A5100718414- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Modular Robots and Swarm Intelligence
- Bone Metabolism and Diseases
- Advanced Materials and Mechanics
- Dental materials and restorations
- Plant responses to water stress
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Periodontal Regeneration and Treatments
- Traditional Chinese Medicine Studies
- Biomedical Text Mining and Ontologies
- Silk-based biomaterials and applications
- Traditional Chinese Medicine Analysis
- Medical and Biological Sciences
- Micro and Nano Robotics
- 3D Printing in Biomedical Research
- Dental Erosion and Treatment
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Plant responses to elevated CO2
- Graphene and Nanomaterials Applications
- Spinal Fractures and Fixation Techniques
University of Science and Technology of China
2024-2025
Soochow University
2024-2025
Second Affiliated Hospital of Soochow University
2024-2025
Chongqing University
2025
Anhui Medical University
2025
Sichuan Academy of Traditional Chinese Medicine
2006-2024
Shandong University of Traditional Chinese Medicine
2023-2024
Beijing Geriatric Hospital
2023
Capital Medical University
2023
Weifang People's Hospital
2023
Abstract Aims Assessing the global burden and health inequalities of Hypertension Heart Disease (HHD) during period from 1990 to 2019. Methods Secondary analysis Global Burden (GBD) study in 2019, focusing on diseases, injuries, risk factors worldwide. Disability-Adjusted Life Years (DALYs) data related HHD are extracted 2019 GBD. Inequality Slope Index (SII) Concentration calculated assess across regions countries. Results The total DALYs for reached 21.51 million, demonstrating a...
A double-crosslinked hydrogel with injectability, self-healing capability, stability, and antibiosis was developed. Silver ions were in situ bioreduced to AgNPs rapidly uniformly at the same time as formation of hydrogels.
Abstract The relationships of Klotho levels with cognition and dementia are poorly understood. This study aimed to investigate the association between cognitive function determine causality using Mendelian randomization (MR). Based on data from National Health Nutrition Survey (NHANES) 2011–2014, this consisted 1875 older adults aged 60–79 years. Cognitive was assessed by digit symbol substitution test (DSST). We performed weighted multivariable-adjusted linear regression assess...
Rotator cuff tears are the most common conditions in sports medicine and attract increasing attention. Scar tissue healing at tendon-bone interface results a high rate of retears, making it major challenge to enhance rotator interface. Biomaterials currently employed for still exhibit limited efficacy. As promising technology, 3D printing enables customization scaffold shapes properties. Bone marrow mesenchymal stem cells (BMSCs) have multidifferentiation potential valuable immunomodulatory...
We have developed an injectable thiolated icariin functionalized hyaluronic acid/collagen hydrogel under physiological conditions to facilitate cell proliferation, maintain chondrocyte phenotype and promote the secretion of cartilage extracellular matrix.
The different negatively charged microenvironments of collagen hydrogels affect the protein adsorption, cell morphology, and chondrogenic differentiation BMSCs<italic>in vitro</italic>and<italic>in vivo</italic>.
To effectively treat articular cartilage defect with tissue engineering there is an urgent need to develop safe and cheap drugs that can substitute or cooperate growth factors for chondrogenesis promotion. Here, we demonstrate the chondrogenic effect of icariin, major pharmacological active constituent Herb Epimedium (HEP). Rabbit chondrocytes were isolated from cultured in vitro different concentrations icariin. Icariin at under 1 × 10⁻⁵ M showed low cytotoxicity toward chondrocytes, but...
Adverse drug-drug interaction (ADDI) becomes a significant threat to public health. Despite the detection of ADDIs is experimentally implemented in early development phase drug design, many potential are still clinically explored by accidents, leading large number morbidity and mortality. Several computational models designed for ADDI prediction. However, they take no consideration dependency, although drugs usually produce synergistic effects own highly mutual dependency treatments, which...
Magnetic soft grippers have attracted intensive interest due to their untethered controllability, rapid response, and biological safety. However, manipulating living objects requires a simultaneous increase in shape adaptability gripping force, which are typically mutually exclusive. Increasing the magnetic particle content enhances strength but also increases elastic modulus, leading low high impact force. Here, porous gripper (PMSG) is developed by integrating structure into silicone...
Inspired by the nanostructure of bone, biomimetic nanocomposites comprising natural polymers and inorganic nanoparticles have gained much attention for bone regenerative applications. However, mechanical biological performances are largely limited inhomogeneous distribution, uncontrolled size irregular morphology at present. In this work, an innovative in situ precipitation method has been developed to construct a nanocomposite which consists spherical hydroxyapatite (HA) gelatin (Gel). The...
Soft machines actuated by external magnetic fields have gained significant attention for their potential to interact with living organisms and complex environments. However, adaptability functionality are often limited rigid magnetization during operation. In this work, we introduce dynamically reprogrammable soft in situ reconfigurable profiles operations, achieved through the synergy of various fields. A flexible resonant circuit is integrated into machine body, enabling addressable...
Abstract Background Overexpressed vascular endothelial growth factor A (VEGFA) and phosphorylated signal transducer activator of transcription 3 (P-STAT3) cause unrestricted tumor angiogenesis breast cancer (BRCA), especially triple-negative (TNBC). Hence, novel treatment strategy is urgently needed. Results We found sphingosine 1 phosphate receptor (S1PR1) can regulate P-STAT3/VEGFA. Database showed S1PR1 highly expressed in BRCA causes the poor prognosis patients. Interrupting expression...
The regeneration of bone defects in osteoporotic patients presents a big challenge. Icariin (Ica), which is the main active component traditional Chinese medicine - herba epimedii, has been widely loaded to scaffolds for treatment fracture and osteoporosis. To increase drug loading capacity, meanwhile achieve stable safe delivery, present study, novel icariin derivative thiolated (Ica-SH) molecule with good cytocompatibility bioactivity was incorporated into biphasic calcium phosphate (BCP)...
The dynamic balance between bone resorption and formation is critical for maintaining healthy homeostasis. However, the receptor activator of nuclear factor B ligand (RANKL) primarily stimulates mature osteoclasts to resorb bone, its upregulation leads osteoporosis in patients. Here, we designed RANK-expressing extracellular vesicles (EVs) derived from mesenchymal stem cells maintain homeostasis mice. This engineered EV (EV@R) effectively neutralizes excess RANKL tissue due RANK-RANKL...