital
2011-2025
Shanghai Jiao Tong University
2011-2025
National Clinical Research Center for Digestive Diseases
2020-2025
Chinese PLA General Hospital
2025
Xi’an Jiaotong-Liverpool University
2025
Xuzhou Medical College
2016-2024
Nanjing Medical University
2019-2024
Changhai Hospital
2024
Second Military Medical University
2024
Kunming University of Science and Technology
2024
Globally, dental caries is the most prevalent chronic oral disease and affects roughly half of all children. The aim this report was to use metagenomic analyses investigate relationship between microbiome in preschool A total 25 preschoolers, aged 3 5 years old with severe early childhood (ECC), 19 age-matched, caries-free children as controls were recruited. Saliva samples collected from participants subjected analyses, whereby microbial communities investigated. revealed substantial...
Emerging evidence suggests that the essence of life is ecological balance neural, endocrine, metabolic, microbial, and immune systems. Gut microbiota have been implicated as an important factor affecting thyroid homeostasis.This study aims to explore relationship between gut development carcinoma.Stool samples were collected from 90 carcinoma patients (TCs) healthy controls (HCs). Microbiota analyzed using 16S ribosomal RNA gene sequencing. A cross-sectional exploratory cohort 60 TCs HCs was...
Precancerous lesions of the oral mucosa, especially those accompanied by moderate to severe dysplasia, contribute initiation squamous cell carcinoma (OSCC). However, cellular compositions and spatial organization precancerous stage how these factors promote human OSCC remain unclear. Here, we built a single-cell transcriptome atlas map after obtaining data from pairwise mucosal biopsies 9 individuals consisting very early-stage OSCC, adjacent with as well matched normal region. An altered...
To compare the effects of five probiotic lactobacilli strains on growth and biofilm formation Streptococcus mutans (MS).Five bacteria (LB), Lactobacillus casei Shirota, LC01, plantarum ST-III, paracasei Lpc-37, rhamnosus HN001, were used as test effecting Streptococci strain S. UA159 in this study. The effect LB their supernatants viability MS was evaluated. Then, observed by fluorescence microscope.All inhibited at concentrations 1 × 10(8) 3 CFU ml(-1) (P < 0.05). Untreated (without pH...
BACKGROUND:An accurate and valid caries prevention policy is absent in Zhejiang because of insufficient data. Therefore, the aim this study was to investigate oral health status related risk factors 12- 14-year-old students Zhejiang, China. MATERIAL AND METHODS:Using multi-stage, stratified, random sampling, we recruited a total 4860 aged 12 14 years old from 6 regions cross-sectional study. Dental measured using Decayed, Missing Filled Teeth (DMFT) index Significant Caries Index (SiC)....
Background: Alterations of oral microbiota are the main cause progression caries. The goal this study was to characterize in childhood caries based on single-molecule real-time sequencing. Methods: A total 21 preschoolers, aged 3-5 years old with severe early caries, and 20 age-matched, caries-free children as controls were recruited. Saliva samples collected, followed by DNA extraction, Pacbio sequencing phylogenetic analyses microbial communities. Results: 876 species derived from 13 known...
Dynamic alterations in oral microbiota are closely related to the development of dental caries;however, changes salivary during this process have not been extensively studied. In addition, increasing evidence suggests that microbiome profiles differ according dentition stages, but it is unclear whether they change with age same , such as deciduous dentition. These two aspects were investigated a 2-year follow-up study, and caries-free preschool children complete enrolled. Saliva was...
A disintegrin and metalloprotease 12 (ADAM12), an essential transmembrane protein with metalloprotease, cell binding intracellular signal‑regulating capabilities, has been reported to play a crucial role in various types of cancers. However, the biological function ADAM12 gastric cancer (GC) remains unclear. Bioinformatic experimental analyses were used determine expression level prognostic value GC. The DNA methylation competing endogenous RNA (ceRNA) network was identified using MethSurv,...
Dental caries in preschool children is prevalent worldwide, but data regarding its magnitude and associated factors were not available for Zhejiang Province, China. This study examines the dental situation Province. A total of 1591 aged 3–5 years their parents or caregivers enrolled this study. The condition teeth was assessed by three technicians qualified to WHO 2013 criteria. structured questionnaire completed children's caregivers. logistic regression analysis used analyze risk that may...
Apatinib, a vascular endothelial growth factor receptor (VEGFR) blocker, has demonstrated encouraging antitumor activities and tolerable toxicities in various cancer types. Recurrent or metastatic adenoid cystic carcinoma of the head neck (R/MACCHN) carries poor prognosis, treatment options are currently limited. This study was conducted to explore activity safety apatinib patients with R/MACCHN.In this phase II single-arm, prospective study, aged 15-75 years incurable R/MACCHN received at...
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant cancers. The treatment HNSCC remains challenging despite recent progress in targeted therapies immunotherapy. Research on predictive biomarkers clinical settings urgently needed.Next-generation sequencing analysis was performed tumor samples from 121 patients with recurrent or metastatic underwent analysis. Clinicopathological information collected, outcomes were assessed. Progression-free survival (PFS)...
<title>Abstract</title> <bold>Background：</bold>Malignant neoplasm is one of the leading durden diseases worldwide, particularly among women child-bearing age (WCBA) with a significant higher incidence rate than their male counterparts. This study aimed to assess burden and trend cancers WCBA from 1990 2021. <bold>Methods: </bold>This retrieved data Global Burden Disease Study (GBD) 2021 on incidence, prevalence, disability adjusted life-years (DALYs) 30 Estimated annual percentage changes...
<title>Abstract</title> The Grcar matrix is a class of non-symmetric Toeplitz upper Hessenberg matrices with banded structure. In recent paper [G. Meurant, A note on the Matrix, Numerical Algorithms, https://doi.org/10.1007/s11075-024-01999-2], recursive formula for its determinant, LU factorization and asymptotic spectrum have been studied. Inspired by results, this extends analysis to characteristic polynomials inverse representations. Furthermore, we conduct comprehensive numerical...
Abstract Wideband Absorbance Immittance (WAI) has been available for more than a decade, however its clinical use still faces the challenges of limited understanding and poor interpretation WAI results. This study aimed to develop Machine Learning (ML) tools identify absorbance characteristics across different frequency-pressure regions in normal middle ear ears with otitis media effusion (OME) enable diagnosis conditions automatically. Data analysis included pre-processing data, statistical...
Novel systemic agents and effective treatment strategies for recurrence adenoid cystic carcinoma (ACC) of the head neck are still worthy further exploration. Here, we analyzed mutations expression profiles 75 Chinese ACC patients, characterized prognostic value immune signature or distant metastasis, explored potential immunotherapeutic biomarkers in ACC. In general, MYB fusion somatic accounted a high proportion, which was 46.7% (35/75). ACCs displayed an overall low mutation burden lack...
Background and objectives Patients with locally advanced head neck squamous cell carcinoma (HNSCC) typically undergo surgery followed by postoperative radiotherapy/chemoradiotherpy. Nutritional issues often arise during treatment, potentially affecting outcomes. This study aimed to investigate whether early initiation of oral nutritional supplements (ONS) would prevent weight loss in HNSCC patients undergoing radiotherapy/chemoradiotherapy compared conventional intervention.