A5060450259- Osteoarthritis Treatment and Mechanisms
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Congenital Heart Disease Studies
- Bone Tissue Engineering Materials
- Pulmonary Hypertension Research and Treatments
- Organometallic Complex Synthesis and Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Cardiovascular and Diving-Related Complications
- Cardiovascular Conditions and Treatments
- Extracellular vesicles in disease
- Meningioma and schwannoma management
- Cardiac Arrhythmias and Treatments
- Tissue Engineering and Regenerative Medicine
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Proteoglycans and glycosaminoglycans research
- Metal complexes synthesis and properties
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Vascular Malformations Diagnosis and Treatment
- Asymmetric Hydrogenation and Catalysis
Sichuan University
2012-2025
General Hospital of Shenyang Military Region
2014-2025
Collaborative Innovation Center of Advanced Microstructures
2024-2025
Nanjing University
2023-2025
West China Hospital of Sichuan University
2017-2024
Hong Kong Baptist University
2021-2024
Zhejiang A & F University
2023-2024
Hubei University of Medicine
2023
Taihe Hospital
2023
Northeast Forestry University
2023
Cellular senescence serves as a fundamental and underlying activity that drives the aging process, it is intricately associated with numerous age-related diseases, including Alzheimer's disease (AD), neurodegenerative aging-related disorder characterized by progressive cognitive impairment. Although increasing evidence suggests senescent microglia play role in pathogenesis of AD, their exact remains unclear. In this study, we quantified levels lactic acid microglia, hippocampus tissues...
As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent characteristics, targeting could be a potential therapeutic strategy. In this study, exosomes derived umbilical cord-derived mesenchymal stem cells (UCMSC-EXOs) combined with the chondrocyte-targeting capacity controlled-release system were proposed for osteoarthritis (OA) treatment via rejuvenating chondrocytes. The essential functional miRNAs within UCMSC-EXOs investigated, p53 signaling pathway identified as...
Abstract Abnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint dysplasia and osteoarthritis (OA); However, the clinical translation FGF18‐based protein drugs is hindered by their short half‐life, low delivery efficiency need for repeated articular injections. This study proposes a CRISPR/Cas9‐based approach effectively activate FGF18 gene OA chondrocytes at genome level in vivo, using chondrocyte‐affinity peptide (CAP) incorporated hybrid exosomes...
Abstract Hydrocephalus is one of the most common brain disorders and a life‐long incurable condition. An empirical “one‐size‐fits‐all” approach cerebrospinal fluid (CSF) shunting remains mainstay hydrocephalus treatment effective pharmacotherapy options are currently lacking. Macrophage‐mediated ChP inflammation CSF hypersecretion have recently been identified as significant discovery in pathogenesis hydrocephalus. In this study, pioneering DNA nano‐drug (TSOs) developed by modifying S2...
Abstract As emerging therapeutic factors, extracellular vesicles (EVs) offer significant potential for myocardial infarction (MI) treatment. Current delivery approaches EVs involve either intra‐myocardial or intravenous injection, where both have inherent limitations downstream clinical applications such as secondary tissue injury and low efficiency. Herein, an injection‐free approach delivering onto the heart surface to treat MI is proposed. By spraying a mixture of EVs, gelatin...
Injury to articular cartilage cause certain degree of disability due poor self-repair ability tissue. To promote regeneration, it is essential develop a scaffold that properly mimics the native extracellular matrix (ECM) in aspect compositions and functions.A mussel-inspired strategy was developed construct an ECM-mimicking hydrogel by incorporating polydopamine-modified hyaluronic acid (PDA/HA) complex into dual-crosslinked collagen (Col) for growth factor-free regeneration. The adhesion,...
Abstract We study how the social transmission of public news influences investors’ beliefs and securities markets. Using data on networks, we find that earnings announcements from firms in higher-centrality counties generate a stronger immediate price, volatility, trading volume reactions. Post-announcement, such experience weaker price drift faster volatility decay but higher more persistent volume. These findings suggest greater connectedness facilitates timely incorporation into prices,...
Inadequate vascularization significantly hampers wound recovery by limiting nutrient delivery. To address this challenge, we extracted membrane vesicles from Lactobacillus reuteri (LMVs) and identified their angiogenic potential via transcriptomic analysis. We further developed a composite hydrogel system (Gel-LMVs) anchoring LMVs within carboxylated chitosan cross-linking it with oxidized hyaluronic acid through Schiff base reaction. The resulting Gel-LMVs exhibit good biocompatibility...
Osteoarthritis (OA) presents a significant therapeutic challenge, with few options for preserving joint cartilage and repairing associated tissue damage. Inflammation is pivotal factor in OA-induced deterioration synovial inflammation. Recently, exosomes derived from human umbilical cord mesenchymal stem cells (HucMSCs) have gained recognition as promising noncellular modality, but their use hindered by the challenge of harvesting sufficient number effective efficacy. Given that HucMSCs are...
Abstract Osteoporosis, characterized by low bone mass and high fracture risk, challenges orthopedic implant design. Conventional 3D‐printed Ti6Al4V scaffolds are mechanically robust but suffer from poor regeneration in osteoporotic patients due to stress shielding cellular senescence. In this study, a functionalized “Cell Climbing Frame” is developed, aiming adapt the mechanical microenvironment of osteoporosis, effectively recruit support adhesion growth autologous marrow mesenchymal stem...
The P2X7 receptor (P2X7R) is attracting increasing attention for its involvement in cancer. Several recent studies have shown a crucial role of P2X7R tumour cell growth, angiogenesis and invasiveness. In this study, we investigated the two known human functional splice variants, full length P2X7RA truncated P2X7RB, osteosarcoma growth. Immunohistochemical analysis tissue array osteosarcomas showed that forty-four, total fifty-four tumours (81.4%), stained positive both B, thirty-one (57.4%)...
Articular cartilage has very poor intrinsic healing ability and its repair remains a significant clinical challenge. To promote neocartilage regeneration, we fabricated two collagen (Col) scaffolds functionalized with porcine decellularized extracellular matrix (dECM) in the forms of particle solution named pE-Col sE-Col, respectively. Their differences were systematically compared, including biochemical compositions, scaffold properties, cell–material interactions, situ regeneration. While...
World Health Organization (WHO) group 1 pulmonary arterial hypertension (PAH) is a progressive, debilitating disease. Previous observational studies have demonstrated that artery denervation (PADN) reduces pressures in PAH. However, the safety and effectiveness of PADN not been established randomized trial. The aim this study was to determine treatment effects patients with Patients WHO PAH taking PAH-specific drugs for at least 30 days were enrolled multicenter, sham-controlled,...
The reaction of Ag2 C2 with a concentrated aqueous solution AgF leads to the title compound, in which dianion C22- is completely enclosed Ag9 cage chandelierlike arrangement ten silver atoms.