A5102005261- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanocluster Synthesis and Applications
- Biosensors and Analytical Detection
- Luminescence and Fluorescent Materials
- Electrochemical sensors and biosensors
- Nanoplatforms for cancer theranostics
- Advanced Fluorescence Microscopy Techniques
- Quantum Dots Synthesis And Properties
- Lipid Membrane Structure and Behavior
- Mycotoxins in Agriculture and Food
- Advanced Photocatalysis Techniques
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Near-Field Optical Microscopy
- Nanoparticle-Based Drug Delivery
- Listeria monocytogenes in Food Safety
- Neonatal and Maternal Infections
- Indoor Air Quality and Microbial Exposure
- Alzheimer's disease research and treatments
- Advanced Biosensing Techniques and Applications
- Mercury impact and mitigation studies
- Supramolecular Self-Assembly in Materials
Hunan Normal University
2016-2025
Hubei University
2024-2025
Fujian Normal University
2025
Shandong University of Technology
2021-2023
Nanjing University of Chinese Medicine
2023
The Fourth People's Hospital of Zibo City
2021-2023
Hunan Provincial People's Hospital
2023
Jiangxi Science and Technology Normal University
2021
Changsha University
2020
State Key Laboratory of Chemobiosensing and Chemometrics
2011
Cellular senescence serves as a fundamental and underlying activity that drives the aging process, it is intricately associated with numerous age-related diseases, including Alzheimer's disease (AD), neurodegenerative aging-related disorder characterized by progressive cognitive impairment. Although increasing evidence suggests senescent microglia play role in pathogenesis of AD, their exact remains unclear. In this study, we quantified levels lactic acid microglia, hippocampus tissues...
Photodynamic therapy (PDT) has attracted great attention as an alternative tumor treatment method. Unfortunately, it suffers from some limitations like poor targeting capability and insufficient therapeutic efficiency caused by hypoxia. In this work, we introduce a novel O2-evolving PDT nanoparticle for homologous cancer cell well dual-mode imaging [i.e., magnetic resonance (MRI) fluorescence imaging]. Specifically, the nanostructure consists of MnO2 nanosheet-coated metal–organic framework...
The cellular uptake efficiency of nanostructures has been demonstrated to be highly dependent on the surface charge, size and shape although internalization process is still far from being well-understood.
Dynamic changes of mitochondrial morphology play an important role in cellular metabolism. Real-time monitoring ultrastructural dynamics at nanometer-scale resolution is crucially desired for further understanding the mitochondria-based function. In this work, we introduce a fluorescent carbon dot, which can selectively target mitochondria live cells (named as MitoCD). MitoCD effectively accumulate regardless decrease or vanishing membrane potential (MMP), enabling exploration...
Bimetallic nanostructures are a promising candidate for plasmon-driven photocatalysis. However, knowledge on the generation and utilization of hot carriers in bimetallic is still limited. In this work, we explored Pt position-dependent photocatalytic properties Au nanobipyramids (Au NBPs) with single-molecule fluorescence imaging. Compared all-deposited core–shell (aPt-Au NBPs), imaging simulation results show that end-deposited (ePt-Au can maintain strong electromagnetic (EM) field further...
Abstract In this work, we demonstrated a convenient and green strategy for the synthesis of highly luminescent water-soluble carbon dots (Cdots) by carbonizing precursors, i.e., Bovine serum albumin (BSA) nanoparticles, in water solution. Without post surface modification, as-synthesized Cdots exhibit fluorescence quantum yield (Q.Y.) as high 34.8% display superior colloidal stability not only concentrated salt solutions (e.g. 2 M KCl) but also wide range pH solutions. According to FT-IR...
In this work, we developed a simple yet robust single particle scattering intensity measurement method for the quantification of cancer-related biomarkers. The design is based on plasmonic coupling effect between noble metal nanoparticles. First, primary and secondary antibodies were conjugated onto surface 60 nm gold nanoparticles (AuNPs, act as capture probes) 50 silver (AgNPs, signal amplification respectively. presence corresponding antigen, sandwiched immunocomplex was formed, resulting...
Within living cells, the biological functions of subcellular organelles are highly dependent on distribution local temperature. In this regard, sensitive and accurate measurement cellular temperature with resolution is fundamentally practically significant. work, we demonstrated a fluorescence-based self-calibration method for quantitative analysis cell A ratiometric sensor was designed by conjugating dye, Rhodamine B (RhB), biocompatible carbon dots (CDs) via covalent bond. The as-prepared...
