A5100704468- Biofuel production and bioconversion
- Algal biology and biofuel production
- Microbial Metabolism and Applications
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Microbial Metabolic Engineering and Bioproduction
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Advanced Proteomics Techniques and Applications
- Polysaccharides and Plant Cell Walls
- Plant Gene Expression Analysis
- Cell death mechanisms and regulation
- Antimicrobial agents and applications
- Enzyme Catalysis and Immobilization
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Plant biochemistry and biosynthesis
- Immunotherapy and Immune Responses
- Photosynthetic Processes and Mechanisms
- Antioxidant Activity and Oxidative Stress
- Acute Lymphoblastic Leukemia research
- Biochemical Analysis and Sensing Techniques
- Nanocomposite Films for Food Packaging
- Silk-based biomaterials and applications
Beijing University of Chemical Technology
2006-2025
Huaian First People’s Hospital
2015
Peking University
2008
Accumulated evidence demonstrated that long non-coding RNAs (lncRNAs) play a pivotal role in tumorigenesis. However, it is still largely unknown how these lncRNAs were regulated by small ncRNAs, such as microRNAs (miRNAs), at the post-transcriptional level. We here use lncRNA HOTTIP an example to study miRNAs impact expression and its biological significance hepatocellular carcinoma (HCC). LncRNA vital oncogene HCC, one of deadliest cancers worldwide. In current study, we identified miR-192...
Surface-engineered particulate delivery systems for vaccine administration have been widely investigated in experimental and clinical studies. However, little is known about charge-coated microspheres as potential recombinant subunit protein antigen terms of adsorption related immune responses. In the present study, cationic polymers, including chitosan (CS), chloride (CSC), polyethylenimine (PEI), were used to coat PLA build positively charged surfaces. Antigen capacity was enhanced with...
Enhanced production stability and efficiency along with a decrease in costs are required to build efficient microbial cell factories. Target genes can be integrated into the genome enhance genetic stability, reduce reliance on antibiotics, alleviate metabolic burden. However, selecting optimal insertion site for desired gene expression levels remains challenging. Therefore, 18 commonly used
Abstract Gallic acid (GA) and β‐glucogallin (BGG) are natural products with diverse uses in pharmaceutical, food, chemical cosmetic industries. They valued for their wide‐ranging properties such as antioxidant, antibacterial, antidiabetic, anticancer properties. Despite significant importance, microbial production of GA BGG faces challenges limited titers yields, along the incomplete understanding biosynthesis pathways microorganisms. To address these challenges, we developed a recombinant...
Borneol-grafted cellulose (BGC) exhibited a remarkable performance in antifungal adhesion and fungal growth inhibition based on biological surface recognition.
Benzyl alcohol (BALC) is a naturally occurring compound widely used in the fragrance, pharmaceutical, and chemical industries. Traditional synthesis involves toxic materials costly purification, resulting products are often labeled as "artificial fragrances", which generally less favored by consumers due to concerns about their safety, sustainability, environmental impact. Biosynthesis offers sustainable alternative for "naturally derived" BALC, but existing pathways face insufficient...