We propose a novel SERS platform for the detection of enzyme activity by modulating distance between Raman reporters and surface Au NBPs with MnO<sub>2</sub> shell as spacer.
A fluorometric and colorimetric dual mode sensing platform based on hybridized carbon dots (Cdots) gold-silver core-shell nanoparticles (Au@Ag NPs) has been established for the sensitive detection of trace Cu2+ ions in aqueous solution. In this system, fluorescence Cdots was quenched by Au@Ag NPs due to surface plasmon-enhanced energy transfer. Due fact that could accelerate etching process presence thiosulfate, recovered. The limit (LOD) is 4.81 nM measurements 3.85 measurements. dynamic...
Herein, we demonstrated a new optical microscopy method to selectively image small-size gold nanoparticles (GNPs) inside noisy living cells through determination of the difference between probe beam (illuminated at resonance wavelength GNPs, 532 nm) and reference 473 nm). From computer simulation single-particle imaging experiments, that GNPs with diameter 45 nm could be imaged in GNPs/cell lysates mixture by dual-wavelength (DWD) imaging. The diffusion dynamics nucleic acids functionalized...
Acetylcholinesterase (AChE) plays a vital role in nerve conduction through rapidly hydrolyzing the neurotransmitter acetylcholine (ACh) and is correlated with Alzheimer's disease. In this work, label-free single-particle enumeration (SPE) method for quantitative detection of acetylcholinesterase activity developed. The design based on fluorescence resonance energy transfer (FRET) between fluorescent conjugated polymer nanoparticles (FCPNPs) MnO2 nanosheets. FCPNPs can be effectively quenched...
Fibrillar species have been proposed to play an essential role in the cytotoxicity of amyloid peptide and pathogenesis neurodegenerative diseases. Discrimination Aβ aggregates situ at high spatial resolution is therefore significant for development a therapeutic method. In this work, we adopt rhodamine-like structure as luminescent centers fabricate carbonized fluorescent nanoparticles (i.e., carbon dots, RhoCDs) with tunable emission wavelengths from green red burst-like photoblinking...
Development of intelligent and multifunctional nanoparticle for the diagnosis treatment cancer has drawn great attention recently. In this work, we design a smart two-dimensional (2D) supraparticle tumor targeted magnetic resonance imaging (MRI)/photothermal (PTI) chemo/photothermal therapy (PTT).
2,5-Diketopiperazines (2,5-DKPs) are recognized for their structural rigidity and diverse bioactivities, making them significant in drug discovery. However, the stereochemical complexity of 2,5-DKPs presents challenges chemical synthesis, particularly concerning indole derivatives such as diketopiperazines (IDKPs). Prenylation oxidation further diversify these structures, enhancing bioactivity membrane affinity. Despite recent advances, biosynthetic pathways IDKPs, especially those involving...
Exploring the diffusion dynamics of a viral capsid proteins (VCP)-functionalized nanocarrier on living cell membrane could provide much kinetic information for better understanding their biological functionality. Gold nanoparticles are an excellent core material nanocarriers because good biocompatibility as well versatile surface chemistry. However, due to strong scattering background from subcellular organelles, it is grand challenge selectively image individual membrane. In this work, we...
In this work, the distinct catalytic properties of a single gold nanoparticle (GNP) after symmetry breaking were disclosed at single-particle level for first time.
Open AccessCCS ChemistryRESEARCH ARTICLE1 Mar 2022Fast Surface Restructuring within the Gap of Au Nanocube Dimer for Enhancement Catalytic Efficiency Xiao Wang, Zhongju Ye, Jianhao Hua, Lin Wei, Shen and Lehui Wang State Key Laboratory Medicinal Chemical Biology, Tianjin Biosensing Molecular Recognition, College Chemistry, Nankai University, 300071 , Ye Hua Wei Chemistry Engineering, Hunan Normal Changsha 410081 *Corresponding author: E-mail Address: [email protected]...
Self-propelled nanomotors have shown enormous potential in biomedical applications. Herein, we report on a nanozyme-powered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under near-infrared (NIR) laser irradiation. The is constructed by the asymmetric decoration of platinum nanoparticles (PtNPs) at bottom gold nanocups (GNCs). PtNPs with robust peroxidase- (POD-) like activity are employed not only as propelling elements but also continuous O...